ResLit

ant(3'')-Ia

aminoglycoside adenyltransferase

NCBI Pathogen Isolates
Bacterial genomes carrying this gene
NCBI Reference Gene Catalog
Known alleles and reference sequences
UniProt
Protein entries specific to ant(3'')-Ia
AMR Rules
Browse AMR rules for ant(3'')-Ia
Curation StatusNot Validated

Overview

Drug Classes
streptomycin, spectinomycin, STREPTOMYCIN, SPECTINOMYCIN
Organisms
Vibrio cholerae O1, Pasteurella multocida, Escherichia coli +2 more
Alleles
4
Papers
3
Allele Variants4
AllelePapersDrug ClassesOrganismsCountriesYearsStatus
ant(3")-1a1streptomycin, spectinomycinVibrio cholerae O1Guinea-Bissau2000Not Validated
AadA147STREPTOMYCIN, SPECTINOMYCIN +2Pasteurella multocida +1Belgium|Germany2005Not Validated
AadA176STREPTOMYCIN, SPECTINOMYCINAeromonas media-2012Not Validated
AadA6STREPTOMYCIN, SPECTINOMYCINuncultured bacterium--Not Validated
Papers3
1

Class 1 Integron-Borne, Multiple-Antibiotic Resistance Encoded by a 150-Kilobase Conjugative Plasmid in Epidemic Vibrio cholerae O1 Strains Isolated in Guinea-Bissau.

PMID 11015401 · 2000

The study identifies a 150-kb conjugative plasmid in Vibrio cholerae O1 strains from Guinea-Bissau that carries class 1 integron-borne gene cassettes encoding resistance to trimethoprim (dhfrXII) and aminoglycosides (ant(3")-1a).

Gene Information

Gene Name
ant(3'')-Ia
Allele
ant(3")-1a
Encodes
aminoglycoside adenyltransferase
Validation Method
PCR amplification and sequencing of class 1 integrons

Confers Resistance To

streptomycinspectinomycin

Organisms Tested In

• Vibrio cholerae O1

Isolation Details

Country
Guinea-Bissau
2

Novel spectinomycin/streptomycin resistance gene, aadA14, from Pasteurella multocida.

PMID 15980396 · 2005

Gene Information

Gene Name
ant(3'')-Ia
Allele
AadA14
Encodes
ANT(3'')-Ia family aminoglycoside nucleotidyltransferase AadA14

Mechanism

Enzymatic modification

Confers Resistance To

STREPTOMYCINSPECTINOMYCIN

Organisms Tested In

• Pasteurella multocida
3

Novel spectinomycin/streptomycin resistance gene, aadA14, from Pasteurella multocida.

PMID 15980396 · 2005

Gene Information

Gene Name
ant(3'')-Ia
Allele
AadA14
Encodes
ANT(3'')-Ia family aminoglycoside nucleotidyltransferase AadA14

Mechanism

Enzymatic modification

Confers Resistance To

STREPTOMYCINSPECTINOMYCIN

Organisms Tested In

• Pasteurella multocida
4

Novel spectinomycin/streptomycin resistance gene, aadA14, from Pasteurella multocida.

PMID 15980396 · 2005

The study identifies a novel spectinomycin/streptomycin resistance gene, aadA14, from Pasteurella multocida, which was experimentally validated to confer resistance to both antibiotics.

Gene Information

Gene Name
ant(3'')-Ia
Allele
AadA14
Encodes
aminoglycoside adenylyltransferase
Validation Method
cloning in E. coli + MIC testing

Confers Resistance To

spectinomycinstreptomycin

Organisms Tested In

• Pasteurella multocida
• Escherichia coli

Isolation Details

Country
Belgium|Germany
5

Novel spectinomycin/streptomycin resistance gene, aadA14, from Pasteurella multocida.

PMID 15980396 · 2005

Gene Information

Gene Name
ant(3'')-Ia
Allele
AadA14
Encodes
ANT(3'')-Ia family aminoglycoside nucleotidyltransferase AadA14

Mechanism

Enzymatic modification

Confers Resistance To

STREPTOMYCINSPECTINOMYCIN

Organisms Tested In

• Pasteurella multocida
6

Novel spectinomycin/streptomycin resistance gene, aadA14, from Pasteurella multocida.

PMID 15980396 · 2005

Gene Information

Gene Name
ant(3'')-Ia
Allele
AadA14
Encodes
ANT(3'')-Ia family aminoglycoside nucleotidyltransferase AadA14

Mechanism

Enzymatic modification

Confers Resistance To

STREPTOMYCINSPECTINOMYCIN

Organisms Tested In

• Pasteurella multocida
7

Novel spectinomycin/streptomycin resistance gene, aadA14, from Pasteurella multocida.

PMID 15980396 · 2005

Gene Information

Gene Name
ant(3'')-Ia
Allele
AadA14
Encodes
ANT(3'')-Ia family aminoglycoside nucleotidyltransferase AadA14

Mechanism

Enzymatic modification

Confers Resistance To

STREPTOMYCINSPECTINOMYCIN

Organisms Tested In

• Pasteurella multocida
8

Novel spectinomycin/streptomycin resistance gene, aadA14, from Pasteurella multocida.

