amiC

N-acetylmuramoyl-L-alanine amidase

Validation StatusCandidate

Overview

Mechanism: inhibition triggers tolerance
Validation Method: knock-in approach
Drug Classes: Imipenem, Ciprofloxacin, Vancomycin, Gentamicin
Organisms: Escherichia coli, Klebsiella pneumoniae, Streptococcus pneumoniae
Papers: 2
Databases: Reslit
Mutations: 2

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
G402R	-	-	-	Imipenem	Reslit	Candidate
-	G1204A	-	-	Imipenem	Reslit	Candidate

Papers2

Chemogenomic Screen for Imipenem Resistance in Gram-Negative Bacteria.

PMID 31744905 · 2019

The study identified several genes and mutations associated with imipenem resistance in Gram-negative bacteria, including rpoD, amiC, nlpD, wecA, slt, and oprD, through mutagenesis and functional validation experiments.

Gene Information

Gene Name: amiC
Allele: amiC
Encodes: N-acetylmuramoyl-L-alanine amidase
Source Database: Reslit
Confers Resistance To: Imipenem
Organisms Tested In: • Escherichia coli
• Klebsiella pneumoniae
Validation Method: knock-in approach
Sequence Accession: PRJNA244551|PRJNA244567|PRJNA316664

A genome-wide atlas of antibiotic susceptibility targets and pathways to tolerance.

PMID 35672367 · 2022

The study identified genes like cozEb and amiE/amiC that influence antibiotic sensitivity through various mechanisms, including cell wall synthesis and efflux pump inhibition, demonstrating the complexity of bacterial tolerance and resistance.

Gene Information

Gene Name: amiC
Allele: amiC
Encodes: oligopeptide transporter
Source Database: Reslit
Mechanism: inhibition triggers tolerance
Confers Resistance To: CiprofloxacinVancomycinGentamicin
Organisms Tested In: • Streptococcus pneumoniae
Validation Method: knockout in S. pneumoniae + antibiotic accumulation analysis

Browse AMR Genes

amiC

Mutations

Gene Information

Gene Information