Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
nucleotidyltransferase
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| ANT(3")-Ii | Reslit | 1 | Streptomycin, Spectinomycin | Serratia marcescens | - | 2013 | - | - |
| ANT(3'')-IIa | Card DatabaseReference Gene Catalog |
| 25 |
| Streptomycin, Spectinomycin +4 |
| Acinetobacter baumannii +14 |
| Chongqing|China, USA|Brazil|Japan|Thailand|Pakistan, Germany, Kenya, India, Argentina|Australia|Brazil|China|India|United States, Nigeria, Australia, Alexandria, Egypt, UK, Beijing, Egypt, Fiji, Cambodia, East China, United States|Minnesota, Europe |
| 2017, 2019, 2020, 2021, 2022, 2023, 2024, 2025 |
| EEX02086|CAJ77832|ABO10616|ENV65326|ENW14756|ADY83642|ENU37733|ENV80847|ESK39014|ENX32354|ENU91137|NC_010410|CP000521|NZ_CP010397 |
| ABO10616.2 |
| ant(3")-II | Reslit | 1 | Aminoglycoside | Acinetobacter baumannii | desert plant | 2020 | CP028138|CP028139 | - |
| ant(3″)-IIa | Reslit | 2 | Aminoglycoside | Salmonella enterica serovar Agona +1 | Australia | 2020, 2023 | CP033347|CP039170 | - |
| ANT (3')-IIa | Reslit | 1 | Aminoglycoside | Klebsiella pneumoniae | China | 2021 | JAGFMM000000000|JAGFMN000000000|JAGFMO000000000|JAGFMP000000000|JAGFMQ000000000|JAGFMR000000000|JAGFMS000000000|JAGFMT000000000 | - |
| ant(3''-IIa | Reslit | 1 | Streptomycin | Acinetobacter baumannii ACC002 | - | 2021 | - | - |
| ANT(3″)-IIa | Reslit | 1 | Aminoglycoside | Klebsiella pneumoniae | China | 2022 | CP093151|CP093152|CP093153 | - |
| ant(3’’)-II | Reslit | 1 | Aminoglycoside | Acinetobacter baumannii | Alexandria, Egypt | 2023 | PRJNA856145 | - |
| ANT(3”)-IIa | Reslit | 2 | Aminoglycoside | Escherichia coli +1 | global|China, China | 2023, 2024 | NCBI:ERR326600|NCBI:CP050736|NCBI:AE006471|NCBI:CP090536 | - |
| ant(3”)-IIa | Reslit | 1 | Aminoglycoside | Pseudomonas aeruginosa | Southern California, USA | 2023 | CP079845 | - |
| ant(3'')-II | Reslit | 1 | Aminoglycoside | Acinetobacter baumannii | Alexandria, Egypt | 2023 | PRJNA856145 | - |
| ant (3'')-IIa | Reslit | 1 | Aminoglycoside | Acinetobacter baumannii | China | 2024 | CP096712.1|CP010399.1|CP010370.2|JQ001791.1|KJ547696.1|KM923969.1|CP046901.1|CP076810.1|KP890934.1|Q241792.1 | - |
| ant(3'' )-IIa | Reslit | 1 | Aminoglycoside | Acinetobacter baumannii | Vietnam | 2025 | BAAGBB010000001–BAAGBB010000013|BAAGBC010000001–BAAGBC010000009|BAAGBD010000001–BAAGBD010000007 | - |
Domain dissection and characterization of the aminoglycoside resistance enzyme ANT(3")-Ii/AAC(6')-IId from Serratia marcescens.
The study characterizes the bifunctional aminoglycoside resistance enzyme ANT(3")-Ii/AAC(6')-IId from Serratia marcescens, identifying its nucleotidyltransferase and acetyltransferase activities against various aminoglycosides.
A new subclass of intrinsic aminoglycoside nucleotidyltransferases, ANT(3")-II, is horizontally transferred among Acinetobacter spp. by homologous recombination.
