Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
two-component response regulator
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| D20N | - | overexpression of adeB, enhanced efflux activity, efflux system response regulator transcription factor AdeR | Acinetobacter baumannii | TigecyclineLevofloxacin|Tigecycline|Trimethoprim-sulfamethoxazoleEFFLUX | Reference Gene CatalogReslit | Confirmed |
| A80P | - | Acinetobacter baumannii | Tigecycline | Reslit | Candidate |
| E219A | - | efflux system response regulator transcription factor AdeR | Acinetobacter baumannii | EFFLUX | Reference Gene Catalog | Established |
| P56S | - | efflux system response regulator transcription factor AdeR | Acinetobacter baumannii | EFFLUX | Reference Gene Catalog | Established |
| L192R | - | efflux system response regulator transcription factor AdeR, alter protein stability | Acinetobacter baumannii | EFFLUXCiprofloxacin | Reference Gene CatalogReslit | Confirmed |
| I228V | - | - | Acinetobacter baumannii | Fluoroquinolones | Reslit | Candidate |
| I120V | - | - | Acinetobacter baumannii | Tigecycline | Reslit | Candidate |
| F132S | - | - | Acinetobacter baumannii | Fluoroquinolones | Reslit | Candidate |
| I175L | - | - | Acinetobacter baumannii | Fluoroquinolones | Reslit | Candidate |
| L227I | - | - | Acinetobacter baumannii | Fluoroquinolones | Reslit | Candidate |
| D21V | - | - | Acinetobacter baumannii | Tigecycline|Fluoroquinolones|Aminoglycoside|Macrolide|Carbapenem|Tetracycline | Reslit | Candidate |
| L142I | - | - | Acinetobacter baumannii | MeropenemCarbapenem | Reslit | Candidate |
| A136V | - | alter interactions between AdeS and AdeR | Acinetobacter baumannii | Tigecycline|Levofloxacin|CiprofloxacinCiprofloxacin | Reslit | Candidate |
| A91V | - | alter interactions between AdeS and AdeR, efflux system response regulator transcription factor AdeR | Acinetobacter baumannii | CiprofloxacinEFFLUX | Reference Gene CatalogReslit | Confirmed |
| R123H | - | - | - | Aminoglycoside|Tetracycline|Chloramphenicol|Tigecycline | Reslit | Candidate |
| V243I | - | - | - | Carbapenem | Reslit | Candidate |
| P116L | efflux system response regulator transcription factor AdeR | Acinetobacter baumannii | EFFLUXCiprofloxacin | Reference Gene CatalogReslit | Confirmed |
| G186V | - | Acinetobacter baumannii | Tigecycline | Reslit | Candidate |
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| adeR | Card DatabaseReslit | 13 | Tetracycline, Levofloxacin +11 | Acinetobacter baumannii +5 | Iran, Chongqing|China, Italy|Arizona, United States, China, Guangzhou, China, China|Xinjiang | 2013, 2014, 2016, 2017, 2019, 2020, 2021, 2023, 2025 | AYOH01000000|PRJNA262565 | ADM92605.1 |
| ade R | Reslit | 1 | Glycylcyclines, Tetracycline | Acinetobacter baumannii | South Africa | 2022 | PRJNA765178 | - |
RND-Type Efflux Pumps in Multidrug-Resistant Clinical Isolates of Acinetobacter baumannii: Major Role for AdeABC Overexpression and AdeRS Mutations.
The study identifies mutations in the AdeRS two-component system that lead to overexpression of the AdeABC efflux pump, contributing to multidrug resistance in Acinetobacter baumannii.
Detection of AdeABC efflux pump genes in tetracycline-resistant Acinetobacter baumannii isolates from burn and ventilator-associated pneumonia patients.
The study found that all tetracycline-resistant Acinetobacter baumannii isolates possessed the AdeABC efflux pump genes, and the efflux pump contributed to tetracycline resistance as evidenced by reduced MICs upon CCCP treatment.
The Asp20-to-Asn Substitution in the Response Regulator AdeR Leads to Enhanced Efflux Activity of AdeB in Acinetobacter baumannii.
The Asp20→Asn substitution in the response regulator AdeR enhances efflux activity of AdeB, leading to reduced susceptibility to levofloxacin, tigecycline, and trimethoprim-sulfamethoxazole in Acinetobacter baumannii.
Transcriptome Remodeling of Acinetobacter baumannii during Infection and Treatment.
