Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
phosphotransferase
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| APH(3')-IIb | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 44 | Aminoglycoside, Gentamicin +13 |
| Australia|India, India, Indonesia, Germany, Italy, Stockholm|Sweden, Saudi Arabia, Hungary, Ghana, Spain|Portugal, Iran, Japan, Qatar, China, Thailand, France, Egypt, Singapore, Southern California, USA, UK, Netherlands|Kenya|United States|India|Tanzania, Bulgaria, East Africa, South India, UK|Kuwait, Western Balkans|Hungary |
| 1996, 2010, 2018, 2019, 2020, 2021, 2022, 2023, 2024, 2025 |
| CP030125|CP030126|CP020560.1|CP020561.2 |
| CAA62365.1 |
| aph(3')Iib | Reslit | 1 | Aminoglycoside | Pseudomonas aeruginosa | India | 2015 | JAAO00000000.1 | - |
| Aph3-IIb | Reslit | 1 | Aminoglycoside | Pseudomonas aeruginosa | - | 2021 | - | - |
| aph3-Iib | Reslit | 1 | Aminoglycoside | Pseudomonas aeruginosa | Northwestern Tunisia|Tunisia | 2021 | WP_003118452.1|AQA26426.1 | - |
| aph (3′)-IIb | Reslit | 1 | Aminoglycoside | Pseudomonas aeruginosa | Pakistan | 2021 | JADDMB000000000|JADDMA000000000|JADEYD000000000|JADDLZ000000000|JADDLY000000000|JADDLX000000000|PRJNA669539|PRJNA670459 | - |
| aph(3')-IIb | ResFinder Database | 1 | RIBOSTAMYCIN, BUTIROMYCIN +4 | Pseudomonas aeruginosa, Pseudomonas aeruginosa PAO1-VE13 | - | 1996 | X90856, CP006832 | - |
Aminoglycoside modifying enzymes.
The paper discusses various aminoglycoside modifying enzymes, particularly focusing on AAC(6')-Ib, AAC(6')-Ib-cr, and AAC(6')-Ib 11, which confer resistance to aminoglycosides like amikacin and gentamicin, and in some cases, quinolones.
Draft genome sequence of blaVeb-1, blaoxa-10 producing multi-drug resistant (MDR) Pseudomonas aeruginosa strain VRFPA09 recovered from bloodstream infection.
The study reports the draft genome sequence of MDR Pseudomonas aeruginosa strain VRFPA09, identifying several AMR genes including blaVeb-1, blaOXA-10, aadA1, aph(3')Iib, Sul1, CatB7, TetG, dfrB5, and fosA, which contribute to resistance against various antibiotics.
Comparative genomics of clinical strains of Pseudomonas aeruginosa strains isolated from different geographic sites.
The study identified several AMR genes in Pseudomonas aeruginosa strains from different geographic locations, including beta-lactamases, aminoglycoside resistance genes, fosfomycin resistance, chloramphenicol resistance, sulfonamide resistance, quaternary ammonium compound resistance, tetracycline resistance, and others. Indian eye isolates exhibited a higher diversity of resistance genes compared to Australian isolates.
Comparative Genomic Analyses Reveal Core-Genome-Wide Genes Under Positive Selection and Major Regulatory Hubs in Outlier Strains of Pseudomonas aeruginosa.
The study identified genes under positive selection in Pseudomonas aeruginosa outlier strains, including oprD, which is implicated in carbapenem resistance through reduced uptake.
High-Risk International Clones of Carbapenem-Nonsusceptible Pseudomonas aeruginosa Endemic to Indonesian Intensive Care Units: Impact of a Multifaceted Infection Control Intervention Analyzed at the Genomic Level.
The study identified several carbapenemase-encoding genes (blaGES-5, blaIMP-1, blaIMP-7, blaIMP-43, blaVIM-2, and blaVIM-8) and mutations in the porin gene oprD that contribute to carbapenem resistance in Pseudomonas aeruginosa isolates from Indonesian ICUs.
Multidrug-Resistant and Clinically Relevant Gram-Negative Bacteria Are Present in German Surface Waters.
The study identifies several AMR genes in multidrug-resistant Gram-negative bacteria isolated from German surface waters, highlighting the presence of clinically relevant resistance mechanisms such as bla CTX-M-1, bla CTX-M-15, mcr-1, and others.
First detection of autochthonous extensively drug-resistant NDM-1 Pseudomonas aeruginosa ST235 from a patient with bloodstream infection in Italy, October 2019.