The study identifies a new subclass of intrinsic aminoglycoside nucleotidyltransferases, ANT(3")-II, which provides resistance to streptomycin and spectinomycin in Acinetobacter species. These genes are horizontally transferred among different Acinetobacter species through homologous recombination.
A new subclass of intrinsic aminoglycoside nucleotidyltransferases, ANT(3")-II, is horizontally transferred among Acinetobacter spp. by homologous recombination.
The study identifies a new subclass of intrinsic aminoglycoside nucleotidyltransferases, ANT(3")-II, which provides resistance to streptomycin and spectinomycin in Acinetobacter species. These genes are horizontally transferred among different Acinetobacter species through homologous recombination.
Comparative genomic analysis and multi-drug resistance differences of Acinetobacter baumannii in Chongqing, China.
The study identified 19 drug resistance genes in 10 multidrug-resistant Acinetobacter baumannii strains, with efflux pump genes being the most prevalent. Key genes included aacA4, which had a 19-bp deletion associated with aminoglycoside resistance, and other genes like TEM-1, OXA-23, and ANT(3'')-IIa.
Acinetobacter baumannii NCIMB8209: a Rare Environmental Strain Displaying Extensive Insertion Sequence-Mediated Genome Remodeling Resulting in the Loss of Exposed Cell Structures and Defensive Mechanisms.
The study identifies several AMR genes in the environmental strain Acinetobacter baumannii NCIMB8209, including blaOXA-78, blaADC-154, carO, oprD/occAB1, ant(3")-II, and catB, which confer resistance to carbapenems, beta-lactams, aminoglycosides, and chloramphenicol.
Whole-Genome Sequence Analysis of an Extensively Drug-Resistant Salmonella enterica Serovar Agona Isolate from an Australian Silver Gull (Chroicocephalus novaehollandiae) Reveals the Acquisition of Multidrug Resistance Plasmids.
The study identifies multiple antimicrobial resistance genes in a multidrug-resistant Salmonella enterica serovar Agona isolate from a silver gull, including bla CTX-M-55, dfrA14, sul3, qnrS1, tet(A), bla TEM-1, and others, indicating the acquisition of multidrug resistance plasmids.
Analysis of Complete Genome Sequence of Acinetobacter baumannii Strain ATCC 19606 Reveals Novel Mobile Genetic Elements and Novel Prophage.
The study identifies the sul2 sulfonamide resistance gene and the intrinsic ant(3")-IIa aminoglycoside resistance gene in Acinetobacter baumannii strain ATCC 19606, confirming its resistance to sulfamethoxazole, streptomycin, and spectinomycin.
WGS based analysis of acquired antimicrobial resistance in human and non-human Acinetobacter baumannii isolates from a German perspective.
The study identified multiple acquired antimicrobial resistance (AMR) genes in 189 German Acinetobacter baumannii strains, including blaADC.25, blaOXA-23, blaOXA-66, ant(3")-IIa, sul2, tet.B, mph.E, msr.E, and blaTEM, which confer resistance to various antibiotics such as aminoglycosides, cephalosporins, carbapenems, sulfonamides, tetracyclines, and macrolides.
Molecular Epidemiological Analysis of ST11-K64 Extensively Drug-Resistant Klebsiella pneumoniae Infections Outbreak in Intensive Care and Neurosurgery Units Based on Whole-Genome Sequencing.
The study identified multiple AMR genes in ST11-K64 XDRKp strains, including beta-lactamases, aminoglycoside resistance genes, and efflux pumps, contributing to extensive drug resistance.
Mouse pneumonia model by Acinetobacter baumannii multidrug resistant strains: Comparison between intranasal inoculation, intratracheal instillation and oropharyngeal aspiration techniques.
The study identified various AMR genes in two multidrug-resistant Acinetobacter baumannii strains, ACC001 and ACC002, including aminoglycoside resistance genes, tetracycline resistance genes, beta-lactamases, and sulfonamide resistance genes. These genes contribute to resistance against multiple antibiotics such as gentamicin, tobramycin, tetracycline, penicillins, cephalosporins, and sulfonamides.
