The study identified aac(6')-aph(2"), ant(4')-I, and aph(3')-III genes as the primary aminoglycoside-modifying enzymes in methicillin-resistant Staphylococcus aureus (MRSA) isolates in Japan, with varying prevalence rates.

The study identified various AMR genes in MRSA isolates from Iranian ICUs, including genes conferring resistance to aminoglycosides, macrolides, tetracycline, and mupirocin.

The study identified several AMR genes in multidrug-resistant staphylococci from high-frequency touched surfaces in London, including blaZ, qacA/B, dfrC, norA, ant(4')-Ib, AAC(6')-Ie-APH(2")-Ia, fusB, msrA, ermC, mphC, tetK, mupA, cat, dfrG, lnuA, fusC, aph3-IIIa, sat4A, vgaA, and others. These genes conferred resistance to various antibiotics such as penicillin, fusidic acid, mupirocin, tetracycline, erythromycin, and chloramphenicol.

The study characterizes the resistance mechanisms of aminoglycosides, focusing on the interactions between the synthesized compound 7 and aminoglycoside-modifying enzymes such as AAC-(6′), APH-(3′), and ANT-(4′).

The study identifies silenced antibiotic resistance genes in Staphylococcus aureus, highlighting the prevalence of transient antibiotic resistance due to mutations that inactivate resistance genes, leading to apparent susceptibility but potential re-emergence of resistance.

The study reports the complete genome sequence of a methicillin-resistant Staphylococcus schleiferi strain (SS4) from a dog with otitis externa in Korea, identifying antimicrobial resistance genes such as mecA, aac(6')-aph(2''), ant(4')-Ib, and blaZ.

The study identified several AMR genes including mecA, vanA, vanB, aac(6')-Ie-aph(2'')-Ia, ant(4')-Ia, and aph(3')-IIIa in staphylococci isolated from healthy children in Eastern Uganda. These genes were associated with resistance to methicillin, vancomycin, and aminoglycosides.

The study identified high prevalence of multidrug-resistant ST239 isolates with strong biofilm-producing ability. Key AMR genes included mupA, fusC, erm(A), erm(C), ant(4')-Ia, aac(6')-Ie/aph(2''), aph(3')-IIIa, tetM, and tetK.

All 31 MRSP isolates were multidrug-resistant, showing resistance to penicillin, macrolides, lincosamides, aminoglycosides, tetracycline, and trimethoprim-sulfamethoxazole. Key resistance genes identified include blaZ, ermB, msr(A/B), aac(6')-Ie-aph(2'')-Ia, aph(3')-IIIa, ant(4')-Ia, tetM, tetK, and dfrG.

The study identified several AMR genes and mutations in ESKAPEE pathogens, including vanA, vanB, blaTEM, blaSHV, blaCTX-M, blaOXA, blaVEB, blaVIM, blaNDM, aac(6')-Ib, aadB, ermC, qnrS1, and gyrA mutations, highlighting the prevalence of multidrug resistance in these isolates.

The study identifies several antimicrobial resistance genes, including aad(6), tetK, bla, erm, and cat, which confer resistance to streptomycin, tetracycline, chloramphenicol, and erythromycin. These genes were transferred via phage-mediated transduction in Staphylococcus epidermidis.

The study identifies a mupirocin-resistant, methicillin-susceptible Staphylococcus aureus clone (ST121) associated with skin and soft tissue infections in Greece, carrying resistance genes mupA, fusB, and ant(4')-Ia.

The study identified several AMR genes in Staphylococcus isolates from Novosibirsk, Russia, including mecA, blaZ, aac(6')-Ie-aph(2'')-Ia, ant(4')-Ia, aph(3')-IIIa, ermA, ermC, msrA, norA, dfrC, fosB, and mphC, which confer resistance to beta-lactams, aminoglycosides, macrolides, quinolones, and other antibiotics.

The study characterizes various tetracycline and methicillin-resistant Staphylococcus aureus genetic lineages circulating in Spanish hospitals, identifying multiple AMR genes including blaZ, tetK, tetL, tetM, ermC, ermB, ant(4')-Ia, aac(6')-Ie-aph(2'')-Ia, mupA, and fusB.

The study identified various antimicrobial resistance genes in Staphylococcus aureus isolates from cattle, farm workers, and their environment, highlighting the potential for transmission between hosts and the need for monitoring AMR in One Health contexts.

The study identified various AMR genes in Staphylococcus isolates from orthopedic implant-associated infections, including mecA, blaZ, aminoglycoside modifying enzymes, and erythromycin resistance genes, highlighting the prevalence of multidrug resistance among these isolates.