The study reports the first autochthonous extensively drug-resistant NDM-1 Pseudomonas aeruginosa ST235 strain in Italy, highlighting the presence of multiple beta-lactamase genes, aminoglycoside modifying enzymes, and multidrug efflux pumps contributing to its extensive drug resistance.
First detection of autochthonous extensively drug-resistant NDM-1 Pseudomonas aeruginosa ST235 from a patient with bloodstream infection in Italy, October 2019.
The study reports the first autochthonous extensively drug-resistant NDM-1 Pseudomonas aeruginosa ST235 strain in Italy, highlighting the presence of multiple beta-lactamase genes, aminoglycoside modifying enzymes, and multidrug efflux pumps contributing to its extensive drug resistance.
Revealing antimicrobial resistance in stormwater with MinION.
The study identified several AMR genes in stormwater samples from Stockholm, including aac(3)-X, aac(6')-I, aph(3')-I, aph(3')-IIb, bacA, chloramphenicol, rosA, ermO, abeS, major facilitator superfamily transporter, mexE, mexX, ompR, opcM, oprA, oprN, qacG, puromycin, ADP-ribosylating, dfrA12, vanH, vanR, and vanS, which confer resistance to various antibiotics such as aminoglycosides, beta-lactams, chloramphenicol, fosmidomycin, MLS, multidrug, puromycin, rifamycin, trimethoprim, and vancomycin.
Whole Genome Sequencing of Ceftolozane-Tazobactam and Ceftazidime-Avibactam Resistant Pseudomonas aeruginosa Isolated from a Blood Stream Infection Reveals VEB and Chromosomal Metallo-Beta Lactamases as Genetic Determinants: A Case Report.
The study identifies multiple AMR genes in a multidrug-resistant Pseudomonas aeruginosa strain, including beta-lactamases (blaVEB-9, blaOXA-10, blaOXA-50, blaPDC-11), aminoglycoside resistance genes (aph(3')-IIb, aac(6')-Il, ant(2'')-Ia), fluoroquinolone resistance gene (crpP), phenicol resistance gene (catB7), and tetracycline resistance gene (tet(A)).
A glimpse of antimicrobial resistance gene diversity in kefir and yoghurt.
The study identified several antimicrobial resistance genes (ARGs) in kefir and yoghurt samples, including lmrD, poxtA, and APH(3')-IIb, which confer resistance to various antibiotics such as lincosamides, macrolides, oxazolidinones, phenicols, pleuromutilins, streptogramins, tetracyclines, and aminoglycosides.
Full pathogen characterisation: species identification including the detection of virulence factors and antibiotic resistance genes via multiplex DNA-assays.
The study presents a DNA microarray-based assay for the simultaneous detection of 44 sepsis-relevant bacterial pathogens, 360 virulence factors, and 409 antibiotic resistance genes. The assay was evaluated with 14 multidrug-resistant strains, including all ESKAPE pathogens.
Clonal Clusters, Molecular Resistance Mechanisms and Virulence Factors of Gram-Negative Bacteria Isolated from Chronic Wounds in Ghana.
The study identified various AMR genes and mutations in Gram-negative bacteria isolated from chronic wounds in Ghana, including beta-lactamases, fosfomycin resistance genes, chloramphenicol resistance genes, aminoglycoside resistance genes, fluoroquinolone resistance genes, tetracycline resistance genes, sulfonamide resistance genes, trimethoprim resistance genes, and efflux pumps. Mutations in gyrA, parE, and parC were also found to contribute to fluoroquinolone resistance.
Persistent Bacterial Coinfection of a COVID-19 Patient Caused by a Genetically Adapted Pseudomonas aeruginosa Chronic Colonizer.
The study identifies several antimicrobial resistance genes in a genetically adapted Pseudomonas aeruginosa isolate from a COVID-19 patient, including aph(3')-IIb, blaOXA-395, blaPAO, fosA, and catB7, which confer resistance to aminoglycosides, beta-lactams, fosfomycin, and phenicols.
Characterization of Antimicrobial Resistance Mechanisms in Clinical Isolates of Pseudomonas aeruginosa from a Cystic Fibrosis Patient
The study identified various AMR genes and mutations in P. aeruginosa isolates from a CF patient, including beta-lactamases, aminoglycoside-modifying enzymes, fluoroquinolone resistance genes, and mutations in regulatory and structural genes contributing to resistance against multiple antibiotics.
