Browse AMR Genes

Explore antimicrobial resistance genes from the literature

ResLit

ahpC

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to ahpC

AMR Rules

Browse AMR rules for ahpC

Overview

Drug Classes: Isoniazid
Organisms: Mycobacterium tuberculosis, Mycobacterium bovis
Papers: 22
Mutations: 37

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
A190S	-	-	Mycobacterium tuberculosis	Isoniazid	Reslit	Candidate
G48A	-	single resistance variant	Mycobacterium tuberculosis	Isoniazid	Card Database	Established
P2S	-	-	Mycobacterium bovis	Isoniazid

Papers22

Molecular characterization of multidrug-resistant Mycobacterium tuberculosis isolated from south-central in China.

PMID 24326341 · 2014

mutations in the ahpC gene are associated with isoniazid resistance

Mutation Information

ahpC: p.A190S

Protein Change: A190S
Organisms: Mycobacterium tuberculosis
Confers Resistance To: Isoniazid
Source Database: Reslit

Integrating standardized whole genome sequence analysis with a global Mycobacterium tuberculosis antibiotic resistance knowledgebase.

PMID 30337678 · 2018

Mycobacterium tuberculosis ahpC mutations confer resistance to isoniazid; CARD accession: CARD:3004921

Mutation Information

ahpC: p.G48A ahpC: p.C81T ahpC: p.C72T ahpC: p.C52T

Protein Change: G48A, C81T, C72T, C52T
Organisms: Mycobacterium tuberculosis
Confers Resistance To: Isoniazid
Effect on Function: single resistance variant
Source Database: Card Database

Genetic diversities and drug resistance in Mycobacterium bovis isolates from zoonotic tuberculosis using whole genome sequencing.

PMID 39487429 · 2024

Mutation Information

ahpC: p.P2S

Protein Change: P2S
Organisms: Mycobacterium bovis
Confers Resistance To: Isoniazid
Source Database: Reslit

Molecular evidence for heterogeneity of the multiple-drug-resistant Mycobacterium tuberculosis population in Scotland (1990 to 1997).

PMID 10074516 · 1999

Mutations in ahpC are associated with isoniazid resistance.

Mutation Information

ahpC: p.T6I

Protein Change: T6I
Confers Resistance To: Isoniazid
Source Database: Reslit

Genotypic distribution of multidrug-resistant and extensively drug-resistant tuberculosis in northern Thailand.

PMID 28706448 · 2017

Mutation Information

ahpC: p.A75V

Protein Change: A75V
Organisms: Mycobacterium tuberculosis
Confers Resistance To: Isoniazid
Source Database: Reslit

Genome analyses of 174 strains of Mycobacterium tuberculosis provide insight into the evolution of drug resistance and reveal potential drug targets.

PMID 33750515 · 2021

Mutation Information

ahpC: p.V130M

Protein Change: V130M
Confers Resistance To: Isoniazid
Source Database: Reslit

Evaluation of the Xpert MTB/XDR test for detection of isoniazid, fluoroquinolones, and second-line injectable drugs resistance to Mycobacterium tuberculosis-Anhui Province, China.

PMID 40938850 · 2025

Mutation Information

ahpC: p.G32A

Protein Change: G32A
Confers Resistance To: Isoniazid
Source Database: Reslit

Tuberculosis drug resistance mutation database.

PMID 19209951 · 2009

Mutation Information

ahpC: c.A-4G ahpC: c.C-20T ahpC: c.C-39T ahpC: c.C-52T ahpC: c.C-54T ahpC: c.G-48A ahpC: c.G-48T ahpC: c.G-5A ahpC: c.G-66A ahpC: c.G-74A ahpC: c.T-44A ahpC: c.T-49G

Nucleotide Change: A-4G, C-20T, C-39T, C-52T, C-54T, G-48A, G-48T, G-5A, G-66A, G-74A, T-44A, T-49G
Organisms: Mycobacterium tuberculosis
Confers Resistance To: Isoniazid
Source Database: ResFinder Database

Performance of an Xpert-based diagnostic algorithm for the rapid detection of drug-resistant tuberculosis among high-risk populations in a low-incidence setting.

PMID 30011319 · 2018

Mutation Information

ahpC: c.C-15T

Nucleotide Change: C-15T
Organisms: Mycobacterium tuberculosis
Confers Resistance To: Isoniazid
Source Database: Reslit

Rapid detection of rifampicin- and isoniazid-resistant Mycobacterium tuberculosis by high-resolution melting analysis.

PMID 20164280 · 2010

Mutation Information

ahpC: c.C-15T

Nucleotide Change: C-15T
Confers Resistance To: Isoniazid
Source Database: Reslit

Investigating resistance in clinical Mycobacterium tuberculosis complex isolates with genomic and phenotypic antimicrobial susceptibility testing: a multicentre observational study.

