Browse AMR Genes

Explore antimicrobial resistance genes from the literature

ampG

Murein recycling transporter

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to ampG

Browse AMR rules for ampG

Validation StatusSupported

Overview

Mechanism: Impairs murein recycling
Validation Method: Transposon insertion analysis
Drug Classes: Ampicillin, Carbenicillin, Fosfomycin, Beta-lactamase inhibitors, Ceftazidime/avibactam
Organisms: Escherichia coli, Pseudomonas aeruginosa, Escherichia coli O157:H7, Acinetobacter baumannii, Mucilaginibacter sp. 21p, Vibrio cholerae
Geographic Location: Brazil, Thailand
Papers: 8
Databases: Reslit
Mutations: 16

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
Q131P	-	loss of function	Pseudomonas aeruginosa, Escherichia coli, Vibrio cholerae, Acinetobacter baumannii	Ampicillin	Reslit	Candidate
Q131R	-	loss of function	Escherichia coli, Vibrio cholerae, Pseudomonas aeruginosa, Acinetobacter baumannii	Ampicillin	Reslit	Candidate
Q131H	-	loss of function	Pseudomonas aeruginosa, Escherichia coli, Vibrio cholerae, Acinetobacter baumannii

Papers8

1

Genetic architecture of intrinsic antibiotic susceptibility.

PMID 19462005 · 2009

The study identifies multiple genes and mutations that contribute to antibiotic tolerance in E. coli, revealing a large mutational target size for increasing drug resistance. Key findings include the role of genes involved in electron transport, flagella synthesis, and efflux pumps in modulating susceptibility to various antibiotics.

Gene Information

Gene Name: ampG
Allele: ampG
Encodes: Murein recycling transporter
Source Database: Reslit
Mechanism: Impairs murein recycling
Confers Resistance To: Ampicillin
Organisms Tested In: • Escherichia coli
Validation Method: Transposon insertion analysis

2

The regulatory repertoire of Pseudomonas aeruginosa AmpC ß-lactamase regulator AmpR includes virulence genes.

PMID 22479525 · 2012

AmpR is a global regulator in P. aeruginosa that influences the expression of over 500 genes, including those involved in β-lactam resistance, virulence, and biofilm formation.

Gene Information

Gene Name: ampG
Allele: ampG
Encodes: transporter
Source Database: Reslit
Organisms Tested In: • Pseudomonas aeruginosa
Validation Method: qPCR
Sequence Accession: NCBI:NC_002516

3

Effect of β-lactam antibiotic resistance gene expression on the radio-resistance profile of E. coli O157:H7.

PMID 30534620 · 2018

The study shows that the expression of ampC and ampG genes in E. coli O157:H7 contributes to radioresistance, particularly when the bacteria are adapted to carbenicillin. Mutants lacking these genes showed increased sensitivity to irradiation.

Gene Information

Gene Name: ampG
Allele: ampG
Encodes: permease
Source Database: Reslit
Confers Resistance To: Carbenicillin
Organisms Tested In: • Escherichia coli O157:H7
Validation Method: expression analysis and irradiation resistance

4

Synergism of imipenem with fosfomycin associated with the active cell wall recycling and heteroresistance in Acinetobacter calcoaceticus-baumannii complex.

PMID 34997148 · 2022

The study identifies carbapenemase genes blaOXA-24, blaOXA-23, and blaOXA-58 along with blaIMP in various Acinetobacter isolates, contributing to carbapenem resistance. It also highlights the role of cell wall recycling pathways and heteroresistance in modulating the effectiveness of imipenem-fosfomycin synergy.

Gene Information

Gene Name: ampG
Allele: ampG
Encodes: transporter
Source Database: Reslit
Confers Resistance To: Fosfomycin
Organisms Tested In: • Acinetobacter baumannii
Geographic Location: Thailand
Validation Method: RT-PCR and antibiotic susceptibility testing

5

Mucilaginibacter sp. Strain Metal(loid) and Antibiotic Resistance Isolated from Estuarine Soil Contaminated Mine Tailing from the Fundão Dam.

PMID 35205220 · 2022

The study identifies multiple AMR genes in Mucilaginibacter sp. 21p, including genes for resistance to quinolones, aminoglycosides, beta-lactamases, sulfonamides, tetracyclines, daptomycin, arsenic, zinc, manganese, cobalt, and cadmium. These genes are part of efflux pumps and other resistance mechanisms, indicating the strain's adaptability to metal(loid) and antibiotic stressors in contaminated environments.

Gene Information

Gene Name: ampG
Allele: ampG
Encodes: penicillin-binding protein
Source Database: Reslit
Confers Resistance To: Beta-lactamase inhibitors
Organisms Tested In: • Mucilaginibacter sp. 21p
Geographic Location: Brazil
Validation Method: annotation via RAST and PATRIC
Sequence Accession: SUB8286515|PRJNA667924