Antimicrobial Resistance and Virulence Characteristics of Klebsiella pneumoniae Isolates in Kenya by Whole-Genome Sequencing.
The study identified several AMR genes in K. pneumoniae isolates from Kenya, including blaCTX-M-15, blaTEM-181, blaOXA-181, blaNDM-1, mcr-8, armA, rmtF, aac(6')-Ib-cr, aph(3")-ib, aph(6)-id, dfrA, sul2, qnrB, tetA, and catII, which confer resistance to various antibiotics such as beta-lactams, carbapenems, aminoglycosides, fluoroquinolones, tetracyclines, and chloramphenicol.
Coexistence of Multidrug Resistance and Virulence in a Single Conjugative Plasmid from a Hypervirulent Klebsiella pneumoniae Isolate of Sequence Type 25.
The study identifies a conjugative plasmid pCY814036-iucA carrying multidrug resistance genes and virulence factors, and another plasmid pCY814036-KPC2 harboring bla KPC-2 and rmtB, contributing to carbapenem resistance and hypervirulence in a Klebsiella pneumoniae isolate.
Aeromonas species isolated from aquatic organisms, insects, chicken, and humans in India show similar antimicrobial resistance profiles.
The study identified multiple antimicrobial resistance (AMR) genes in Aeromonas species isolated from various hosts in India, including beta-lactamases (bla OXA-12, bla OXA-427, bla OXA-724, bla OXA-780, bla FOX-2, bla FOX-4, bla FOX-5, bla FOX-7, bla AQU-2, bla MOX-7), metallo-beta-lactamases (cphA3, cphA4, cphA5, cphA8, ImiH), and other resistance genes (dfrA12, aadA2, ANT(3")-IIa, sul1). Additionally, multidrug efflux pump genes (mdtH, zntA, emrD, blR, crp) were found to contribute to AMR in these isolates.
A survey on antimicrobial resistance genes of frequently used probiotic bacteria, 1901 to 2022.
The study identified various antimicrobial resistance genes in probiotic bacteria, highlighting the presence of mobile genetic elements and the potential for horizontal gene transfer.
High Genetic Diversity of Carbapenem-Resistant Acinetobacter baumannii Isolates Recovered in Nigerian Hospitals in 2016 to 2020.
The study identified blaOXA-23 and blaNDM-1 as the most common carbapenem resistance genes in Acinetobacter baumannii isolates from Nigerian hospitals, along with several other AMR genes and mutations contributing to multidrug resistance.
Dominance of Escherichia coli sequence types ST73, ST95, ST127 and ST131 in Australian urine isolates: a genomic analysis of antimicrobial resistance and virulence linked to F plasmids.
The study identified various antimicrobial resistance genes in E. coli isolates from Australian urine samples, including blaCTX-M-15, blaCTX-M-14, blaTEM-28, sul1, sul2, sul3, dfrA17, dfrA5, dfrA1, dfrB4, tetA, tetB, mphA, cmlA1, cmlA5, catB3, sat2, qnrD1, fosA7, aac(3)-IId, aac(3)-IIe, aph(3')-IIa, aph(6)-Id, ant(3'')-IIa, intI1, and intI2. These genes were associated with resistance to various antibiotics such as beta-lactams, sulfonamides, trimethoprim, tetracycline, macrolides, chloramphenicol, streptothricin, quinolones, fosfomycin, and aminoglycosides.
Molecular characterization of multidrug resistant Acinetobacter baumannii clinical isolates from Alexandria, Egypt.
The study identified various AMR genes in multidrug-resistant Acinetobacter baumannii isolates from Alexandria, Egypt, including bla OXA-51-like variants, bla OXA-23, bla NDM-1, bla PER-7, bla GES-like, and others, highlighting the widespread resistance to beta-lactams, aminoglycosides, tetracyclines, and other antibiotics.
