aph(3')-Ia

aminoglycoside phosphotransferase

Curation StatusNot Validated

Overview

Drug Classes: kanamycin, RIBOSTAMYCIN, LIVIDOMYCIN, PAROMOMYCIN, NEOMYCIN, KANAMYCIN, UNKNOWN AMINOGLYCOSIDE
Organisms: Salmonella enterica serovar Choleraesuis, Klebsiella pneumoniae, Avibacterium paragallinarum +7 more
Alleles: 2
Papers: 8

Allele Variants2

Allele	Papers	Drug Classes	Organisms	Countries	Years	Status
aph	1	kanamycin	Salmonella enterica serovar Choleraesuis	Europe	2005	Not Validated
APH(3')-Ia	46	RIBOSTAMYCIN, LIVIDOMYCIN +4	Klebsiella pneumoniae +8	-	1981, 1987, 1991, 2007, 2009, 2011	Not Validated

Papers8

The genome sequence of Salmonella enterica serovar Choleraesuis, a highly invasive and resistant zoonotic pathogen.

PMID 15781495 · 2005

The study identifies multiple antimicrobial resistance genes on plasmids pSC138 and pSCV50 in Salmonella enterica serovar Choleraesuis SC-B67, including blaTEM-1, blaCMY-2, tetRA, strA, aadA2, sulI, sulII, catI, cmlA, aph, sat, mef, mer, ebr, qac, and blaTEM-67. Additionally, mutations in the chromosomal genes gyrA and parC, along with the inactivation of acrR, contribute to ciprofloxacin resistance.

Gene Information

Gene Name: aph(3')-Ia
Allele: aph
Encodes: aminoglycoside phosphotransferase
Validation Method: plasmid analysis

Confers Resistance To

kanamycin

Organisms Tested In

• Salmonella enterica serovar Choleraesuis

Isolation Details

Country

Europe

Evolved neomycin phosphotransferase from an isolate of Klebsiella pneumoniae.

PMID 1662755 · 1991

Gene Information

Gene Name: aph(3')-Ia
Allele: APH(3')-Ia
Encodes: aminoglycoside O-phosphotransferase APH(3')-Ia

Mechanism

Enzymatic modification

Confers Resistance To

RIBOSTAMYCINLIVIDOMYCINPAROMOMYCINNEOMYCINKANAMYCIN

Organisms Tested In

• Klebsiella pneumoniae

Evolved neomycin phosphotransferase from an isolate of Klebsiella pneumoniae.

PMID 1662755 · 1991

Gene Information

Gene Name: aph(3')-Ia
Allele: APH(3')-Ia
Encodes: aminoglycoside O-phosphotransferase APH(3')-Ia

Mechanism

Enzymatic modification

Confers Resistance To

RIBOSTAMYCINLIVIDOMYCINPAROMOMYCINNEOMYCINKANAMYCIN

Organisms Tested In

• Klebsiella pneumoniae

Evolved neomycin phosphotransferase from an isolate of Klebsiella pneumoniae.

PMID 1662755 · 1991

Gene Information

Gene Name: aph(3')-Ia
Allele: APH(3')-Ia
Encodes: aminoglycoside O-phosphotransferase APH(3')-Ia

Mechanism

Enzymatic modification

Confers Resistance To

RIBOSTAMYCINLIVIDOMYCINPAROMOMYCINNEOMYCINKANAMYCIN

Organisms Tested In

• Klebsiella pneumoniae

Evolved neomycin phosphotransferase from an isolate of Klebsiella pneumoniae.

PMID 1662755 · 1991

Gene Information

Gene Name: aph(3')-Ia
Allele: APH(3')-Ia
Encodes: aminoglycoside O-phosphotransferase APH(3')-Ia

Mechanism

Enzymatic modification

Confers Resistance To

RIBOSTAMYCINLIVIDOMYCINPAROMOMYCINNEOMYCINKANAMYCIN

Organisms Tested In

• Klebsiella pneumoniae

Evolved neomycin phosphotransferase from an isolate of Klebsiella pneumoniae.