Role of Aminoglycoside-Modifying Enzymes (AMEs) in Resistance to Aminoglycosides among Clinical Isolates of Pseudomonas aeruginosa in the North of Iran.
The study identified several aminoglycoside-modifying enzyme-encoding genes, including AAC(6')-Ib, AAC(6')-IIa, APH(3')-IIb, ANT(3'')-Ia, and ANT(2'')-Ia, which are associated with resistance to aminoglycosides in Pseudomonas aeruginosa isolates from the north of Iran.
Occurrence of NDM-1 and VIM-2 Co-Producing Escherichia coli and OprD Alteration in Pseudomonas aeruginosa Isolated from Hospital Environment Samples in Northwestern Tunisia.
The study identifies NDM-1 and VIM-2 co-producing E. coli and OprD alterations in P. aeruginosa, highlighting the emergence of multidrug-resistant Gram-negative bacteria in hospital environments in Tunisia.
Antimicrobial Resistance and Type III Secretion System Virulotypes of Pseudomonas aeruginosa Isolates from Dogs and Cats in Primary Veterinary Hospitals in Japan: Identification of the International High-Risk Clone Sequence Type 235.
The study identifies various AMR genes and mutations in P. aeruginosa isolates from dogs and cats in Japan, highlighting the presence of high-risk clones like ST235 and the role of genetic factors in carbapenem and fluoroquinolone resistance.
Antimicrobial Resistance and Genomic Characterization of Six New Sequence Types in Multidrug-Resistant Pseudomonas aeruginosa Clinical Isolates from Pakistan.
The study identified 13 acquired antibiotic resistance genes in six new sequence types of multidrug-resistant Pseudomonas aeruginosa isolates from Pakistan, including beta-lactamases, aminoglycoside-modifying enzymes, and others. Mutations in the pmrA gene were also found to contribute to colistin resistance.
Clinical outcomes, molecular epidemiology and resistance mechanisms of multidrug-resistant Pseudomonas aeruginosa isolated from bloodstream infections from Qatar.
The study identified several AMR genes and mutations in MDR P. aeruginosa isolates from Qatar, including blaVIM, blaOXA-50, aac(6')-Ib, aadA, ant(2')-Ia, aph(3')-IIb, qnrS1, crpP, gyrA(T83I), parC(S83I), parE(A473V), pbp3(D350N, S357N), and ompK37(M70I, M128I). These resistance mechanisms contribute to the multidrug-resistant phenotype observed in the isolates.
Genomic heterogeneity underlies multidrug resistance in Pseudomonas aeruginosa: A population-level analysis beyond susceptibility testing.
Identification of a Multidrug Resistant Pseudomonas aeruginosa Isolate Harboring Infrequent Red Fluorescence Plasmid from COPD Patient.
The study identifies a multidrug-resistant Pseudomonas aeruginosa isolate L1a harboring an infrequent red fluorescence plasmid. The isolate shows resistance to several antibiotics including levofloxacin, cefepime, aztreonam, and imipenem, and carries multiple drug resistance genes and efflux pump-related genes.
Antimicrobial Susceptibility and Molecular Features of Colonizing Isolates of Pseudomonas aeruginosa and the Report of a Novel Sequence Type (ST) 3910 from Thailand.
The study identified several antimicrobial resistance genes in Pseudomonas aeruginosa colonizing isolates, including bla OXA-50, aph(3′)-IIb, fosA, bla PAO, catB7, and crpP, which confer resistance to beta-lactam, aminoglycoside, fosfomycin, chloramphenicol, and ciprofloxacin. A novel sequence type ST-3910 was also reported.
Antimicrobial Resistance and Genetic Diversity of Pseudomonas aeruginosa Strains Isolated from Equine and Other Veterinary Samples.
The study identified several AMR genes in Pseudomonas aeruginosa strains isolated from equine and other veterinary samples, including beta-lactamases, aminoglycoside modifying enzymes, quinolone resistance genes, sulfonamide resistance genes, phenicol resistance genes, tetracycline resistance genes, and efflux pumps. Additionally, genes conferring resistance to quaternary ammonium compounds were detected.
Genome Analysis of Pseudomonas aeruginosa Strains from Chronically Infected Patients with High Levels of Persister Formation.
The study identified multiple AMR genes and efflux pump systems in P. aeruginosa persister isolates, highlighting their multidrug-resistant phenotype and biofilm-forming capabilities.
Dissemination of Pseudomonas aeruginosa bla(NDM-1)-Positive ST308 Clone in Singapore.