Molecular characterization of multidrug resistant Acinetobacter baumannii clinical isolates from Alexandria, Egypt.
The study identified various AMR genes in multidrug-resistant Acinetobacter baumannii isolates from Alexandria, Egypt, including bla OXA-51-like variants, bla OXA-23, bla NDM-1, bla PER-7, bla GES-like, and others, highlighting the widespread resistance to beta-lactams, aminoglycosides, tetracyclines, and other antibiotics.
Characterization of the pig lower respiratory tract antibiotic resistome.
The study characterizes the antibiotic resistome of the pig lower respiratory tract microbiome, identifying 372 ARGs, including tetracycline, aminoglycoside, and phenicol resistance genes, and highlights the role of MGEs in their dissemination.
Domestically Acquired NDM-1-Producing Pseudomonas aeruginosa, Southern California, USA, 2023
The study reports a case of domestically acquired NDM-1-producing Pseudomonas aeruginosa in a transplant patient in southern California, highlighting the presence of multiple resistance genes including blaNDM-1, blaOXA-10, blaOXA-488, blaPDC-35, blaPME-1, aac(6')-Ib9, ant(3”)-IIa, aph(3′)-IIb, aph(3′)-VIa, catB3, catB7, cmlA9, fosA, tet(D), and sul1.
Prioritization of Critical Factors for Surveillance of the Dissemination of Antibiotic Resistance in Pseudomonas aeruginosa: A Systematic Review.
The study identifies 25 critical mobile antibiotic resistance genes (ARGs) in Pseudomonas aeruginosa, including genes such as sul1, qacEΔ1, aac(6′)-Ib, bla VIM-1, and others, which are associated with various antibiotic classes and are linked to mobile genetic elements (MGEs).
Phenotypic and genomic characterization of Pseudomonas aeruginosa isolates recovered from catheter-associated urinary tract infections in an Egyptian hospital.
The study identified multiple AMR genes and mutations in Pseudomonas aeruginosa isolates from catheter-associated urinary tract infections in Egypt, including beta-lactamases, aminoglycoside-modifying enzymes, quinolone resistance proteins, and efflux pump systems. Additionally, a pBT2436-like megaplasmid was detected, which contributes to multidrug resistance.
Short-duration selective decontamination of the digestive tract infection control does not contribute to increased antimicrobial resistance burden in a pilot cluster randomised trial (the ARCTIC Study).
The study found no significant increase in clinically relevant antimicrobial resistance gene burden in critically ill children treated with SDD-enhanced infection control compared to standard care.
Plasmid content of carbapenem resistant Acinetobacter baumannii isolates belonging to five International Clones collected from hospitals of Alexandria, Egypt.
The study characterizes various AMR genes in carbapenem-resistant Acinetobacter baumannii isolates, including blaOXA-23, blaPER-7, blaGES-11, blaGES-35, aph(3')-VI, aac(6')-Ib, sul1, sul2, mph(E), msr(E), armA, strA, strB, cmlA5, arr-2, ant(3'')-II, aadA1-pm, tet(B), tet(39), qacEΔ1, and dfrA7.
Genomic insights and antimicrobial resistance profiles of CRKP and non-CRKP isolates in a Beijing geriatric medical center: emphasizing the bla(KPC-2) carrying high-risk clones and their spread.
The study identifies blaKPC-2 as a key gene in carbapenem resistance among CRKP isolates, along with other resistance genes such as rmtB, APH(3')-Ia, and QnrB4. It also highlights the prevalence of ST11-KL47-OL101 clones and the role of plasmid pKpnR03_2 in the spread of resistance.
Emergence of carbapenem resistant gram-negative pathogens with high rate of colistin resistance in Egypt: A cross sectional study to assess resistance trends during the COVID-19 pandemic.
The study identified high prevalence of carbapenem resistance in Gram-negative pathogens in Egypt, with bla NDM and bla OXA-48-like being the most prevalent carbapenemase genes. Plasmid-mediated quinolone resistance genes qnrS and qnrB were also detected. Additionally, several aminoglycoside resistance genes and integron-associated gene cassettes were characterized.
