Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
RND transporter
Overview
Investigation of aminoglycoside resistance inducing conditions and a putative AmrAB-OprM efflux system in Burkholderia vietnamiensis.
Genomic and RT-qPCR analysis of trimethoprim-sulfamethoxazole and meropenem resistance in Burkholderia pseudomallei clinical isolates.
The study identifies a mutation in the amrR gene, a regulator of the AmrAB-OprA efflux pump, which leads to meropenem resistance in Burkholderia pseudomallei. This mutation was experimentally validated through genomic analysis and RT-qPCR.
Full pathogen characterisation: species identification including the detection of virulence factors and antibiotic resistance genes via multiplex DNA-assays.
The study presents a DNA microarray-based assay for the simultaneous detection of 44 sepsis-relevant bacterial pathogens, 360 virulence factors, and 409 antibiotic resistance genes. The assay was evaluated with 14 multidrug-resistant strains, including all ESKAPE pathogens.
Genomic characterization of an environmental Burkholderia thailandensis strain from Kerala, India reveals virulence and antimicrobial resistance signatures.
The study identifies multiple antimicrobial resistance genes in an environmental Burkholderia thailandensis strain, including efflux pumps and a β-lactamase, suggesting potential multidrug resistance.
Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate-binding pocket.
The hydrophilic patch in the substrate-binding pocket of BpeB and BpeF influences their substrate specificity, with mutations in this region altering resistance profiles to various antibiotics.
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