Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
aminoglycoside nucleotidyltransferase
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| ANT(9)-Ia | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 34 | Spectinomycin, Aminoglycoside +3 |
| United States, Switzerland, Scotland|Australia|England, Pacific region|Hawaii, Europe, Brazil, Russia, Canada|United Kingdom|Alberta, China, Europe|Asia|North America|South America|Brazil, Germany, France, Netherlands, Shanghai, China, Kenya, UK, USA, Japan, Canterbury, New Zealand, Thailand |
| 1985, 2009, 2010, 2011, 2019, 2021, 2022, 2023, 2024, 2025 |
| NC_002951 |
| CAA26428.1 |
| ant9 | Reslit | 2 | Spectinomycin, Aminoglycoside | Streptococcus agalactiae +1 | China | 2016, 2021 | PRJNA324749|HG939456 | - |
| ant(9)-Ia | ResFinder Database | 1 | SPECTINOMYCIN | Staphylococcus aureus, Enterococcus faecalis | - | 1985 | X02588, M69221 | - |
| ant(9) | Reslit | 4 | Aminoglycoside | Campylobacter coli +3 | global, Minnesota, Russia, Europe | 2020, 2022, 2025 | - | - |
| ANT(9) | Reslit | 1 | Aminoglycoside | Streptococcus suis | United States | 2023 | AM946016|CP031377|CP031378|CP030017|CP030022|CP031379|CP030020|CP030021|CP030023|CP030015|CP030016|CP030030|CP030010|CP030011|CP030012|CP030013|CP030014|CP012345|CP012346|CP012347|CP012348|CP012349|CP012350|CP012351|CP012352|CP012353 | - |
| ant9′ | Reslit | 1 | Tobramycin | Staphylococcus aureus +9 | Spain|Portugal|Germany|UK|Switzerland|Thailand|Italy | 2023 | JQ246438.1|AM159501.1|FM207105|KR230047.1|NC_029025|NC_018281|NC_007054|NC_022914|NC_020490|NC_019915|NC_019914|NC_028862|NC_018284|NC_007056|NC_007055 | - |
VanA-type Staphylococcus aureus strain VRSA-7 is partially dependent on vancomycin for growth.
The study identifies the vanA gene cluster, erm(A), and ant(9)-Ia as conferring resistance to glycopeptides and aminoglycosides in VRSA-7. A mutation in the ddl gene (N308K) impairs d-alanine:d-alanine ligase activity, making the strain partially dependent on vancomycin for growth.
Aminoglycoside modifying enzymes.
The paper discusses various aminoglycoside modifying enzymes, particularly focusing on AAC(6')-Ib, AAC(6')-Ib-cr, and AAC(6')-Ib 11, which confer resistance to aminoglycosides like amikacin and gentamicin, and in some cases, quinolones.
The increase of methicillin-resistant Staphylococcus aureus (MRSA) and the presence of an unusual sequence type ST49 in slaughter pigs in Switzerland.
The study identifies the presence of methicillin-resistant Staphylococcus aureus (MRSA) in slaughter pigs in Switzerland, highlighting the emergence of the unusual sequence type ST49. It reports various AMR genes such as mecA, blaZ, tet(M), tet(K), erm(A), erm(C), ant(9)-Ia, str, dfr(G), and vga(A)v, which confer resistance to β-lactams, tetracycline, macrolides, lincosamides, streptogramins B, spectinomycin, streptomycin, trimethoprim, and tiamulin.
Genomic Analysis Reveals Multi-Drug Resistance Clusters in Group B Streptococcus CC17 Hypervirulent Isolates Causing Neonatal Invasive Disease in Southern Mainland China.
The study identifies multiple antibiotic resistance genes, including tetO, ermB, ant6, aphA, ant9, and lnuB, in Group B Streptococcus CC17 isolates from China, highlighting the emergence of multi-drug resistance in these hypervirulent strains.
Nucleotide sequence of a spectinomycin adenyltransferase AAD(9) determinant from Staphylococcus aureus and its relationship to AAD(3") (9).
Nucleotide sequence of a spectinomycin adenyltransferase AAD(9) determinant from Staphylococcus aureus and its relationship to AAD(3") (9).
Nucleotide sequence of a spectinomycin adenyltransferase AAD(9) determinant from Staphylococcus aureus and its relationship to AAD(3") (9).
Nucleotide sequence of a spectinomycin adenyltransferase AAD(9) determinant from Staphylococcus aureus and its relationship to AAD(3") (9)., Cloning and nucleotide base sequence analysis of a spectinomycin adenyltransferase AAD(9) determinant from Enterococcus faecalis.
Emergence of an Australian-like pstS-null vancomycin resistant Enterococcus faecium clone in Scotland.
