aders

regulator

Validation StatusSupported

Overview

Mechanism: regulation of efflux pump
Validation Method: transposon insertion sequencing and flow cytometry
Drug Classes: Chlorhexidine, Tigecycline, Omadacycline, Eravacycline, Erythromycin, Tetracycline, Polymyxin b
Organisms: Acinetobacter baumannii, Acinetobacter baumannii ATCC 17978, Acinetobacter nosocomialis, Acinetobacter baumannii AYE, Escherichia coli DH5α
Geographic Location: China, Taiwan
Papers: 6
Databases: Reslit

Papers6

Fluorescence-Based Flow Sorting in Parallel with Transposon Insertion Site Sequencing Identifies Multidrug Efflux Systems in Acinetobacter baumannii.

PMID 27601573 · 2016

The study identified the AdeABC, AdeIJK, and AmvA efflux systems and their regulators, AdeRS, AdeN, and AmvR, as critical for ethidium accumulation and resistance in Acinetobacter baumannii.

Gene Information

Gene Name: aders
Allele: adeRS
Encodes: regulator
Source Database: Reslit
Mechanism: regulation of efflux pump
Organisms Tested In: • Acinetobacter baumannii
Validation Method: transposon insertion sequencing and flow cytometry
Sequence Accession: LT594095|LT594096

Resistance to pentamidine is mediated by AdeAB, regulated by AdeRS, and influenced by growth conditions in Acinetobacter baumannii ATCC 17978.

PMID 29750823 · 2018

The study identifies that the AdeAB efflux pump, regulated by the AdeRS two-component system, mediates resistance to pentamidine, chlorhexidine, and DAPI in Acinetobacter baumannii ATCC 17978. Deletion of adeRS or adeAB reduces resistance to these dicationic compounds, while complementation restores resistance.

Gene Information

Gene Name: aders
Allele: adeRS
Encodes: two-component signal transduction system
Source Database: Reslit
Confers Resistance To: Chlorhexidine
Organisms Tested In: • Acinetobacter baumannii ATCC 17978
Validation Method: deletion and complementation studies

AdeABC Efflux Pump Controlled by AdeRS Two Component System Conferring Resistance to Tigecycline, Omadacycline and Eravacycline in Clinical Carbapenem Resistant Acinetobacter nosocomialis.

PMID 33224122 · 2020

The study shows that the AdeABC efflux pump, regulated by the AdeRS two-component system, contributes to resistance against tigecycline, omadacycline, and eravacycline in clinical carbapenem-resistant Acinetobacter nosocomialis isolates.

Gene Information

Gene Name: aders
Allele: adeRS
Encodes: two-component system
Source Database: Reslit
Mechanism: regulates AdeABC efflux pump
Confers Resistance To: TigecyclineOmadacyclineEravacycline
Organisms Tested In: • Acinetobacter nosocomialis
Geographic Location: Taiwan
Validation Method: complementation of the AdeRS two-component system in wild-type, adeRS operon and adeB gene knockout strains
Sequence Accession: MH321430

The Impact of Omega-3 Fatty Acids on the Evolution of Acinetobacter baumannii Drug Resistance.

PMID 34762519 · 2021

Gene Information

Gene Name: aders
Allele: adeRS
Encodes: two-component regulatory system
Source Database: Reslit
Mechanism: mutated forms confer resistance to erythromycin and tetracycline
Confers Resistance To: ErythromycinTetracycline
Organisms Tested In: • Acinetobacter baumannii
Validation Method: whole-genome sequencing and transcriptional profiling

Emergence of eravacycline heteroresistance in carbapenem-resistant Acinetobacter baumannii isolates in China.

PMID 38601741 · 2024

The study identifies the emergence of eravacycline heteroresistance in carbapenem-resistant Acinetobacter baumannii isolates in China, associated with high expression of AdeABC and AdeRS efflux pumps.

Gene Information

Gene Name: aders
Allele: adeRS
Encodes: transcriptional regulator
Source Database: Reslit
Confers Resistance To: Eravacycline
Organisms Tested In: • Acinetobacter baumannii
Geographic Location: China
Validation Method: asRNA silencing and MIC testing

Contribution of RND superfamily multidrug efflux pumps AdeABC, AdeFGH, and AdeIJK to antimicrobial resistance and virulence factors in multidrug-resistant Acinetobacter baumannii AYE.

PMID 40407309 · 2025

The study identifies the contributions of RND efflux pumps AdeABC, AdeFGH, and AdeIJK to antimicrobial resistance and virulence in multidrug-resistant Acinetobacter baumannii AYE. Disruption of these pumps reduces resistance to multiple antimicrobial classes and affects biofilm formation and virulence.

Gene Information

Gene Name: aders
Allele: adeRS
Encodes: two-component regulatory system
Source Database: Reslit
Mechanism: regulatory system
Confers Resistance To: TetracyclinePolymyxin b
Organisms Tested In: • Acinetobacter baumannii AYE
• Escherichia coli DH5α
Validation Method: gene deletion and susceptibility testing

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