The study identifies and characterizes a novel streptomycin resistance gene, aph(3")-Ic, from Mycobacterium fortuitum, which confers resistance to streptomycin through phosphorylation and inactivation of the antibiotic.

The study reports the draft genome sequence of a multidrug-resistant Morganella morganii isolate carrying the qnrD1 gene, along with various other antibiotic resistance genes such as aadA1y, aph(3')-Ic, strA-strB, blaOXA-1, catA2, catB3, sul2, dfrA1, tetY, and sat2.

The study identified the presence of the aph(3')-Ic, aph(3")-Ib, aph(6)-Id, and aac(3)-XI genes in Corynebacterium striatum clinical isolates, which confer resistance to various aminoglycosides. These genes were detected through PCR and sequencing, and their association with resistance was confirmed by MIC testing.

The study identifies multiple carbapenemase genes (bla KPC-2, bla KPC-3, bla KPC-4, and bla NDM-1) and other resistance genes (such as qnrB19, qnrB2, qnrS1, bla TEM-1A, bla TEM-1B, bla OXA-9, bla SHV-12, aadA2, aac(6')-Ib, aac(6')-Ib-cr, aph(3')-Ia, aph(3')-Ic, strA, strB, sul1, sul2, dfrA14, dfrA18, mph(A), catB3, arr-3, and tet(D)) in carbapenem-resistant Enterobacter spp. These genes are primarily located on plasmids and contribute to multidrug resistance.

The study identifies carbapenem-resistant Acinetobacter indicus-like isolates from cattle carrying the blaOXA-23 gene, along with various other AMR genes such as aac(3)-IIa, strA/B, aph(3')-Ic, sul2, floR, tet(A), tet(Y), aadA1, aadB, sul1, and tet(X).

The study identified multiple antimicrobial resistance genes in the multidrug-resistant, heat-resistant E. coli strain FAM21845, including beta-lactamase blaTEM-1, aminoglycoside resistance genes strA, strB, aadA1, aph(3')-Ic, aph(4)-Ia, aac(3)-IVa, sulfonamide resistance gene sul1, trimethoprim resistance gene dfrA1, tetracycline resistance gene tet(B), disinfectant resistance gene qacEΔ1, and biofilm-related genes mrkABCDF. Additionally, the strain carried genes for resistance to arsenic, silver, and copper.

The study identifies several AMR genes and mutations in Corynebacterium striatum, including bla, erm(X), erm(B), aph(3')-Ic, aac(3)-XI, aph(3'')-Ib, and aph(6)-Id, along with gyrA mutations contributing to fluoroquinolone resistance.

The study characterized various AMR genes in Acinetobacter spp. including blaPER-1, blaTEM-1D, blaADC-31, blaOXA-82, aac(3')-Ia, aac(6')-Il, aph(3')-Ic, strAB, and others. Mutations in gyrA and parC were associated with fluoroquinolone resistance. Overexpression of efflux pumps like adeB and adeJ contributed to multidrug resistance.

The study identifies several AMR genes in multidrug-resistant Gram-negative bacteria isolated from German surface waters, highlighting the presence of clinically relevant resistance mechanisms such as bla CTX-M-1, bla CTX-M-15, mcr-1, and others.

The study identifies the disruption of lpxA, mlaD, and pldA genes by IS Ajo2 and IS Aba13 insertions in colistin-dependent A. baumannii, leading to lipid A deficiency and colistin dependence.

The study identifies various ESBL and AmpC beta-lactamase genes, including bla SHV-12, bla CTX-M-1, bla CTX-M-2, bla CTX-M-14, bla CTX-M-15, bla TEM-52, and bla CMY-2, along with the mcr-1 gene conferring colistin resistance in E. coli isolates from food animals in Europe.

The study identified bla OXA-23 as the primary cause of carbapenem resistance in Acinetobacter baumannii isolates from Afghanistan, along with various other resistance genes for sulfonamides, macrolides, tetracyclines, and aminoglycosides.

The study identified bla OXA-23 as the primary cause of carbapenem resistance in Acinetobacter baumannii isolates from Afghanistan, along with various other resistance genes for sulfonamides, macrolides, tetracyclines, and aminoglycosides.

The study identified an intrinsic resistome in Mycolicibacterium fortuitum comprising genes such as aph(3''-Ic), aac(2')-Ib, arr, blaF, erm39, rbpA, rox, and tap, which confer resistance to various antibiotics including macrolides, aminoglycosides, carbapenems, cephalosporins, and rifampicin. Additionally, a class 1 integron carrying qac/sul1 gene cassette was detected in one genome.

Early-life broad-spectrum antibiotics alter the infant gut microbiome and resistome, with amoxicillin + cefotaxime having the most significant impact on AMR gene profiles.

The study identifies multiple antimicrobial resistance genes (ARGs) in highly drug-resistant Escherichia coli isolates from veal calves, including blaCMY-2, blaCTX-M-15, mph(A), erm(B), aac(6')-Ib-cr, qnrS1, aadA5, aadA1, aph(3')-Ic, aph(3')-Ia, aph(3')-Ib, aph(6')-Id, sul1, sul2, tet(A), and tet(B). Additionally, mutations in gyrA (S83L, D87N) and parC (A56T) were found to contribute to fluoroquinolone resistance.

The study identified multiple AMR genes in equine Acinetobacter baumannii isolates, including beta-lactamases (bla OXA-51-like, bla ADC-25, bla TEM-1D), sulfonamide resistance genes (sul1, sul2), chloramphenicol resistance genes (catA1, ABUW 0982), tetracycline resistance genes (tet(A), tet(B), tet(39)), and aminoglycoside modifying enzymes (aph(3′)-Ia, aph(3`)-Ic, aph(6)-Id, aac(3)-Ia). Additionally, eight novel OXA-51-like variants (OXA-970 to OXA-977) were characterized.

The study identified VIM-1, AAC(6')-Ib, APH(3')-Ia, ANT(3'')-Ia, Sul1, and DfrA1 as genes with significant differential abundance in a carbapenem-resistant K. pneumoniae strain exposed to sublethal concentrations of ertapenem, indicating their roles in antibiotic resistance.