The study identifies multiple AMR genes in Scottish vancomycin-resistant Enterococcus faecium (VREfm) isolates, including aac(6')-Ii, aac(6')-aph(2''), ermB, pbp5-R, vanA, ant(9)-Ia, tetL, and dfrG. These genes confer resistance to various antibiotics, highlighting the multidrug-resistant nature of the isolates.
Genomic Analysis Reveals the Genetic Determinants Associated With Antibiotic Resistance in the Zoonotic Pathogen Campylobacter spp. Distributed Globally.
The study identified 15 acquired genes associated with resistance to five distinct antibiotic classes in Campylobacter spp., including novel beta-lactamase genes blaOXA-493 and blaOXA-576, and characterized mutations in gyrA, rpsL, and 23S rRNA that confer resistance to fluoroquinolones, streptomycin, and macrolides, respectively.
A Longitudinal Evaluation of the Bacterial Pathogens Colonizing Chronic Non-Healing Wound Sites at a United States Military Treatment Facility in the Pacific Region.
The study identified multiple antimicrobial resistance genes in bacterial isolates from chronic non-healing wounds, including beta-lactamases, aminoglycoside modifying enzymes, macrolide resistance genes, and others. These genes were found in various bacterial species such as E. coli, S. aureus, P. aeruginosa, and others.
SWINE VIRULENCE ASSESSMENT
This study analyzed the virulence and genomic characteristics of nine United States Streptococcus suis isolates, identifying genomic attributes associated with swine-virulent phenotypes. However, no specific AMR genes or mutations were experimentally validated in this paper.
A platform for detecting cross-resistance in antibacterial drug discovery.
The study presents a cross-resistance platform (CRP) consisting of 28 Staphylococcus aureus strains with defined resistance genotypes, designed to detect cross-resistance between established and novel antibacterial agents. The CRP includes various AMR genes and mutations that confer resistance to multiple antibiotic classes.
Danofloxacin Treatment Alters the Diversity and Resistome Profile of Gut Microbiota in Calves.
Danofloxacin treatment altered the gut microbiota diversity and resistome profile in calves, increasing the frequency and host range of several antimicrobial resistance genes (ARGs) such as aac(6')-Ib, ant9, tet40, tetW, ermF, tetL, and tetX.
Antimicrobial resistance determinants in silage.
The study identified 16 antimicrobial resistance genes (ARGs) in silage samples, highlighting their potential to spread through the food chain and contribute to antimicrobial resistance.
Comparative Phenotypic and Genomic Features of Staphylococci from Sonication Fluid of Orthopedic Implant-Associated Infections with Poor Outcome.
The study identified various AMR genes in Staphylococcus isolates from orthopedic implant-associated infections, including mecA, blaZ, aminoglycoside modifying enzymes, and erythromycin resistance genes, highlighting the prevalence of multidrug resistance among these isolates.
Genomic diversity of genus Limosilactobacillus.
The study identified 18 AMR genes in Limosilactobacillus species, primarily in L. reuteri from animal sources, including tetracycline, aminoglycoside, macrolide-lincosamide-streptogramin, and lincomycin resistance genes.
The impacts of viral infection and subsequent antimicrobials on the microbiome-resistome of growing pigs.
The study identified ermG as a gene that increased in abundance in the feces of treated pigs compared to those that did not receive post-PRRS antimicrobials, indicating its role in macrolide, lincosamide, and streptogramin B resistance.
Whole-Genome Analysis of Staphylococcus aureus Isolates from Ready-to-Eat Food in Russia.
The study identified multiple antimicrobial resistance (AMR) genes in Staphylococcus aureus isolates from ready-to-eat food in Russia, including blaZ, mecA, inuA, cat, ermC, dfrG, dfrK, aaC, aaD, ant(9)-Ia, tet(K), tet(cluster), erm(A), erm(C), cat(pC194), and fexA. These genes conferred resistance to various antibiotics such as penicillins, lincosamides, phenicols, macrolides, aminoglycosides, tetracyclines, and fluoroquinolones.
Exploring the mobilome and resistome of Enterococcus faecium in a One Health context across two continents.
The study identifies various AMR genes in Enterococcus faecium, including vanA, vanB, ermB, ermT, ermA, aad(6), aph(3')-IIIa, aac(6')-Ie-aph(2')-Ia, sat-4, tetM, tet(W/N/W), dfrG, dfrF, lnuB, optrA, and lsaE, which are associated with different habitats and geographic locations.
Persistence of transferable oxazolidinone resistance genes in enterococcal isolates from a swine farm in China.
The study identified the persistence of transferable oxazolidinone resistance genes, particularly optrA, poxtA, and cfr(D), in enterococcal isolates from a swine farm in China. These genes were found to confer resistance to linezolid, tedizolid, chloramphenicol, and florfenicol.