The study identified multidrug-resistant Staphylococcus aureus in bovine milk samples, highlighting the presence of resistance genes blaZ, ermC, rpoB, and ant(4')-la, which confer resistance to penicillin, macrolides, rifampicin, and spectinomycin, respectively.

The study identifies numerous AMR genes in Mycobacteroides abscessus complex, highlighting the widespread presence of resistance to multiple antibiotic classes, including beta-lactams, aminoglycosides, glycopeptides, and others. Key findings include the detection of beta-lactamases like blaLAP-1 and blaTLA-2, 23S rRNA methyltransferases such as erm(33), erm(43), and erm(44), and various aminoglycoside modifying enzymes. Additionally, vancomycin resistance genes like vanA, vanB, and vanC were identified, along with efflux pump genes contributing to multidrug resistance.

The study identified several AMR genes in Enterococcus, Pseudomonas, and Staphylococcus sp. strains, including beta-lactamases, chloramphenicol acetyltransferases, macrolide resistance determinants, efflux pump genes, and sulfonamide resistance proteins. These genes contribute to resistance against various antibiotics such as beta-lactams, chloramphenicol, aminoglycosides, tetracyclines, and sulfonamides.

The study identified multiple antibiotic resistance genes (ARGs) in manure samples from a swine finishing facility, highlighting the prevalence of resistance to tetracyclines, macrolides, aminoglycosides, and other antibiotics. Key genes included tet(M), lnuA, erm(35), aadS, mphB, dfrG, vga-type ABC-F, lsa-type ABC-F, msr-type ABC-F, optrA, and others, primarily found in Firmicutes, Proteobacteria, and Bacteroidota. These genes were associated with resistance mechanisms such as target alteration, antibiotic inactivation, and efflux pumps.

The study identified several AMR genes in S. aureus isolates from diabetic foot infections, including blaZ, erm(B), erm(A), msrA, tet(M), tet(K), tet(L), aac(6')-aph(2"), ant(4')-Ia, and fexA. These genes conferred resistance to various antibiotics such as penicillin, erythromycin, tetracycline, gentamicin, tobramycin, and chloramphenicol.

The study identified various AMR genes in ESBL-producing E. coli isolates from agricultural farms and open markets in Edo State, Nigeria, including blaTEM, blaCTX-M-1, blaCTX-M-15, tetM, tetA, tetB, sul1, sul2, sul3, ant(4')-Ia, aacC(3)-1, qnrA, qnrB, qnrC, qnrS, cat::pC194, cat::pC221, intI1, and intI2. These genes conferred resistance to multiple antibiotics, indicating the presence of multidrug-resistant E. coli in the studied environments.

The study identifies various AMR genes including blaZ, dfrA, dfrG, ermB, catA, aac6′-aph2″, tet(M), dfrK, and ant4′ in Staphylococcus aureus and Staphylococcus pseudintermedius isolates. Additionally, a mutation in grlA (S80F) was found to confer fluoroquinolone resistance.

The study identifies aminoglycoside-modifying enzymes aac(6')-Ib, aph(3')-IIIa, and ant(4')-la as responsible for gentamicin resistance in Staphylococcus aureus and Enterococcus faecalis. Palmitoleic acid enhances gentamicin efficacy against resistant strains by increasing uptake.

The study found no significant increase in clinically relevant antimicrobial resistance gene burden in critically ill children treated with SDD-enhanced infection control compared to standard care.

The study characterizes the resistome of Gram-positive bacteria causing keratitis, identifying several AMR genes and mutations associated with resistance to antibiotics such as macrolides, aminoglycosides, tetracyclines, and fluoroquinolones. Key findings include the prevalence of ermA, ermB, ermC, mphC, msrA, msrD, mecA, ant(9)-Ia, ant(4′)-Ib, aac(6′)-aph(2″), aph(3′)-III, fosB, tetK, tetM, dfrG, dfrC, and dfrE genes, along with mutations in gyrA and parC contributing to fluoroquinolone resistance.

The study identified various antibiotic resistance genes and mutations in Staphylococcus aureus strains from different sources, including beta-lactam resistance genes (blaZ, mecA), aminoglycoside resistance genes (ant(4')-Ia, aph(3')-Ia), tetracycline resistance genes (tetM, tetK), and the bleO gene for bleomycin resistance. Mutations in gyrA and grlA were also found to contribute to quinolone resistance.