PMID 1662755 · 1991

Gene Information

Gene Name: aph(3')-Ia
Allele: APH(3')-Ia
Encodes: aminoglycoside O-phosphotransferase APH(3')-Ia

Mechanism

Enzymatic modification

Confers Resistance To

RIBOSTAMYCINLIVIDOMYCINPAROMOMYCINNEOMYCINKANAMYCIN

Organisms Tested In

• Klebsiella pneumoniae

Evolved neomycin phosphotransferase from an isolate of Klebsiella pneumoniae.

PMID 1662755 · 1991

Gene Information

Gene Name: aph(3')-Ia
Allele: APH(3')-Ia
Encodes: aminoglycoside O-phosphotransferase APH(3')-Ia

Mechanism

Enzymatic modification

Confers Resistance To

RIBOSTAMYCINLIVIDOMYCINPAROMOMYCINNEOMYCINKANAMYCIN

Organisms Tested In

• Klebsiella pneumoniae

Antimicrobial susceptibility, plasmid profiles and haemocin activities of Avibacterium paragallinarum strains.

PMID 17485180 · 2007

Gene Information

Gene Name: aph(3')-Ia
Allele: APH(3')-Ia
Encodes: aminoglycoside O-phosphotransferase APH(3')-Ia

Mechanism

Enzymatic modification

Confers Resistance To

NEOMYCINKANAMYCIN

Organisms Tested In

• Avibacterium paragallinarum

Antimicrobial susceptibility, plasmid profiles and haemocin activities of Avibacterium paragallinarum strains.

PMID 17485180 · 2007

Gene Information

Gene Name: aph(3')-Ia
Allele: APH(3')-Ia
Encodes: aminoglycoside O-phosphotransferase APH(3')-Ia

Mechanism

Enzymatic modification

Confers Resistance To

NEOMYCINKANAMYCIN

Organisms Tested In

• Avibacterium paragallinarum

Antimicrobial susceptibility, plasmid profiles and haemocin activities of Avibacterium paragallinarum strains.

PMID 17485180 · 2007

Gene Information

Gene Name: aph(3')-Ia
Allele: APH(3')-Ia
Encodes: aminoglycoside O-phosphotransferase APH(3')-Ia

Mechanism

Enzymatic modification

Confers Resistance To

NEOMYCINKANAMYCIN

Organisms Tested In

• Avibacterium paragallinarum

Antimicrobial susceptibility, plasmid profiles and haemocin activities of Avibacterium paragallinarum strains.

PMID 17485180 · 2007

Gene Information

Gene Name: aph(3')-Ia
Allele: APH(3')-Ia
Encodes: aminoglycoside O-phosphotransferase APH(3')-Ia

Mechanism

Enzymatic modification

Confers Resistance To

NEOMYCINKANAMYCIN

Organisms Tested In

• Avibacterium paragallinarum

Mobilization of qnrB2 and ISCR1 in plasmids.

PMID 19075060 · 2009

Gene Information

Gene Name: aph(3')-Ia
Allele: APH(3')-Ia
Encodes: aminoglycoside O-phosphotransferase APH(3')-Ia

Mechanism

Enzymatic modification

Confers Resistance To

UNKNOWN AMINOGLYCOSIDEKANAMYCIN

Organisms Tested In

• Enterobacter cloacae

Mobilization of qnrB2 and ISCR1 in plasmids.

PMID 19075060 · 2009

Gene Information

Gene Name: aph(3')-Ia
Allele: APH(3')-Ia
Encodes: aminoglycoside O-phosphotransferase APH(3')-Ia

Mechanism

Enzymatic modification

Confers Resistance To

UNKNOWN AMINOGLYCOSIDEKANAMYCIN

Organisms Tested In

• Enterobacter cloacae

Mobilization of qnrB2 and ISCR1 in plasmids.

PMID 19075060 · 2009

Gene Information

Gene Name: aph(3')-Ia
Allele: APH(3')-Ia
Encodes: aminoglycoside O-phosphotransferase APH(3')-Ia

Mechanism

Enzymatic modification

Confers Resistance To

UNKNOWN AMINOGLYCOSIDEKANAMYCIN

Organisms Tested In

• Enterobacter cloacae

Mobilization of qnrB2 and ISCR1 in plasmids.

PMID 19075060 · 2009

Gene Information

Gene Name: aph(3')-Ia
Allele: APH(3')-Ia
Encodes: aminoglycoside O-phosphotransferase APH(3')-Ia

Mechanism

Enzymatic modification

Confers Resistance To

UNKNOWN AMINOGLYCOSIDEKANAMYCIN

Organisms Tested In

• Enterobacter cloacae

Three short fragments of Rts1 DNA are responsible for the temperature-sensitive growth phenotype (Tsg) of host bacteria.

