aph(2'')-G141

aminoglycoside phosphotransferase

Curation StatusNot Validated

Overview

Drug Classes: gentamicin, tobramycin, amikacin, neomycin, netilmicin, kanamycin a, KANAMYCIN, TOBRAMYCIN, GENTAMICIN
Organisms: Enterococcus faecium, Escherichia coli DH5α, E. coli DH10b +5 more
Alleles: 2
Papers: 3

Allele Variants2

Allele	Papers	Drug Classes	Organisms	Countries	Years	Status
aph(2'')-Ib	2	gentamicin, tobramycin +4	Enterococcus faecium +6	Detroit, Mich., Slovakia\|Belgium\|Czech Republic\|France\|Guatemala\|Mexico\|Philippines\|Portugal\|South Africa\|Thailand\|Turkey\|United States\|Venezuela	2000, 2001	Not Validated
APH(2')-G141	2	KANAMYCIN, TOBRAMYCIN +1	Elizabethkingia anophelis	-	2023	Not Validated

Papers3

Detection of the high-level aminoglycoside resistance gene aph(2")-Ib in Enterococcus faecium.

PMID 10991878 · 2000

The study identifies and characterizes the high-level aminoglycoside resistance gene aph(2")-Ib in Enterococcus faecium, which confers resistance to gentamicin.

Gene Information

Gene Name: aph(2'')-G141
Allele: aph(2'')-Ib
Encodes: aminoglycoside phosphotransferase
Validation Method: cloning in E. coli + phosphocellulose paper binding assay

Confers Resistance To

gentamicin

Organisms Tested In

• Enterococcus faecium

• Escherichia coli DH5α

• E. coli DH10b

• E. faecium GE1

• Enterococcus faecalis FA2-2

• E. faecium SF11770

Isolation Details

Country

Detroit, Mich.

Aminoglycoside Resistance Genes aph(2")-Ib and aac(6′)-Im Detected Together in Strains of both Escherichia coli and Enterococcus faecium.

PMID 11557456 · 2001

The study identifies and characterizes the aminoglycoside resistance genes aph(2")-Ib and aac(6′)-Im, which confer resistance to various aminoglycoside antibiotics in both Escherichia coli and Enterococcus faecium.

Gene Information

Gene Name: aph(2'')-G141
Allele: aph(2'')-Ib
Encodes: aminoglycoside phosphotransferase
Validation Method: cloning in E. coli DH5α and MIC testing

Mechanism

phosphorylation of aminoglycosides

Confers Resistance To

gentamicintobramycinamikacinneomycinnetilmicinkanamycin a

Organisms Tested In

• Escherichia coli

• Enterococcus faecium

Isolation Details

Country

Extensive screening reveals previously undiscovered aminoglycoside resistance genes in human pathogens.

PMID 37537271 · 2023

Gene Information

Gene Name: aph(2'')-G141
Allele: APH(2')-G141
Encodes: aminoglycoside O-phosphotransferase APH(2')-G141

Confers Resistance To

KANAMYCINTOBRAMYCINGENTAMICIN

Organisms Tested In

• Elizabethkingia anophelis

Extensive screening reveals previously undiscovered aminoglycoside resistance genes in human pathogens.

PMID 37537271 · 2023

Gene Information

Gene Name: aph(2'')-G141
Allele: APH(2')-G141
Encodes: aminoglycoside O-phosphotransferase APH(2')-G141

Confers Resistance To

KANAMYCINTOBRAMYCINGENTAMICIN

Organisms Tested In

• Elizabethkingia anophelis

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