PMID 35907429 · 2022

Promoter mutation associated with isoniazid resistance.

Mutation Information

ahpC: c.C-52T ahpC: c.G-142A

Nucleotide Change: C-52T, G-142A
Organisms: Mycobacterium tuberculosis
Confers Resistance To: Isoniazid
Source Database: Reslit

Nanopore-based targeted sequencing (NTS) for drug-resistant tuberculosis: an integrated tool for personalized treatment strategies and guidance for new drug development.

PMID 40596923 · 2025

Promoter mutation

Mutation Information

ahpC: c.C-54T

Nucleotide Change: C-54T
Confers Resistance To: Isoniazid
Source Database: Reslit

The genetics and biochemistry of isoniazid resistance in mycobacterium tuberculosis.

PMID 10884617 · 2000

Mutation Information

ahpC: c.C-54T ahpC: c.C-81T ahpC: c.G-48A ahpC: c.G-48T ahpC: c.G-51T ahpC: c.G-74A

Nucleotide Change: C-54T, C-81T, G-48A, G-48T, G-51T, G-74A
Organisms: Mycobacterium tuberculosis
Confers Resistance To: Isoniazid
Source Database: ResFinder Database

The ahpC c-54t compensatory mutation is not always a valid surrogate for isoniazid resistance in Mycobacterium tuberculosis.

PMID 40261011 · 2025

This mutation acts as a compensatory mechanism for fitness defects caused by katG mutations, not directly causing resistance.

Mutation Information

ahpC: c.C-54T

Nucleotide Change: C-54T
Organisms: Mycobacterium tuberculosis
Confers Resistance To: Isoniazid
Source Database: Reslit

Mutations of rpoB, katG, inhA and ahp genes in rifampicin and isoniazid-resistant Mycobacterium tuberculosis in Kyrgyz Republic.

PMID 29566660 · 2018

Mutation Information

ahpC: c.C12T ahpC: c.G9A

Nucleotide Change: C12T, G9A
Organisms: Mycobacterium tuberculosis
Confers Resistance To: Isoniazid
Source Database: Reslit

In vitro modeling of isoniazid resistance mechanisms in Mycobacterium tuberculosis H37Rv.

PMID 37492259 · 2023

Detected in passage 4

Mutation Information

ahpC: p.G7R / c.C21A

Protein Change: G7R
Nucleotide Change: C21A
Organisms: Mycobacterium tuberculosis
Confers Resistance To: Isoniazid
Source Database: Reslit

Prevalence and molecular characterization of multidrug-resistant M. tuberculosis in Jiangxi province, China.

PMID 31086215 · 2019

Mutation Information

ahpC: c.C39A

Nucleotide Change: C39A
Organisms: Mycobacterium tuberculosis
Confers Resistance To: Isoniazid
Source Database: Reslit

A molecular platform for the diagnosis of multidrug-resistant and pre-extensively drug-resistant tuberculosis based on single nucleotide polymorphism mutations present in Colombian isolates of Mycobacterium tuberculosis.

PMID 26841047 · 2016

Mutation Information

ahpC: c.C48G ahpC: c.G44C

Nucleotide Change: C48G, G44C
Organisms: Mycobacterium tuberculosis
Confers Resistance To: Isoniazid
Source Database: Reslit

Initial resistance to companion drugs should not be considered an exclusion criterion for the shorter multidrug-resistant tuberculosis treatment regimen.

PMID 32829049 · 2020

Mutations in ahpC are associated with isoniazid resistance.

Mutation Information

ahpC: p.P81L / c.CCC > CTG ahpC: p.P52L / c.CCC > CTG

Protein Change: P81L, P52L
Nucleotide Change: CCC > CTG
Confers Resistance To: Isoniazid
Source Database: Reslit

Characterization of mutations in multi- and extensive drug resistance among strains of Mycobacterium tuberculosis clinical isolates in Republic of Korea.

PMID 23561273 · 2013

Mutation Information

ahpC: c.G-48A ahpC: c.G-48T

Nucleotide Change: G-48A, G-48T
Organisms: Mycobacterium tuberculosis
Confers Resistance To: Isoniazid
Source Database: ResFinder Database

A comprehensive evaluation of a novel targeted-sequencing workflow for Mycobacterium species identification and anti-tuberculosis drug-resistance detection.

PMID 40552123 · 2025

not covered by TB Pro assay

Mutation Information

ahpC: p.G105D / c.G315A

Protein Change: G105D
Nucleotide Change: G315A
Confers Resistance To: Isoniazid
Source Database: Reslit

Population genetics study of isoniazid resistance mutations and evolution of multidrug-resistant Mycobacterium tuberculosis.

PMID 16870753 · 2006

Mutation Information

ahpC: c.G46A

Nucleotide Change: G46A
Confers Resistance To: Isoniazid
Source Database: Reslit