PMID 15980396 · 2005

Gene Information

Gene Name
ant(3'')-Ia
Allele
AadA14
Encodes
ANT(3'')-Ia family aminoglycoside nucleotidyltransferase AadA14

Mechanism

Enzymatic modification

Confers Resistance To

STREPTOMYCINSPECTINOMYCIN

Organisms Tested In

• Pasteurella multocida
9

Novel gene cassettes and integrons in antibiotic-resistant bacteria isolated from urban wastewaters.

PMID 22127350 · 2012

Gene Information

Gene Name
ant(3'')-Ia
Allele
AadA17
Encodes
ANT(3'')-Ia family aminoglycoside nucleotidyltransferase AadA17

Mechanism

Enzymatic modification

Confers Resistance To

STREPTOMYCINSPECTINOMYCIN

Organisms Tested In

• Aeromonas media
10

Novel gene cassettes and integrons in antibiotic-resistant bacteria isolated from urban wastewaters.

PMID 22127350 · 2012

Gene Information

Gene Name
ant(3'')-Ia
Allele
AadA17
Encodes
ANT(3'')-Ia family aminoglycoside nucleotidyltransferase AadA17

Mechanism

Enzymatic modification

Confers Resistance To

STREPTOMYCINSPECTINOMYCIN

Organisms Tested In

• Aeromonas media
11

Novel gene cassettes and integrons in antibiotic-resistant bacteria isolated from urban wastewaters.

PMID 22127350 · 2012

Gene Information

Gene Name
ant(3'')-Ia
Allele
AadA17
Encodes
ANT(3'')-Ia family aminoglycoside nucleotidyltransferase AadA17

Mechanism

Enzymatic modification

Confers Resistance To

STREPTOMYCINSPECTINOMYCIN

Organisms Tested In

• Aeromonas media
12

Novel gene cassettes and integrons in antibiotic-resistant bacteria isolated from urban wastewaters.

PMID 22127350 · 2012

Gene Information

Gene Name
ant(3'')-Ia
Allele
AadA17
Encodes
ANT(3'')-Ia family aminoglycoside nucleotidyltransferase AadA17

Mechanism

Enzymatic modification

Confers Resistance To

STREPTOMYCINSPECTINOMYCIN

Organisms Tested In

• Aeromonas media
13

Novel gene cassettes and integrons in antibiotic-resistant bacteria isolated from urban wastewaters.

PMID 22127350 · 2012

Gene Information

Gene Name
ant(3'')-Ia
Allele
AadA17
Encodes
ANT(3'')-Ia family aminoglycoside nucleotidyltransferase AadA17

Mechanism

Enzymatic modification

Confers Resistance To

STREPTOMYCINSPECTINOMYCIN

Organisms Tested In

• Aeromonas media
14

Novel gene cassettes and integrons in antibiotic-resistant bacteria isolated from urban wastewaters.

PMID 22127350 · 2012

Gene Information

Gene Name
ant(3'')-Ia
Allele
AadA17
Encodes
ANT(3'')-Ia family aminoglycoside nucleotidyltransferase AadA17

Mechanism

Enzymatic modification

Confers Resistance To

STREPTOMYCINSPECTINOMYCIN

Organisms Tested In

• Aeromonas media
15
PMID N/A

Gene Information

Gene Name
ant(3'')-Ia
Allele
AadA
Encodes
ANT(3'')-Ia family aminoglycoside nucleotidyltransferase AadA

Confers Resistance To

STREPTOMYCINSPECTINOMYCIN

Organisms Tested In

• uncultured bacterium
16
PMID N/A

Gene Information

Gene Name
ant(3'')-Ia
Allele
AadA
Encodes
ANT(3'')-Ia family aminoglycoside nucleotidyltransferase AadA

Confers Resistance To

STREPTOMYCINSPECTINOMYCIN

Organisms Tested In

• uncultured bacterium
17
PMID N/A

Gene Information

Gene Name
ant(3'')-Ia
Allele
AadA
Encodes
ANT(3'')-Ia family aminoglycoside nucleotidyltransferase AadA

Confers Resistance To

STREPTOMYCINSPECTINOMYCIN

Organisms Tested In

• uncultured bacterium
18
PMID N/A

Gene Information

Gene Name
ant(3'')-Ia
Allele
AadA
Encodes
ANT(3'')-Ia family aminoglycoside nucleotidyltransferase AadA

Confers Resistance To

STREPTOMYCINSPECTINOMYCIN

Organisms Tested In

• uncultured bacterium
19
PMID N/A

Gene Information

Gene Name
ant(3'')-Ia
Allele
AadA
Encodes
ANT(3'')-Ia family aminoglycoside nucleotidyltransferase AadA

Confers Resistance To

STREPTOMYCINSPECTINOMYCIN

Organisms Tested In

• uncultured bacterium
20
PMID N/A

Gene Information

Gene Name
ant(3'')-Ia
Allele
AadA
Encodes
ANT(3'')-Ia family aminoglycoside nucleotidyltransferase AadA

Confers Resistance To

STREPTOMYCINSPECTINOMYCIN

Organisms Tested In

• uncultured bacterium
Comments (0)

No comments yet. Be the first to comment!