How Streptococcus suis escapes antibiotic treatments.
The study characterizes various AMR genes and mutations in Streptococcus suis, highlighting resistance to beta-lactams, macrolides, lincosamides, streptogramins, amphenicols, pleuromutilins, tetracyclines, sulfonamides, trimethoprim, and fluoroquinolones.
Distribution Patterns of Antibiotic Resistance Genes and Their Bacterial Hosts in a Manure Lagoon of a Large-Scale Swine Finishing Facility.
The study identified multiple antibiotic resistance genes (ARGs) in manure samples from a swine finishing facility, highlighting the prevalence of resistance to tetracyclines, macrolides, aminoglycosides, and other antibiotics. Key genes included tet(M), lnuA, erm(35), aadS, mphB, dfrG, vga-type ABC-F, lsa-type ABC-F, msr-type ABC-F, optrA, and others, primarily found in Firmicutes, Proteobacteria, and Bacteroidota. These genes were associated with resistance mechanisms such as target alteration, antibiotic inactivation, and efflux pumps.
Comparative virulence and antimicrobial resistance distribution of Streptococcus suis isolates obtained from the United States.
The study identified several antimicrobial resistance (AMR) genes in Streptococcus suis isolates from the United States, including ble, tetO, ermB, lsaE, lnuB, ant(9)-Ia, and ant(6)-Ia, which confer resistance to glycopeptides, tetracyclines, macrolide-lincosamide-streptogramin B, pleuromutilins, and aminoglycosides respectively.
Plasmid-Coded Linezolid Resistance in Methicillin-Resistant Staphylococcus aureus from Food and Livestock in Germany.
Two linezolid-resistant MRSA strains from pigs in Germany were identified, both harboring plasmid-encoded cfr genes. These strains also had additional AMR genes, indicating multidrug resistance.
Phenotypic and Genotypic Virulence Characterisation of Staphylococcus pettenkoferi Strains Isolated from Human Bloodstream and Diabetic Foot Infections.
The study characterizes several AMR genes and mutations in Staphylococcus pettenkoferi strains, including blaZ, mecA, ant(9)-Ia, tet(K), ermA, vgaA, and fosB, as well as mutations in rpoB, gyrA, glrA, and grlB.
Farming Practice Influences Antimicrobial Resistance Burden of Non-Aureus Staphylococci in Pig Husbandries.
The study found that organic and alternative pig farming practices are associated with reduced antimicrobial resistance (AMR) in non-aureus staphylococci (NAS) compared to conventional farming. Specific AMR genes such as mecA, blaZ, blaPC1, and others were more prevalent in conventional farms, while organic farms showed lower levels of AMR genes for aminoglycosides, phenicols, and tetracyclines.
Panton-Valentine Leukocidin-Positive CC398 MRSA in Urban Clinical Settings, the Netherlands.
The study identified PVL-positive CC398 MRSA strains in the Netherlands, highlighting their potential for community acquisition and the importance of genomic surveillance for early detection.
Inter-species diversity and functional genomic analyses of closed genome assemblies of clinically isolated, megaplasmid-containing Enterococcus raffinosus Er676 and ATCC49464.
The study characterizes antimicrobial resistance genes in Enterococcus raffinosus strains Er676 and ATCC49464, identifying genes such as tetM, ant(9)-Ia, ant(6)-Ia, ermA, efrA, efrB, optrA, and fexA, which confer resistance to tetracyclines, aminoglycosides, macrolides, oxazolidinones, and phenicols.
Metagenomic assembly is the main bottleneck in the identification of mobile genetic elements.
The study evaluated the performance of tools for identifying mobile genetic elements (MGEs) and antimicrobial resistance genes (ARGs) in metagenomic data. It found that metagenomic assembly is the main bottleneck in accurately identifying MGEs and ARGs, with moderate precision and sensitivity for plasmids, phages, IS elements, and ARGs.
Metagenomic identification of pathogens and antimicrobial-resistant genes in bacterial positive blood cultures by nanopore sequencing.
The study identified various antimicrobial resistance (AMR) genes in bacterial positive blood cultures using nanopore sequencing, demonstrating the effectiveness of this method in detecting resistance mechanisms and pathogens quickly.
Canine Staphylococcaceae circulating in a Kenyan animal shelter.
The study identified various AMR genes in Staphylococcaceae strains isolated from dogs in a Kenyan animal shelter, including tetracycline, beta-lactam, and aminoglycoside resistance genes.
Short-duration selective decontamination of the digestive tract infection control does not contribute to increased antimicrobial resistance burden in a pilot cluster randomised trial (the ARCTIC Study).