The study identifies mutations in pmrB, adeR, and adeS that affect gene expression and confer resistance to colistin and tigecycline in Acinetobacter baumannii.
Comparative genomic analysis and multi-drug resistance differences of Acinetobacter baumannii in Chongqing, China.
The study identified 19 drug resistance genes in 10 multidrug-resistant Acinetobacter baumannii strains, with efflux pump genes being the most prevalent. Key genes included aacA4, which had a 19-bp deletion associated with aminoglycoside resistance, and other genes like TEM-1, OXA-23, and ANT(3'')-IIa.
Can Insertion Sequences Proliferation Influence Genomic Plasticity? Comparative Analysis of Acinetobacter baumannii Sequence Type 78, a Persistent Clone in Italian Hospitals.
The study identified several carbapenem-resistant genes, including blaOXA-58, blaOXA-23, and blaOXA-90, along with insertion sequences ISAb1, ISAb25, and IS66, which contribute to genomic plasticity and resistance mechanisms in the SMAL clone of Acinetobacter baumannii.
Complete genome analysis of a virulent Vibrio scophthalmi strain VSc190401 isolated from diseased marine fish half-smooth tongue sole, Cynoglossus semilaevis.
The study identified several AMR genes in Vibrio scophthalmi strain VSc190401, including those conferring resistance to aminoglycosides, fluoroquinolones, tetracyclines, and polymyxins. Some of these genes were validated experimentally.
Acinetobacter baumannii Antibiotic Resistance Mechanisms.
The paper reviews various beta-lactamases and other resistance mechanisms in Acinetobacter baumannii, focusing on their roles in resistance to beta-lactams, aminoglycosides, and other antibiotics.
Molecular characterisation of Acinetobacter baumannii isolates from bloodstream infections in a tertiary-level hospital in South Africa.
The study identified colistin-resistant Acinetobacter baumannii isolates with resistance genes including bla OXA-23, bla NDM-1, lps B, and various efflux pumps. These isolates exhibited extensive drug resistance (XDR) and were associated with sequence types ST1 and ST2.
Identification and Characterization of a Vancomycin Intermediate-Resistant Staphylococcus haemolyticus Isolated from Guangzhou, China.
The study identifies vancomycin intermediate-resistant Staphylococcus haemolyticus SH-1 carrying multiple drug resistance genes and novel mutations in WalK gene associated with vancomycin resistance.
Complete genome sequencing and comparative genomic analysis of three donkey Streptococcus equi subsp. equi isolates.
The study identified multiple antibiotic resistance genes in three donkey-derived Streptococcus equi subsp. equi isolates, including genes conferring resistance to beta-lactams, tetracyclines, macrolides, fluoroquinolones, and others. Notably, the HT1112 isolate showed resistance to six antimicrobials, while HTP133 and HTP232 showed resistance to fewer drugs. Additionally, the study highlighted the role of biofilm formation in antimicrobial resistance.
Reciprocal regulation between Acinetobacter baumannii and Enterobacter cloacae AdeR homologs: implications for antimicrobial resistance and pathogenesis.
The study identifies and characterizes the roles of AdeB and AdeR homologs in Acinetobacter baumannii and Enterobacter cloacae, demonstrating their involvement in antimicrobial resistance, motility, and virulence. The AdeR regulators from both species are functionally interchangeable, highlighting conserved regulatory mechanisms.
Virulence and resistance gene analysis of Rothia nasimurium by whole gene sequencing.
The study identified multiple AMR genes in Rothia nasimurium Y1, including vanA, vanC, vanB, vanE, vanD, vanG, vanF, vanM, vanL, vanO, vanN, mtrA, vanRA, arlR, vanRI, vanRB, vanRC, vanRD, vanRF, vanRG, CpxR, kdpE, vanRM, vanRN, baeR, adeR, vanRL, smeR, gyrA, gyrB, parC, Mfd, mfd, PBP2, PBP2x, EF-Tu, dfrE, pncA, tetB(P), tetQ, tet44, tetT, tetW, tetS, tetM, tetO, otr(A), tet36, tet32, clbC, clbB, clbA, cipA, cfrA, cfrC, sul3, ParY, murA, cls, and ileS, which confer resistance to various antibiotics such as glycopeptides, beta-lactams, fluoroquinolones, tetracyclines, sulfonamides, aminoglycosides, lincosamides, phenicols, macrolides, and others.
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