Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
anomeric cell wall amino sugar kinase
Overview
Blocking peptidoglycan recycling in Pseudomonas aeruginosa attenuates intrinsic resistance to fosfomycin.
Research Article
The study identifies amgK, murU, and anmK as genes involved in peptidoglycan recycling that contribute to intrinsic fosfomycin resistance in Pseudomonas aeruginosa. Deletion of these genes significantly increases fosfomycin susceptibility.
Identification of Drug Resistance Determinants in a Clinical Isolate of Pseudomonas aeruginosa by High-Density Transposon Mutagenesis.
Research Article
The study identifies several nonessential genes involved in β-lactam resistance in Pseudomonas aeruginosa, including ampC, mltG, mepM1, amgK, and ygfB, which contribute to the induction of ampC expression and resistance against meropenem and cefepime.
Synergism of imipenem with fosfomycin associated with the active cell wall recycling and heteroresistance in Acinetobacter calcoaceticus-baumannii complex.
Research Article
The study identifies carbapenemase genes blaOXA-24, blaOXA-23, and blaOXA-58 along with blaIMP in various Acinetobacter isolates, contributing to carbapenem resistance. It also highlights the role of cell wall recycling pathways and heteroresistance in modulating the effectiveness of imipenem-fosfomycin synergy.
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