Browse AMR Genes

Gene Information

Gene Name: aph(3'')-Ia
Allele: APH(3'')-Ia
Encodes: aminoglycoside O-phosphotransferase APH(3'')-Ia
Source Database: Reference Gene Catalog
Mechanism: Enzymatic modification
Confers Resistance To: STREPTOMYCIN
Organisms Tested In: • Streptomyces griseus subsp. griseus NBRC 13350
Sequence Accession: AP009493.1
Protein Accession: BAG17078.1
Notes: Chromosomal, Alternative name aphE, aphD2

Conditionally positive effect of the TetR-family transcriptional regulator AtrA on streptomycin production by Streptomyces griseus.

Research Article

Gene Information

Gene Name: aph(3'')-Ia
Allele: APH(3'')-Ia
Encodes: aminoglycoside O-phosphotransferase APH(3'')-Ia
Source Database: ResFinder Database
Mechanism: Enzymatic modification
Confers Resistance To: STREPTOMYCIN
Organisms Tested In: • Streptomyces griseus subsp. griseus NBRC 13350
Sequence Accession: AP009493.1
Protein Accession: BAG17078.1
Notes: Chromosomal, Alternative name aphE, aphD2

PCR cloning of a streptomycin phosphotransferase (aphE) gene from Streptomyces griseus ATCC 12475.

Research Article

Gene Information

Gene Name: aph(3'')-Ia
Allele: APH(3'')-Ia
Encodes: aminoglycoside O-phosphotransferase APH(3'')-Ia
Source Database: Reference Gene Catalog
Mechanism: Enzymatic modification
Confers Resistance To: STREPTOMYCIN
Organisms Tested In: • Streptomyces griseus
Sequence Accession: X53527.1
Protein Accession: CAA37605.1
Notes: Chromosomal, Alternative name aphE, aphD2

PCR cloning of a streptomycin phosphotransferase (aphE) gene from Streptomyces griseus ATCC 12475.

Research Article

Gene Information

Gene Name: aph(3'')-Ia
Allele: APH(3'')-Ia
Encodes: aminoglycoside O-phosphotransferase APH(3'')-Ia
Source Database: ResFinder Database
Mechanism: Enzymatic modification
Confers Resistance To: STREPTOMYCIN
Organisms Tested In: • Streptomyces griseus
Sequence Accession: X53527.1
Protein Accession: CAA37605.1
Notes: Chromosomal, Alternative name aphE, aphD2

PCR cloning of a streptomycin phosphotransferase (aphE) gene from Streptomyces griseus ATCC 12475.

Research Article

PMID 2167474, 18310036, 2844130 · 1990

Gene Information

Gene Name: aph(3'')-Ia
Allele: APH(3'')-Ia
Encodes: aminoglycoside O-phosphotransferase APH(3'')-Ia, APH(3'')
Source Database: Card Database
Mechanism: Enzymatic modification, antibiotic inactivation
Confers Resistance To: STREPTOMYCIN
Organisms Tested In: • Streptomyces griseus
Sequence Accession: X53527.1
Protein Accession: CAA37605.1
Notes: Chromosomal, Alternative name aphE, aphD2, ARO:3002638

PCR cloning of a streptomycin phosphotransferase (aphE) gene from Streptomyces griseus ATCC 12475., Conditionally positive effect of the TetR-family transcriptional regulator AtrA on streptomycin production by Streptomyces griseus., A second streptomycin resistance gene from Streptomyces griseus codes for streptomycin-3"-phosphotransferase. Relationships between antibiotic and protein kinases.

Research Article

Gene Information

Gene Name: aph(3'')-Ia
Allele: aph(3'')-Ia
Source Database: ResFinder Database
Mechanism: Enzymatic modification
Confers Resistance To: STREPTOMYCIN
Organisms Tested In: • Streptomyces griseus, Streptomyces griseus subsp. griseus NBRC 13350
Sequence Accession: X53527, AP009493, M37378
Notes: Chromosomal, Alternative name aphE, aphD2

A second streptomycin resistance gene from Streptomyces griseus codes for streptomycin-3"-phosphotransferase. Relationships between antibiotic and protein kinases.

Research Article

Gene Information

Gene Name: aph(3'')-Ia
Allele: APH(3'')-Ia
Encodes: aminoglycoside O-phosphotransferase APH(3'')-Ia
Source Database: Reference Gene Catalog
Mechanism: Enzymatic modification
Confers Resistance To: STREPTOMYCIN
Organisms Tested In: • Streptomyces griseus
Sequence Accession: M37378.1
Protein Accession: AAA26700.1
Notes: Chromosomal, Alternative name aphE, aphD2

A second streptomycin resistance gene from Streptomyces griseus codes for streptomycin-3"-phosphotransferase. Relationships between antibiotic and protein kinases.

