Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
aminoglycoside 2"-phosphotransferase
Overview
Structural basis for dual nucleotide selectivity of aminoglycoside 2"-phosphotransferase IVa provides insight on determinants of nucleotide specificity of aminoglycoside kinases.
Research Article
The study identifies the structural basis for the dual nucleotide selectivity of aminoglycoside 2"-phosphotransferase IVa (APH(2")-IVa), revealing its ability to utilize both ATP and GTP for phosphorylation of aminoglycoside antibiotics, which contributes to antibiotic resistance.
Capturing the antibiotic resistome of preterm infants reveals new benefits of probiotic supplementation.
Research Article
Probiotic supplementation in preterm infants reduces the diversity and persistence of antibiotic resistance genes in the gut microbiome, particularly targeting aminoglycoside, beta-lactam, tetracycline, and streptogramin resistance genes.
APH Inhibitors that Reverse Aminoglycoside Resistance in Enterococcus casseliflavus.
Research Article
The study identifies EK3 and its derivatives as non-competitive inhibitors of APH(2''''-IVa), an aminoglycoside phosphotransferase that confers resistance to gentamicin in Enterococcus casseliflavus. These inhibitors restore bacterial susceptibility to aminoglycosides.
A new high-level gentamicin resistance gene, aph(2'')-Id, in Enterococcus spp.
Research Article
A new high-level gentamicin resistance gene, aph(2'')-Id, in Enterococcus spp.
Research Article
A new high-level gentamicin resistance gene, aph(2'')-Id, in Enterococcus spp.
Research Article
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