PMID 2013575 · 1991

Gene Information

Gene Name: aph(3')-Ia
Allele: APH(3')-Ia
Encodes: aminoglycoside O-phosphotransferase APH(3')-Ia

Mechanism

Enzymatic modification

Confers Resistance To

KANAMYCIN

Organisms Tested In

• Proteus vulgaris

Three short fragments of Rts1 DNA are responsible for the temperature-sensitive growth phenotype (Tsg) of host bacteria.

PMID 2013575 · 1991

Gene Information

Gene Name: aph(3')-Ia
Allele: APH(3')-Ia
Encodes: aminoglycoside O-phosphotransferase APH(3')-Ia

Mechanism

Enzymatic modification

Confers Resistance To

KANAMYCIN

Organisms Tested In

• Proteus vulgaris

Three short fragments of Rts1 DNA are responsible for the temperature-sensitive growth phenotype (Tsg) of host bacteria.

PMID 2013575 · 1991

Gene Information

Gene Name: aph(3')-Ia
Allele: APH(3')-Ia
Encodes: aminoglycoside O-phosphotransferase APH(3')-Ia

Mechanism

Enzymatic modification

Confers Resistance To

KANAMYCIN

Organisms Tested In

• Proteus vulgaris

Three short fragments of Rts1 DNA are responsible for the temperature-sensitive growth phenotype (Tsg) of host bacteria.

PMID 2013575 · 1991

Gene Information

Gene Name: aph(3')-Ia
Allele: APH(3')-Ia
Encodes: aminoglycoside O-phosphotransferase APH(3')-Ia

Mechanism

Enzymatic modification

Confers Resistance To

KANAMYCIN

Organisms Tested In

• Proteus vulgaris

Embedded elements in the IncPbeta plasmids R772 and R906 can be mobilized and can serve as a source of diverse and novel elements.

PMID 21393370 · 2011

Gene Information

Gene Name: aph(3')-Ia
Allele: APH(3')-Ia
Encodes: aminoglycoside O-phosphotransferase APH(3')-Ia

Mechanism

Enzymatic modification

Confers Resistance To

KANAMYCIN

Organisms Tested In

• Proteus mirabilis

Embedded elements in the IncPbeta plasmids R772 and R906 can be mobilized and can serve as a source of diverse and novel elements.

PMID 21393370 · 2011

Gene Information

Gene Name: aph(3')-Ia
Allele: APH(3')-Ia
Encodes: aminoglycoside O-phosphotransferase APH(3')-Ia

Mechanism

Enzymatic modification

Confers Resistance To

KANAMYCIN

Organisms Tested In

• Proteus mirabilis

Embedded elements in the IncPbeta plasmids R772 and R906 can be mobilized and can serve as a source of diverse and novel elements.

PMID 21393370 · 2011

Gene Information

Gene Name: aph(3')-Ia
Allele: APH(3')-Ia
Encodes: aminoglycoside O-phosphotransferase APH(3')-Ia

Mechanism

Enzymatic modification

Confers Resistance To

KANAMYCIN

Organisms Tested In

• Proteus mirabilis

Embedded elements in the IncPbeta plasmids R772 and R906 can be mobilized and can serve as a source of diverse and novel elements.

PMID 21393370 · 2011

Gene Information

Gene Name: aph(3')-Ia
Allele: APH(3')-Ia
Encodes: aminoglycoside O-phosphotransferase APH(3')-Ia

Mechanism

Enzymatic modification

Confers Resistance To

KANAMYCIN

Organisms Tested In

• Proteus mirabilis

The nucleotide sequence of an aminoglycoside 3'-phosphotransferase gene from E. coli.

PMID 2823223 · 1987

Gene Information

Gene Name: aph(3')-Ia
Allele: APH(3')-Ia
Encodes: aminoglycoside O-phosphotransferase APH(3')-Ia

Mechanism

Enzymatic modification

Confers Resistance To

UNKNOWN AMINOGLYCOSIDEKANAMYCIN

Organisms Tested In

• Escherichia coli

The nucleotide sequence of an aminoglycoside 3'-phosphotransferase gene from E. coli.