The study found no significant increase in clinically relevant antimicrobial resistance gene burden in critically ill children treated with SDD-enhanced infection control compared to standard care.
Characterization of the resistome and predominant genetic lineages of Gram-positive bacteria causing keratitis.
The study characterizes the resistome of Gram-positive bacteria causing keratitis, identifying several AMR genes and mutations associated with resistance to antibiotics such as macrolides, aminoglycosides, tetracyclines, and fluoroquinolones. Key findings include the prevalence of ermA, ermB, ermC, mphC, msrA, msrD, mecA, ant(9)-Ia, ant(4′)-Ib, aac(6′)-aph(2″), aph(3′)-III, fosB, tetK, tetM, dfrG, dfrC, and dfrE genes, along with mutations in gyrA and parC contributing to fluoroquinolone resistance.
Antimicrobial Resistance in Coagulase-Negative Staphylococci: Resistome, Mobiloome, and Relatedness
The study identifies multiple AMR genes and mutations in CoNS isolates from various hosts, highlighting the spread of multidrug resistance and the role of mobile genetic elements in the dissemination of resistance traits.
The gut microbiota of wild birds undergoing rehabilitation as a reservoir of multidrug-resistant enterococci in a metropolitan area in Brazil.
The study identified multiple antimicrobial resistance genes in enterococci isolated from wild birds, including genes conferring resistance to aminoglycosides, erythromycin, tetracycline, and streptogramins.
Detection and genetic characterization of multidrug-resistant staphylococci isolated from public areas in an international airport.
The study identified multiple multidrug-resistant staphylococci, including methicillin-resistant S. haemolyticus, S. epidermidis, and a livestock-associated MRSA (LA-MRSA) strain, carrying various resistance genes such as mecA, blaZ, erm(C), aac(6')-aph(2''), and others, highlighting the presence of AMR in public environments.
Zoonotic transmission of asymptomatic carriage Staphylococcus aureus on dairy farms in Canterbury, New Zealand.
The study identified a bovine isolate carrying the extended-spectrum beta-lactamase gene blaTEM-116, highlighting concerns about antimicrobial resistance in dairy farm environments. Multiple antimicrobial resistance genes were detected in both bovine and human isolates, including genes conferring resistance to tetracyclines, penicillins, fosfomycin, and aminoglycosides.
Phylogenomic associations among methicillin-resistant Staphylococcus aureus isolates derived from pets, dairies, and humans.
The study identified several AMR genes in methicillin-resistant Staphylococcus aureus (MRSA) isolates from pets, dairies, and humans, including mecA, tet(M), tet(K), erm(C), erm(A), mph(C), msr(A), blaR1, blaZ, blaI_of_Z, blaPC1, vga(A), fosB-Saur, sat4, bleO, ant(9)-Ia, aph(2'')-Ih, aph(3')-IIIa, and ant(4')-Ia. These genes confer resistance to various antibiotics such as methicillin, tetracycline, erythromycin, macrolides, lincomycin, fosfomycin, streptothricin, bleomycin, spectinomycin, amikacin, gentamicin, kanamycin, tobramycin, and others.
Skin Infections Caused by Panton-Valentine Leukocidin and Methicillin-Susceptible Staphylococcus aureus in Child, Japan.
The study identified the presence of the beta-lactam resistance gene blaZ, the macrolide resistance gene erm(A), and the aminoglycoside resistance gene ant(9)-Ia in the MSSA ST2233 strain causing recurrent skin infections in a child. Additionally, mutations in the GrlA and GyrA genes were detected, contributing to fluoroquinolone resistance.
Study of lug Operon, SCCmec Elements, Antimicrobial Resistance, MGEs, and STs of Staphylococcus lugdunensis Clinical Isolates Through Whole-Genome Sequencing.
The study identified several AMR genes, including mecA, blaZ, erm(A), aac(6')-aph(2"), aph(3')-III, ant(9)-Ia, and dfrG, in S. lugdunensis isolates, which conferred resistance to various antibiotics such as penicillins, oxacillin, erythromycin, clindamycin, aminoglycosides, and trimethoprim-sulfamethoxazole.
Prevalence and antimicrobial resistance of methicillin-resistant and methicillin-susceptible Staphylococcus in small- to medium-scale and large-scale dairy farms in Thailand.
The study identified several AMR genes and mutations in Staphylococcus isolates from small- to medium-scale and large-scale dairy farms in Thailand, highlighting differences in resistance profiles between farm types.
Temporal dynamics of the resistome in gilts raised in an organic operation in which semen used for artificial insemination is the primary source of antimicrobial exposure.
The study identified several tetracycline, aminoglycoside, and MLS resistance genes in the fecal microbiome of gilts, with no significant increases in ARG abundance following exposure to semen extenders containing antibiotics.
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