The study identifies multiple antibiotic resistance genes (ARGs) in bla NDM-1 -positive P. aeruginosa ST308 isolates, including aac(3)-Id, aac(6′)-Il, aph(3′)-Iib, bla OXA-488, bla NDM-1, bla PDC-19a, catB7, crpP, fosA, msr(E), qnrVC1, sul2, dfrB5, floR, aadA6, aadA11, and aph(3″)-Ib. These genes confer resistance to various antibiotics such as aminoglycosides, beta-lactams, carbapenems, cephalosporins, chloramphenicol, fluoroquinolones, fosfomycin, macrolides, quinolones, sulfonamides, trimethoprim, and streptomycin.
Involvement of Acquired Tobramycin Resistance in the Shift to the Viable but Non-Culturable State in Pseudomonas aeruginosa.
The study identifies the role of acquired tobramycin resistance mechanisms, including the ant(2")-Ia, aph(3')-IIb, aac(6')-Ib3 genes, and the mexY gene encoding the MexXY-OprM efflux pump, in the transition of Pseudomonas aeruginosa to the viable but non-culturable (VBNC) state.
Domestically Acquired NDM-1-Producing Pseudomonas aeruginosa, Southern California, USA, 2023
The study reports a case of domestically acquired NDM-1-producing Pseudomonas aeruginosa in a transplant patient in southern California, highlighting the presence of multiple resistance genes including blaNDM-1, blaOXA-10, blaOXA-488, blaPDC-35, blaPME-1, aac(6')-Ib9, ant(3”)-IIa, aph(3′)-IIb, aph(3′)-VIa, catB3, catB7, cmlA9, fosA, tet(D), and sul1.
Phenotypic and genomic characterization of Pseudomonas aeruginosa isolates recovered from catheter-associated urinary tract infections in an Egyptian hospital.
The study identified multiple AMR genes and mutations in Pseudomonas aeruginosa isolates from catheter-associated urinary tract infections in Egypt, including beta-lactamases, aminoglycoside-modifying enzymes, quinolone resistance proteins, and efflux pump systems. Additionally, a pBT2436-like megaplasmid was detected, which contributes to multidrug resistance.
Antibiotic resistance, bacterial transmission and improved prediction of bacterial infection in patients with antibody deficiency.
The study identifies high levels of antibiotic resistance in respiratory tract bacteria from patients with antibody deficiency, particularly macrolide resistance genes erm(B) and mef(A), and highlights the role of commensal streptococci as reservoirs for resistance genes.
Short-duration selective decontamination of the digestive tract infection control does not contribute to increased antimicrobial resistance burden in a pilot cluster randomised trial (the ARCTIC Study).
The study found no significant increase in clinically relevant antimicrobial resistance gene burden in critically ill children treated with SDD-enhanced infection control compared to standard care.
Tracing the origin of NDM-1-producing and extensively drug-resistant Pseudomonas aeruginosa ST357 in the Netherlands.
The study identifies the NDM-1-producing Pseudomonas aeruginosa ST357 as an extensively drug-resistant strain with a unique resistome, highlighting the importance of tracking the origin of such isolates through genomic epidemiology.
Metrological evaluation of DNA extraction method effects on the bacterial microbiome and resistome in sputum.
The study evaluated the impact of DNA extraction methods on the detection of the bacterial microbiome and resistome in sputum samples using targeted high-throughput sequencing. It identified several AMR genes, including eptA, uppP, macB, aph(3') iib, and catB7, which were detected in spiked sputum samples.
Genomic Insights into Vietnamese Extended-Spectrum β-Lactamase-9-Producing Extensively Drug-Resistant Pseudomonas aeruginosa Isolates Belonging to the High-Risk Clone ST357 Obtained from Bulgarian Intensive Care Unit Patients.
The study identified multiple AMR genes, including blaVEB-9, blaPDC-3, blaOXA-10, blaOXA-50, and others, in two extensively drug-resistant Pseudomonas aeruginosa isolates from Bulgaria. These genes conferred resistance to various antibiotics, including β-lactams, aminoglycosides, and fluoroquinolones.
Metagenome mining divulges virulent and multidrug resistant Pseudomonas aeruginosa ST242 and Klebsiella michiganensis ST∗1b23 coinfecting an 8-month-old meningitis infant under ICU in Kampala, Uganda, East Africa.
The study identified four acquired AMR genes (aph(3')-Ia, blaOXY-1, OqxA, and OqxB) and mutations in OmpK35 and OmpK36 associated with cephalosporin and carbapenem resistance in K. michiganensis RSM9152B-2.