PMID 2823223 · 1987

Gene Information

Gene Name: aph(3')-Ia
Allele: APH(3')-Ia
Encodes: aminoglycoside O-phosphotransferase APH(3')-Ia

Mechanism

Enzymatic modification

Confers Resistance To

UNKNOWN AMINOGLYCOSIDEKANAMYCIN

Organisms Tested In

• Escherichia coli

The nucleotide sequence of an aminoglycoside 3'-phosphotransferase gene from E. coli.

PMID 2823223 · 1987

Gene Information

Gene Name: aph(3')-Ia
Allele: APH(3')-Ia
Encodes: aminoglycoside O-phosphotransferase APH(3')-Ia

Mechanism

Enzymatic modification

Confers Resistance To

UNKNOWN AMINOGLYCOSIDEKANAMYCIN

Organisms Tested In

• Escherichia coli

The nucleotide sequence of an aminoglycoside 3'-phosphotransferase gene from E. coli.

PMID 2823223 · 1987

Gene Information

Gene Name: aph(3')-Ia
Allele: APH(3')-Ia
Encodes: aminoglycoside O-phosphotransferase APH(3')-Ia

Mechanism

Enzymatic modification

Confers Resistance To

UNKNOWN AMINOGLYCOSIDEKANAMYCIN

Organisms Tested In

• Escherichia coli

Nucleotide sequence of the kanamycin resistance transposon Tn903.

PMID 6270337 · 1981

Gene Information

Gene Name: aph(3')-Ia
Allele: APH(3')-Ia
Encodes: aminoglycoside O-phosphotransferase APH(3')-Ia

Mechanism

Enzymatic modification

Confers Resistance To

RIBOSTAMYCINLIVIDOMYCINPAROMOMYCINNEOMYCINKANAMYCIN

Organisms Tested In

• Escherichia coli

Nucleotide sequence of the kanamycin resistance transposon Tn903.

PMID 6270337 · 1981

Gene Information

Gene Name: aph(3')-Ia
Allele: APH(3')-Ia
Encodes: aminoglycoside O-phosphotransferase APH(3')-Ia

Mechanism

Enzymatic modification

Confers Resistance To

RIBOSTAMYCINLIVIDOMYCINPAROMOMYCINNEOMYCINKANAMYCIN

Organisms Tested In

• Escherichia coli

Nucleotide sequence of the kanamycin resistance transposon Tn903.

PMID 6270337 · 1981

Gene Information

Gene Name: aph(3')-Ia
Allele: APH(3')-Ia
Encodes: aminoglycoside O-phosphotransferase APH(3')-Ia

Mechanism

Enzymatic modification

Confers Resistance To

RIBOSTAMYCINLIVIDOMYCINPAROMOMYCINNEOMYCINKANAMYCIN

Organisms Tested In

• Escherichia coli

Nucleotide sequence of the kanamycin resistance transposon Tn903.

PMID 6270337 · 1981

Gene Information

Gene Name: aph(3')-Ia
Allele: APH(3')-Ia
Encodes: aminoglycoside O-phosphotransferase APH(3')-Ia

Mechanism

Enzymatic modification

Confers Resistance To

RIBOSTAMYCINLIVIDOMYCINPAROMOMYCINNEOMYCINKANAMYCIN

Organisms Tested In

• Escherichia coli

PMID N/A

Gene Information

Gene Name: aph(3')-Ia
Allele: APH(3')-Ia
Encodes: aminoglycoside O-phosphotransferase APH(3')-Ia

Mechanism

Enzymatic modification

Confers Resistance To

KANAMYCIN

Organisms Tested In

• Salmonella enterica subsp. enterica serovar Typhimurium

PMID N/A

Gene Information

Gene Name: aph(3')-Ia
Allele: APH(3')-Ia
Encodes: aminoglycoside O-phosphotransferase APH(3')-Ia

Mechanism

Enzymatic modification

Confers Resistance To

KANAMYCIN

Organisms Tested In

• Salmonella enterica subsp. enterica serovar Typhimurium

PMID N/A

Gene Information

Gene Name: aph(3')-Ia
Allele: APH(3')-Ia
Encodes: aminoglycoside O-phosphotransferase APH(3')-Ia