The study identified various AMR genes including blaZ, mecA, erm(A), erm(C), erm(T), mph(C), msr(A), vga(A), lsaB, ant4′, aac6′-aph2″, tet(K), tet(M), dfrA, dfrG, catPC221, and mupA in CoNS isolates from healthy dogs and dog-owners. Additionally, a linezolid-resistant S. epidermidis isolate was found to have multiple amino acid substitutions in 50S ribosomal proteins L3 and L4.

The study identifies multiple AMR genes and mutations in CoNS isolates from various hosts, highlighting the spread of multidrug resistance and the role of mobile genetic elements in the dissemination of resistance traits.

The study identified a rich diversity of antibiotic resistance genes (ARGs) in the intestinal microbiota of preterm infants, with beta-lactam, MLS, and tetracycline resistance being the most prevalent. Key ARGs included ermC, ermB, mecA, TEM-4, ANT(4')-Ib, isaA, vgaC, and oqxB, which were associated with various bacterial species and drug classes.

The study identified antibiotic resistance genes aph(3')-IIIa, tetM, and tetL in certain Enterococcus strains, indicating resistance to gentamicin and tetracycline. However, most strains showed susceptibility to clinically significant antibiotics.

The study identified multiple AMR genes in odontogenic abscesses using NGS, including genes conferring resistance to tetracyclines, macrolides, lincosamides, aminoglycosides, chloramphenicol, sulfonamides, penicillins, and others. Notably, Fusobacterium showed resistance to clindamycin.

The study identified several AMR genes in Staphylococcus hominis, including erm(C), tetK, acc(6')-Ie aph(2''), aph(3')-IIIa, ant(4')-Ia, msr(B), mph(C), lnu(A), and vga, which confer resistance to various antibiotics such as macrolides, lincosamides, streptogramins, tetracyclines, and aminoglycosides. The majority of the strains exhibited multidrug resistance.

The study identified an increase in multidrug-resistant (MDR) and extensively drug-resistant (XDR) Pseudomonas aeruginosa isolates in Northwestern Transylvania, Romania, between 2022 and 2023. Key AMR genes included bla OXA-50, sul1, ermB, mexA, mexB, bla VIM-1, aac(6′)-II, ant(4′)-Ia, aac(3)-I, aac(6′)-Im, aph(2″)-Ib, tetA, tetC, tetK, qnrB, ermC, mphC, fosA, nfsA, nfsB, ampC, and TEM-1.

The study identified aac(6')-Ie-aph(2''), aph(2'')-Ib, and ant(4')-Ia genes as the most prevalent aminoglycoside-modifying enzymes in MRSA and MSSA isolates from Ardabil, Iran.

The study identified several antimicrobial resistance genes in Staphylococcus aureus isolates from ovine mastitis in Jordan, including blaZ, aph(3')-III, ant(4')-Ia, str, and mecA. These genes conferred resistance to penicillin G, kanamycin, streptomycin, and methicillin.

The study identified several AMR genes in methicillin-resistant Staphylococcus aureus (MRSA) isolates from pets, dairies, and humans, including mecA, tet(M), tet(K), erm(C), erm(A), mph(C), msr(A), blaR1, blaZ, blaI_of_Z, blaPC1, vga(A), fosB-Saur, sat4, bleO, ant(9)-Ia, aph(2'')-Ih, aph(3')-IIIa, and ant(4')-Ia. These genes confer resistance to various antibiotics such as methicillin, tetracycline, erythromycin, macrolides, lincomycin, fosfomycin, streptothricin, bleomycin, spectinomycin, amikacin, gentamicin, kanamycin, tobramycin, and others.

The study identified aac(6)-Ie-aph(2)-Ia, ant(6)-Ia, and ant(4′)-Ia genes conferring resistance to aminoglycosides in Lactobacillaceae strains, along with a rpsL mutation causing streptomycin resistance.

The study identified several AMR genes in S. epidermidis isolates from AML patients, including mecA, mecR1, qacA, ermC, tetM, cfrA, ANT(4′)-Ib, blaZ, dfrG, cat, and mecI, which were associated with increased resistance to various antibiotics.

The study identified multiple antibiotic resistance genes in multidrug-resistant Staphylococcus haemolyticus and Enterococcus faecalis isolates from public gymnasium equipment, highlighting their potential to resist various antibiotics and posing a health risk in communal environments.

The study identifies the ant(4')-Ia gene as responsible for tobramycin resistance in gentamicin-susceptible methicillin-resistant Staphylococcus aureus (GS-MRSA) strains.