Browse AMR Genes

Explore antimicrobial resistance genes from the literature

ResLit

aph(3')-IVa

phosphotransferase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to aph(3')-IVa

AMR Rules

Browse AMR rules for aph(3')-IVa

Validation StatusConfirmed2+ DBs

Overview

Mechanism: Enzymatic modification
Validation Method: genetic analysis
Drug Classes: Aminoglycoside, BUTIROSIN, RIBOSTAMYCIN, PAROMOMYCIN, NEOMYCIN, KANAMYCIN
Organisms: Enterobacteriaceae, Niallia circulans, Riemerella anatipestifer
Geographic Location: China
Alleles: 2
Papers: 3
Databases: Card DatabaseReference Gene CatalogResFinder DatabaseReslit

Allele Variants2

Allele	Database	Papers	Drug Classes	Organisms	Countries	Years	Sequence Accession	Protein Accession
APH(3')-IVa	Card DatabaseReference Gene CatalogResFinder DatabaseReslit	4	Aminoglycoside, BUTIROSIN +4	Enterobacteriaceae +1	-	1986, 2010

Papers3

Aminoglycoside modifying enzymes.

PMID 20833577 · 2010

The paper discusses various aminoglycoside modifying enzymes, particularly focusing on AAC(6')-Ib, AAC(6')-Ib-cr, and AAC(6')-Ib 11, which confer resistance to aminoglycosides like amikacin and gentamicin, and in some cases, quinolones.

Gene Information

Gene Name: aph(3')-IVa
Allele: APH(3')-IVa
Encodes: phosphotransferase
Source Database: Reslit
Confers Resistance To: Aminoglycoside
Organisms Tested In: • Enterobacteriaceae
Validation Method: genetic analysis

Sequence and interspecies transfer of an aminoglycoside phosphotransferase gene (APH) of Bacillus circulans. Self-defence mechanism in antibiotic-producing organisms.

PMID 3006668 · 1986

Gene Information

Gene Name: aph(3')-IVa
Allele: APH(3')-IVa
Encodes: aminoglycoside O-phosphotransferase APH(3')-IVa
Source Database: Reference Gene Catalog
Mechanism: Enzymatic modification
Confers Resistance To: BUTIROSINRIBOSTAMYCINPAROMOMYCINNEOMYCINKANAMYCIN
Organisms Tested In: • Niallia circulans
Sequence Accession: X03364.1
Protein Accession: CAA27061.1
Notes: ARO:3002648

Sequence and interspecies transfer of an aminoglycoside phosphotransferase gene (APH) of Bacillus circulans. Self-defence mechanism in antibiotic-producing organisms.

PMID 3006668 · 1986

Gene Information

Gene Name: aph(3')-IVa
Allele: APH(3')-IVa
Encodes: aminoglycoside O-phosphotransferase APH(3')-IVa
Source Database: ResFinder Database
Mechanism: Enzymatic modification
Confers Resistance To: BUTIROSINRIBOSTAMYCINPAROMOMYCINNEOMYCINKANAMYCIN
Organisms Tested In: • Niallia circulans
Sequence Accession: X03364.1
Protein Accession: CAA27061.1
Notes: ARO:3002648

Sequence and interspecies transfer of an aminoglycoside phosphotransferase gene (APH) of Bacillus circulans. Self-defence mechanism in antibiotic-producing organisms.

PMID 3006668 · 1986

Gene Information

Gene Name: aph(3')-IVa
Allele: APH(3')-IVa
Encodes: aminoglycoside O-phosphotransferase APH(3')-IVa, APH(3')
Source Database: Card Database
Mechanism: Enzymatic modification, antibiotic inactivation
Confers Resistance To: BUTIROSINRIBOSTAMYCINPAROMOMYCINNEOMYCINKANAMYCIN
Organisms Tested In: • Niallia circulans
Sequence Accession: X03364.1
Protein Accession: CAA27061.1
Notes: ARO:3002648

Sequence and interspecies transfer of an aminoglycoside phosphotransferase gene (APH) of Bacillus circulans. Self-defence mechanism in antibiotic-producing organisms.

PMID 3006668 · 1986

Gene Information

Gene Name: aph(3')-IVa
Allele: aph(3')-IV
Source Database: ResFinder Database
Mechanism: Enzymatic modification
Confers Resistance To: BUTIROSINRIBOSTAMYCINPAROMOMYCINNEOMYCINKANAMYCIN
Organisms Tested In: • Niallia circulans
Sequence Accession: X03364

Unveiling the silent threat: A comprehensive review of Riemerella anatipestifer - From pathogenesis to drug resistance.

PMID 40020410 · 2025

This review highlights the pathogenesis, virulence factors, and antibiotic resistance genes of Riemerella anatipestifer, emphasizing its significance in poultry farming and the need for further research on its resistance mechanisms.

Gene Information

Gene Name: aph(3')-IVa
Allele: aph(3')-IV
Encodes: aminoglycoside phosphotransferase
Source Database: Reslit
Mechanism: modifies aminoglycoside antibiotics, leading to their deactivation
Confers Resistance To: Aminoglycoside
Organisms Tested In: • Riemerella anatipestifer
Geographic Location: China
Validation Method: experimental validation