Mechanism

Enzymatic modification

Confers Resistance To

KANAMYCIN

Organisms Tested In

• Klebsiella pneumoniae

PMID N/A

Gene Information

Gene Name: aph(3')-Ia
Allele: APH(3')-Ia
Encodes: aminoglycoside O-phosphotransferase APH(3')-Ia

Mechanism

Enzymatic modification

Confers Resistance To

NEOMYCINKANAMYCIN

Organisms Tested In

• Escherichia coli

PMID N/A

Gene Information

Gene Name: aph(3')-Ia
Allele: APH(3')-Ia
Encodes: aminoglycoside O-phosphotransferase APH(3')-Ia

Mechanism

Enzymatic modification

Confers Resistance To

NEOMYCINKANAMYCIN

Organisms Tested In

• Escherichia coli

PMID N/A

Gene Information

Gene Name: aph(3')-Ia
Allele: APH(3')-Ia
Encodes: aminoglycoside O-phosphotransferase APH(3')-Ia

Mechanism

Enzymatic modification

Confers Resistance To

KANAMYCIN

Organisms Tested In

• Klebsiella pneumoniae

PMID N/A

Gene Information

Gene Name: aph(3')-Ia
Allele: APH(3')-Ia
Encodes: aminoglycoside O-phosphotransferase APH(3')-Ia

Mechanism

Enzymatic modification

Confers Resistance To

KANAMYCIN

Organisms Tested In

• Klebsiella pneumoniae

PMID N/A

Gene Information

Gene Name: aph(3')-Ia
Allele: APH(3')-Ia
Encodes: aminoglycoside O-phosphotransferase APH(3')-Ia

Confers Resistance To

KANAMYCIN

Organisms Tested In

• Mannheimia haemolytica

PMID N/A

Gene Information

Gene Name: aph(3')-Ia
Allele: APH(3')-Ia
Encodes: aminoglycoside O-phosphotransferase APH(3')-Ia

Confers Resistance To

KANAMYCIN

Organisms Tested In

• Plasmid pFA6

PMID N/A

Gene Information

Gene Name: aph(3')-Ia
Allele: APH(3')-Ia
Encodes: aminoglycoside O-phosphotransferase APH(3')-Ia

Mechanism

Enzymatic modification

Confers Resistance To

KANAMYCIN

Organisms Tested In

• Salmonella enterica subsp. enterica serovar Typhimurium

PMID N/A

Gene Information

Gene Name: aph(3')-Ia
Allele: APH(3')-Ia
Encodes: aminoglycoside O-phosphotransferase APH(3')-Ia

Mechanism

Enzymatic modification

Confers Resistance To

KANAMYCIN

Organisms Tested In

• Klebsiella pneumoniae

PMID N/A

Gene Information

Gene Name: aph(3')-Ia
Allele: APH(3')-Ia
Encodes: aminoglycoside O-phosphotransferase APH(3')-Ia

Confers Resistance To

KANAMYCIN

Organisms Tested In

• Mannheimia haemolytica

PMID N/A

Gene Information

Gene Name: aph(3')-Ia
Allele: APH(3')-Ia
Encodes: aminoglycoside O-phosphotransferase APH(3')-Ia

Mechanism

Enzymatic modification

Confers Resistance To

KANAMYCIN

Organisms Tested In

• Salmonella enterica subsp. enterica serovar Typhimurium

PMID N/A

Gene Information

Gene Name: aph(3')-Ia
Allele: APH(3')-Ia
Encodes: aminoglycoside O-phosphotransferase APH(3')-Ia

Confers Resistance To

KANAMYCIN

Organisms Tested In

• Plasmid pFA6

PMID N/A

Gene Information

Gene Name: aph(3')-Ia
Allele: APH(3')-Ia
Encodes: aminoglycoside O-phosphotransferase APH(3')-Ia

Mechanism

Enzymatic modification

Confers Resistance To

NEOMYCINKANAMYCIN

Organisms Tested In

• Escherichia coli

PMID N/A

Gene Information

Gene Name: aph(3')-Ia
Allele: APH(3')-Ia
Encodes: aminoglycoside O-phosphotransferase APH(3')-Ia

Mechanism

Enzymatic modification

Confers Resistance To

NEOMYCINKANAMYCIN

Organisms Tested In

• Escherichia coli

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