amrab

efflux pump

Validation StatusSupported

Overview

Mechanism: efflux
Validation Method: deletion of amrB in the PAO1-derived laboratory mutant, which resulted in the restoration of aminoglycoside sensitivity
Drug Classes: Aminoglycoside, Macrolide, Doxycycline, Chloramphenicol, Fluoroquinolone, Trimethoprim/sulfamethoxazole
Organisms: Pseudomonas aeruginosa, Burkholderia pseudomallei, Burkholderia thailandensis
Papers: 3
Databases: Reslit

Papers3

Characterization of a Pseudomonas aeruginosa efflux pump contributing to aminoglycoside impermeability.

PMID 10582892 · 1999

The study identifies the amrAB genes as part of an efflux pump system in Pseudomonas aeruginosa that contributes to aminoglycoside impermeability. Deletion of amrB reversed the aminoglycoside resistance phenotype, confirming the role of amrAB in this resistance mechanism.

Gene Information

Gene Name: amrab
Allele: amrAB
Encodes: efflux pump
Source Database: Reslit
Mechanism: efflux
Confers Resistance To: Aminoglycoside
Organisms Tested In: • Pseudomonas aeruginosa
Validation Method: deletion of amrB in the PAO1-derived laboratory mutant, which resulted in the restoration of aminoglycoside sensitivity
Sequence Accession: AF147719

MexXY multidrug efflux system of Pseudomonas aeruginosa.

PMID 23233851 · 2012

The study characterizes the MexXY multidrug efflux system in Pseudomonas aeruginosa, highlighting its role in aminoglycoside resistance. It also identifies related efflux systems in other bacteria such as AcrD in E. coli, AmrAB-OprA in B. pseudomallei, and AdeABC in A. baumannii.

Gene Information

Gene Name: amrab
Allele: amrAB
Encodes: RND-type multidrug efflux pump
Source Database: Reslit
Confers Resistance To: AminoglycosideMacrolide
Organisms Tested In: • Burkholderia pseudomallei
Validation Method: experimental validation in B. pseudomallei

Interplay between three RND efflux pumps in doxycycline-selected strains of Burkholderia thailandensis.

PMID 24386333 · 2013

The study identifies three RND efflux pumps (AmrAB-OprA, BpeAB-OprB, and BpeEF-OprC) that contribute to multidrug resistance in doxycycline-selected strains of Burkholderia thailandensis. Overexpression of these pumps leads to resistance against tetracyclines, chloramphenicol, and trimethoprim/sulfamethoxazole.

Gene Information

Gene Name: amrab
Allele: amrAB
Encodes: efflux pump
Source Database: Reslit
Mechanism: overexpression leading to multidrug resistance
Confers Resistance To: DoxycyclineChloramphenicolFluoroquinoloneTrimethoprim/sulfamethoxazole
Organisms Tested In: • Burkholderia thailandensis
Validation Method: MIC testing and gene expression analysis

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