ant(4')-IIa

The ant(4')-IIa gene from Pseudomonas aeruginosa was characterized as encoding an aminoglycoside nucleotidyltransferase that confers resistance to amikacin and tobramycin.

Gene Information

Gene Name: ant(4')-IIa
Allele: ANT(4')-IIa
Encodes: aminoglycoside nucleotidyltransferase
Source Database: Reslit
Mechanism: modifies aminoglycoside antibiotics by adding a nucleotide group, reducing their efficacy
Confers Resistance To: tobramycin
Organisms Tested In: • Pseudomonas aeruginosa
Validation Method: site-directed mutagenesis and DNA hybridization studies

Nucleotide sequence analysis and DNA hybridization studies of the ant(4')-IIa gene from Pseudomonas aeruginosa.

Research Article

PMID 8494365 · 1993

Gene Information

Gene Name: ant(4')-IIa
Allele: ANT(4')-IIa
Encodes: aminoglycoside nucleotidyltransferase ANT(4')-IIa
Source Database: Reference Gene Catalog
Mechanism: Enzymatic modification
Confers Resistance To: ISEPAMICINTOBRAMYCINKANAMYCINAMIKACIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: M98270.1
Protein Accession: AAA25717.1
Notes: ARO:3002624

Nucleotide sequence analysis and DNA hybridization studies of the ant(4')-IIa gene from Pseudomonas aeruginosa.

Research Article

PMID 8494365 · 1993

Gene Information

Gene Name: ant(4')-IIa
Allele: ANT(4')-IIa
Encodes: aminoglycoside nucleotidyltransferase ANT(4')-IIa
Source Database: ResFinder Database
Mechanism: Enzymatic modification
Confers Resistance To: ISEPAMICINTOBRAMYCINKANAMYCINAMIKACIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: M98270.1
Protein Accession: AAA25717.1
Notes: ARO:3002624

Nucleotide sequence analysis and DNA hybridization studies of the ant(4')-IIa gene from Pseudomonas aeruginosa.

Research Article

PMID 8494365 · 1993

Gene Information

Gene Name: ant(4')-IIa
Allele: ANT(4')-IIa
Encodes: aminoglycoside nucleotidyltransferase ANT(4')-IIa, ANT(4')
Source Database: Card Database
Mechanism: Enzymatic modification, antibiotic inactivation
Confers Resistance To: ISEPAMICINTOBRAMYCINKANAMYCINAMIKACIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: M98270.1
Protein Accession: AAA25717.1
Notes: ARO:3002624

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ant(4')-IIa

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aminoglycoside nucleotidyltransferase

NCBI Pathogen Isolates

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NCBI Reference Gene Catalog

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UniProt

Protein entries specific to ant(4')-IIa

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Validation StatusConfirmed2+ DBs

Overview

Mechanism: Enzymatic modification
Validation Method: site-directed mutagenesis and DNA hybridization studies
Drug Classes: ISEPAMICIN, TOBRAMYCIN, AMIKACIN, KANAMYCIN
Organisms: Pseudomonas aeruginosa
Papers: 2
Databases: Card DatabaseReference Gene CatalogResFinder DatabaseReslit

Papers2

Molecular genetics of aminoglycoside resistance genes and familial relationships of the aminoglycoside-modifying enzymes.

Review

PMID 8385262 · 1993

Gene Information

Gene Name: ant(4')-IIa
Allele: ant(4')-IIa
Source Database: ResFinder Database
Mechanism: Enzymatic modification
Confers Resistance To: ISEPAMICINTOBRAMYCINAMIKACIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: M98270

Nucleotide sequence analysis and DNA hybridization studies of the ant(4')-IIa gene from Pseudomonas aeruginosa.

Research Article

PMID 8494365 · 1993

The ant(4')-IIa gene from Pseudomonas aeruginosa was characterized as encoding an aminoglycoside nucleotidyltransferase that confers resistance to amikacin and tobramycin.

Gene Information

Gene Name: ant(4')-IIa
Allele: ANT(4')-IIa
Encodes: aminoglycoside nucleotidyltransferase
Source Database: Reslit
Mechanism: modifies aminoglycoside antibiotics by adding a nucleotide group, reducing their efficacy
Confers Resistance To: tobramycin
Organisms Tested In: • Pseudomonas aeruginosa
Validation Method: site-directed mutagenesis and DNA hybridization studies

Nucleotide sequence analysis and DNA hybridization studies of the ant(4')-IIa gene from Pseudomonas aeruginosa.

Research Article

PMID 8494365 · 1993

Gene Information

Gene Name: ant(4')-IIa
Allele: ANT(4')-IIa
Encodes: aminoglycoside nucleotidyltransferase ANT(4')-IIa
Source Database: Reference Gene Catalog
Mechanism: Enzymatic modification
Confers Resistance To: ISEPAMICINTOBRAMYCINKANAMYCINAMIKACIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: M98270.1
Protein Accession: AAA25717.1
Notes: ARO:3002624

Nucleotide sequence analysis and DNA hybridization studies of the ant(4')-IIa gene from Pseudomonas aeruginosa.

Research Article

PMID 8494365 · 1993

Gene Information

Gene Name: ant(4')-IIa
Allele: ANT(4')-IIa
Encodes: aminoglycoside nucleotidyltransferase ANT(4')-IIa
Source Database: ResFinder Database
Mechanism: Enzymatic modification
Confers Resistance To: ISEPAMICINTOBRAMYCINKANAMYCINAMIKACIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: M98270.1
Protein Accession: AAA25717.1
Notes: ARO:3002624

Nucleotide sequence analysis and DNA hybridization studies of the ant(4')-IIa gene from Pseudomonas aeruginosa.

Research Article

PMID 8494365 · 1993

Gene Information

Gene Name: ant(4')-IIa
Allele: ANT(4')-IIa
Encodes: aminoglycoside nucleotidyltransferase ANT(4')-IIa, ANT(4')
Source Database: Card Database
Mechanism: Enzymatic modification, antibiotic inactivation
Confers Resistance To: ISEPAMICINTOBRAMYCINKANAMYCINAMIKACIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: M98270.1
Protein Accession: AAA25717.1
Notes: ARO:3002624

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ant(4')-IIa

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