Research Article

Bacterial genomes carrying this gene

Gene Information

Gene Name: aph(3'')-Ia
Allele: APH(3'')-Ia
Encodes: aminoglycoside O-phosphotransferase APH(3'')-Ia
Source Database: ResFinder Database
Mechanism: Enzymatic modification
Confers Resistance To: STREPTOMYCIN
Organisms Tested In: • Streptomyces griseus
Sequence Accession: M37378.1
Protein Accession: AAA26700.1
Notes: Chromosomal, Alternative name aphE, aphD2

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aph(3'')-Ia

View on PubMed

aminoglycoside O-phosphotransferase APH(3'')-Ia

NCBI Pathogen Isolates

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to aph(3'')-Ia

AMR Rules

Browse AMR rules for aph(3'')-Ia

Validation StatusConfirmed2+ DBs

Overview

Mechanism: Enzymatic modification
Drug Classes: STREPTOMYCIN
Organisms: Streptomyces griseus subsp. griseus NBRC 13350, Streptomyces griseus, Streptomyces griseus, Streptomyces griseus subsp. griseus NBRC 13350
Papers: 4
Databases: Card DatabaseReference Gene CatalogResFinder Database

Papers4

Conditionally positive effect of the TetR-family transcriptional regulator AtrA on streptomycin production by Streptomyces griseus.

Research Article

Gene Information

Gene Name: aph(3'')-Ia
Allele: APH(3'')-Ia
Encodes: aminoglycoside O-phosphotransferase APH(3'')-Ia
Source Database: Reference Gene Catalog
Mechanism: Enzymatic modification
Confers Resistance To: STREPTOMYCIN
Organisms Tested In: • Streptomyces griseus subsp. griseus NBRC 13350
Sequence Accession: AP009493.1
Protein Accession: BAG17078.1
Notes: Chromosomal, Alternative name aphE, aphD2

Conditionally positive effect of the TetR-family transcriptional regulator AtrA on streptomycin production by Streptomyces griseus.

Research Article

Gene Information

Gene Name: aph(3'')-Ia
Allele: APH(3'')-Ia
Encodes: aminoglycoside O-phosphotransferase APH(3'')-Ia
Source Database: ResFinder Database
Mechanism: Enzymatic modification
Confers Resistance To: STREPTOMYCIN
Organisms Tested In: • Streptomyces griseus subsp. griseus NBRC 13350
Sequence Accession: AP009493.1
Protein Accession: BAG17078.1
Notes: Chromosomal, Alternative name aphE, aphD2

PCR cloning of a streptomycin phosphotransferase (aphE) gene from Streptomyces griseus ATCC 12475.

Research Article

Gene Information

Gene Name: aph(3'')-Ia
Allele: APH(3'')-Ia
Encodes: aminoglycoside O-phosphotransferase APH(3'')-Ia
Source Database: Reference Gene Catalog
Mechanism: Enzymatic modification
Confers Resistance To: STREPTOMYCIN
Organisms Tested In: • Streptomyces griseus
Sequence Accession: X53527.1
Protein Accession: CAA37605.1
Notes: Chromosomal, Alternative name aphE, aphD2

PCR cloning of a streptomycin phosphotransferase (aphE) gene from Streptomyces griseus ATCC 12475.

Research Article

Gene Information

Gene Name: aph(3'')-Ia
Allele: APH(3'')-Ia
Encodes: aminoglycoside O-phosphotransferase APH(3'')-Ia
Source Database: ResFinder Database
Mechanism: Enzymatic modification
Confers Resistance To: STREPTOMYCIN
Organisms Tested In: • Streptomyces griseus
Sequence Accession: X53527.1
Protein Accession: CAA37605.1
Notes: Chromosomal, Alternative name aphE, aphD2

PCR cloning of a streptomycin phosphotransferase (aphE) gene from Streptomyces griseus ATCC 12475.

Research Article

PMID 2167474, 18310036, 2844130 · 1990

Gene Information

Gene Name: aph(3'')-Ia
Allele: APH(3'')-Ia
Encodes: aminoglycoside O-phosphotransferase APH(3'')-Ia, APH(3'')
Source Database: Card Database
Mechanism: Enzymatic modification, antibiotic inactivation
Confers Resistance To: STREPTOMYCIN
Organisms Tested In: • Streptomyces griseus
Sequence Accession: X53527.1
Protein Accession: CAA37605.1
Notes: Chromosomal, Alternative name aphE, aphD2, ARO:3002638

Research Article

Gene Information

Gene Name: aph(3'')-Ia
Allele: aph(3'')-Ia
Source Database: ResFinder Database
Mechanism: Enzymatic modification
Confers Resistance To: STREPTOMYCIN
Organisms Tested In: • Streptomyces griseus, Streptomyces griseus subsp. griseus NBRC 13350
Sequence Accession: X53527, AP009493, M37378
Notes: Chromosomal, Alternative name aphE, aphD2

A second streptomycin resistance gene from Streptomyces griseus codes for streptomycin-3"-phosphotransferase. Relationships between antibiotic and protein kinases.

Research Article

Gene Information

Gene Name: aph(3'')-Ia
Allele: APH(3'')-Ia
Encodes: aminoglycoside O-phosphotransferase APH(3'')-Ia
Source Database: Reference Gene Catalog
Mechanism: Enzymatic modification
Confers Resistance To: STREPTOMYCIN
Organisms Tested In: • Streptomyces griseus
Sequence Accession: M37378.1
Protein Accession: AAA26700.1
Notes: Chromosomal, Alternative name aphE, aphD2

A second streptomycin resistance gene from Streptomyces griseus codes for streptomycin-3"-phosphotransferase. Relationships between antibiotic and protein kinases.

Research Article