Antimicrobial Resistance in Wastewater Samples from Kumasi, Ghana: A Genomic and Metagenomic Analysis
The study identified several AMR genes and mutations in P. aeruginosa and K. pneumoniae isolates from wastewater samples in Kumasi, Ghana, highlighting the presence of multidrug-resistant strains carrying genes such as blaCTX-M-15, blaOXA-488, and qnrVC1, along with mutations in gyrA and parC contributing to fluoroquinolone resistance.
Essential oils modulate virulence phenotypes in a multidrug-resistant pyomelanogenic Pseudomonas aeruginosa clinical isolate.
The study identifies multiple AMR genes in the MDR P. aeruginosa strain U804, including beta-lactamases, aminoglycoside modifying enzymes, and efflux pumps, which contribute to its resistance against various antibiotics.
Essential oils modulate virulence phenotypes in a multidrug-resistant pyomelanogenic Pseudomonas aeruginosa clinical isolate.
The study identifies multiple AMR genes in the MDR P. aeruginosa strain U804, including beta-lactamases, aminoglycoside modifying enzymes, and efflux pumps, which contribute to its resistance against various antibiotics.
Genotypic and phenotypic analyses of two distinct sets of Pseudomonas aeruginosa urinary tract isolates.
The study identified multiple AMR genes and mutations in P. aeruginosa UTI isolates from the UK and Kuwait, highlighting the presence of multidrug-resistant strains, especially in Kuwaiti isolates. Key AMR genes included aac(3)-IV, aph(3')-Ib, aph(3')-IIb, aph(4)-Ia, aph(6)-Id, crpP, dfrB1, aac(6')-Ib7, aac(6')-ii, aaA61, blaPDC, and blaVIM-28. Mutations in gyrA were also found to contribute to fluoroquinolone resistance.
In-depth genome and comparative genome analysis of a metal-resistant environmental isolate Pseudomonas aeruginosa S-8.
The study identified several antibiotic resistance genes in Pseudomonas aeruginosa S-8, including beta-lactamases (ampC, blaTEM, blaSHV, blaCTX-M), efflux pump components (mexB, mexA, oprM, acrB, tolC), and a transcriptional regulator (ampR). These genes contribute to resistance against various antibiotics such as beta-lactams, tetracycline, chloramphenicol, and fluoroquinolones.
Acquired antibiotic resistance of Pseudomonas spp., Escherichia coli and Acinetobacter spp. in the Western Balkans and Hungary with a One Health outlook.
The study identifies various acquired antibiotic resistance genes in Pseudomonas spp., Escherichia coli, and Acinetobacter spp. in the Western Balkans and Hungary, including beta-lactamases like bla VIM-2-like, bla NDM-1, bla OXA-23, and bla OXA-66, aminoglycoside resistance genes such as aacA4, aadA2, and aphA, sulfonamide resistance gene sul1, and others. These genes confer resistance to multiple antibiotics, highlighting the complexity of antimicrobial resistance in the region.
The genomic configurations driving antimicrobial resistance and virulence in colistin resistant Pseudomonas aeruginosa from an Egyptian Tertiary Oncology Hospital.
The study identified several AMR genes and mutations in colistin-resistant P. aeruginosa isolates, including blaNDM-1, blaOXA-1028, blaOXA-904, and mutations in phoQ and basR genes associated with colistin resistance.
Genomic characterization and multidrug resistance of Pseudomonas aeruginosa isolated from peregrine falcons in Saudi Arabia: A One Health perspective.
The study identified five AMR genes in a multidrug-resistant Pseudomonas aeruginosa isolate from peregrine falcons in Saudi Arabia, highlighting the zoonotic potential and the need for integrated AMR surveillance.
Sequence and characterization of a novel chromosomal aminoglycoside phosphotransferase gene, aph (3')-IIb, in Pseudomonas aeruginosa.
Sequence and characterization of a novel chromosomal aminoglycoside phosphotransferase gene, aph (3')-IIb, in Pseudomonas aeruginosa.
Sequence and characterization of a novel chromosomal aminoglycoside phosphotransferase gene, aph (3')-IIb, in Pseudomonas aeruginosa.
Sequence and characterization of a novel chromosomal aminoglycoside phosphotransferase gene, aph (3')-IIb, in Pseudomonas aeruginosa., Draft Genome Sequences of Two Alginate-Overproducing Variants of Pseudomonas aeruginosa, PAO1-VE2 and PAO1-VE13.
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