Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
alanine-tRNA synthetase
Overview
tRNA Synthetase Mutants of Escherichia coli K-12 Are Resistant to the Gyrase Inhibitor Novobiocin.
Mutations in tRNA synthetase genes (alaS, argS, ileS, leuS) and rpoN confer resistance to the gyrase inhibitor novobiocin in Escherichia coli K-12 through the RelA-mediated stringent response.
Genomic insights into the pathogenicity and environmental adaptability of Enterococcus hirae R17 isolated from pork offered for retail sale.
The study identified multiple antimicrobial resistance genes in Enterococcus hirae R17, including genes conferring resistance to beta-lactam antibiotics, lincosamides, streptogramins, pleuromutilins, polymyxins, tetracyclines, and others. Notably, the strain exhibited resistance to bacitracin, ciprofloxacin, daptomycin, erythromycin, and tetracycline.
A role for the stringent response in ciprofloxacin resistance in Pseudomonas aeruginosa.
The study identifies spoT and alaS mutations as key contributors to ciprofloxacin resistance in Pseudomonas aeruginosa, highlighting the role of ppGpp accumulation and translational defects in resistance mechanisms.
Genomic epidemiological analysis reveals new insights into the resurgence of Mycoplasma pneumoniae in China.
The study identifies the A2063G mutation in the 23S rRNA gene as a key determinant of macrolide resistance in Mycoplasma pneumoniae strains in Beijing. Additionally, various mutations in genes associated with genome stability, transcription, translation, and virulence were found to be prevalent in Asian strains.
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