Molecular and clinical epidemiology of carbapenem resistant Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacterales in Fiji: a multicentre prospective observational study.
The study identified several carbapenem-resistant genes, including bla OXA-23, bla OXA-66, bla NDM-1, bla OXA-50, bla OXA-395, bla NDM-7, and bla NDM-5, in various bacterial species in Fiji.
A panel of genotypically and phenotypically diverse clinical Acinetobacter baumannii strains for novel antibiotic development.
The study identifies various AMR genes and mutations in a diverse panel of Acinetobacter baumannii strains, including bla OXA-23, bla OXA-24, bla OXA-58, bla NDM-1, and mutations in gyrA and parC associated with fluoroquinolone resistance.
Characterization of a Salmonella enterica serovar Typhimurium lineage with rough colony morphology and multidrug resistance.
The study identifies a multidrug-resistant Salmonella enterica serovar Typhimurium lineage with a rough colony morphology, carrying multiple AMR genes including aminoglycoside, beta-lactam, chloramphenicol, sulfonamide, tetracycline, and quinolone resistance genes. A specific mutation (-44G > T) in the csgD promoter was found to upregulate biofilm-related genes.
Bacterial Genomics for National Antimicrobial Resistance Surveillance in Cambodia.
The study identified various AMR genes and mutations in bacterial isolates from Cambodia, including extended-spectrum beta-lactamase genes (blaCTX-M-15, blaCTX-M-27, blaCTX-M-55), carbapenemase genes (blaOXA-23, blaNDM-1, blaOXA-58, blaOXA-66), and colistin resistance genes (mcr-1, mcr-3, mcr-7, mcr-9). Additionally, mutations in gyrA (S83F) and parC (S84L) were found to confer fluoroquinolone resistance in Salmonella enterica serovars Paratyphi A and Typhi.
Molecular Epidemiology and Genetic Characterization of Carbapenem-Resistant Acinetobacter baumannii Isolates from the ICU of a Tertiary Hospital in East China.
The study identified 48 antimicrobial resistance genes (ARGs) in 39 carbapenem-resistant Acinetobacter baumannii (CRAB) isolates, including blaOXA-66, blaOXA-23, blaADC-30, blaADC-73, gyrA, ant(3")-IIa, aph(3")-Ib, aph(6)-Id, tetB, tetR, sul1, sul2, LpsB, LpxC, and LpxA, which confer resistance to various antibiotics such as carbapenems, cephalosporins, fluoroquinolones, aminoglycosides, tetracycline, and sulfonamides.
Proximity-Ligation Metagenomic Sequence Analysis Reveals That the Antibiotic Resistome Makes Significant Transitions During Municipal Wastewater Treatment.
The study reveals significant transitions in the antibiotic resistome during municipal wastewater treatment, highlighting the presence of various ARGs in untreated wastewater and their reduced abundance in treated samples. Notably, certain ARGs like blaOXA, mef(A), and msr(D) were prevalent in untreated wastewater, while others like aph(3")-Ib, aph(6)-Id, mef(C), mph(A), and mph(G) were more prominent in activated sludge samples.
A decade of genomic and phenotypic adaptation of carbapenem-resistant Acinetobacter baumannii.
The study identifies various AMR genes and mutations in carbapenem-resistant Acinetobacter baumannii isolates, including blaOXA-23, blaOXA-51-like, and several aminoglycoside resistance genes, contributing to extensive drug resistance.
Genomic Characterization and Antibiotic Resistance Profiles of Acinetobacter baumannii Isolates From Intensive Care Units in Vietnam.
The study identifies multiple AMR genes in three CRAB isolates, including blaOXA-23, blaOXA-66, blaADC-198, blaADC-73, and various aminoglycoside modifying enzymes, efflux pumps, and sulfonamide resistance genes, highlighting the extensive multidrug resistance in these isolates.
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