Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
3′ phosphotransferase
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| aphA-3 | Reslit | 17 | Kanamycin, Aminoglycoside +3 | Enterococcus faecium +16 | Asia|Australasia, Italy, China, Europe, Malaysia, Italy|Spain, Japan, Egypt, Tunisia, Iraq|Afghanistan, Turkey | 2001, 2006, 2008, 2012, 2013, 2015, 2016, 2019, 2020, 2021, 2022, 2024 |
| AF330699 |
| - |
| aphA 3 | Reslit | 1 | Gentamicin, Kanamycin +1 | Staphylococcus sciuri | - | 2017 | - | - |
| aphA-3-1 | Reslit | 1 | Gentamicin | Campylobacter jejuni +1 | Iran | 2023 | - | - |
| aphA-3–1 | Reslit | 1 | Gentamicin, Kanamycin +1 | Arcobacter butzleri +2 | Shahrekord, Iran|Iran | 2024 | - | - |
Aminoglycoside-streptothricin resistance gene cluster aadE-sat4-aphA-3 disseminated among multiresistant isolates of Enterococcus faecium.
The study identifies the aadE-sat4-aphA-3 gene cluster responsible for aminoglycoside and streptothricin resistance in multidrug-resistant Enterococcus faecium isolates.
Simultaneous detection of nine antibiotic resistance-related genes in Streptococcus agalactiae using multiplex PCR and reverse line blot hybridization assay.
The study developed a multiplex PCR and reverse line blot hybridization assay to detect nine antibiotic resistance-related genes in Streptococcus agalactiae, including erm(B), erm(A/TR), mef(A/E), tet(M), tet(O), aphA-3, aad-6, int-Tn, and mreA. These genes were found to be associated with resistance to macrolides, lincosamides, streptogramin B, tetracyclines, and aminoglycosides.
erm(B)-Carrying Elements in Tetracycline-Resistant Pneumococci and Correspondence between Tn1545 and Tn6003.
The study identified and characterized erm(B)-carrying transposons in tetracycline-resistant pneumococci, showing that Tn1545 and Tn6003 have similar resistance gene combinations, including erm(B), tet(M), and aphA-3. It also revealed that Tn6002 was the most common transposon among the isolates.
Identification of a novel genomic island conferring resistance to multiple aminoglycoside antibiotics in Campylobacter coli.
A novel genomic island containing multiple aminoglycoside resistance genes, including aadE, aphA-3, aacA-aphD, and sat4, was identified in Campylobacter coli strains, conferring resistance to multiple aminoglycoside antibiotics.
Comparative genomics of the Staphylococcus intermedius group of animal pathogens.
The study identifies several antibiotic resistance genes in S. pseudintermedius ED99, including bla operon, aad6-sat4-aphA-3, ermB, and tetM, which confer resistance to beta-lactams, aminoglycosides, macrolides, lincosamides, streptogramins, and tetracyclines.
Resistance mechanisms in Campylobacter jejuni.
The paper reviews the resistance mechanisms in Campylobacter jejuni, focusing on fluoroquinolone, macrolide, beta-lactam, tetracycline, and aminoglycoside resistance. Key mechanisms include mutations in gyrA, efflux pumps like CmeABC, modifications of 23S rRNA, and the presence of resistance genes such as aphA-3, TetO, and blaOXA-61.
Prevalence and antimicrobial susceptibility of Vibrio parahaemolyticus isolated from retail shrimps in Malaysia.
The study identified the chloramphenicol resistance gene catA2 and the kanamycin resistance gene aphA-3 in Vibrio parahaemolyticus isolates from retail shrimps in Malaysia.
Antibiotic Susceptibility Profiles of Dairy Leuconostoc, Analysis of the Genetic Basis of Atypical Resistances and Transfer of Genes In Vitro and in a Food Matrix.
The study identified several AMR genes in Leuconostoc strains, including erm(B) for erythromycin resistance, tet(S) for tetracycline resistance, and others like aadE, aphA-3, sat4, and vat(E) for aminoglycoside and virginiamycin resistance.
Whole-Genome Sequencing for Routine Pathogen Surveillance in Public Health: a Population Snapshot of Invasive Staphylococcus aureus in Europe.
The study analyzed 308 invasive Staphylococcus aureus isolates using whole-genome sequencing to identify high-risk clones and understand the distribution of antibiotic resistance mechanisms. It showed that in silico predictions of antibiotic resistance profiles are as reliable as traditional phenotypic testing.
Nasal and pharyngeal carriage of methicillin-resistant Staphylococcus sciuri among hospitalised patients and healthcare workers in a Serbian university hospital.
Novel Multidrug-Resistant Enterococcal Mobile Linear Plasmid pELF1 Encoding vanA and vanM Gene Clusters From a Japanese Vancomycin-Resistant Enterococci Isolate.
The study identifies a novel multidrug-resistant enterococcal mobile linear plasmid pELF1 that encodes vanA and vanM gene clusters, conferring resistance to vancomycin, as well as other antibiotics such as streptomycin, streptothricin, kanamycin, and erythromycin.
Characterization of Staphylococci and Streptococci Isolated from Milk of Bovides with Mastitis in Egypt.
The study identified multiple AMR genes in Staphylococcus and Streptococcus isolates from bovine milk, including blaZ, mecA, erm(C), aac(aph)D, tetK, tetL, tetM, lnuA, erm(A), erm(B), aphA-3, aad-6, and optrA, indicating widespread resistance to beta-lactams, macrolides, aminoglycosides, tetracyclines, and linezolid.
A GC-Rich Prophage-Like Genomic Region of Mycoplasma bovirhinis HAZ141_2 Carries a Gene Cluster Encoding Resistance to Kanamycin and Neomycin.
The study identifies a gene cluster (aadE*-sat4-aphA-3) in Mycoplasma bovirhinis HAZ141_2 that confers resistance to kanamycin, neomycin, and nourseothricin. The cluster was functionally validated by cloning into E. coli and demonstrating resistance through MIC testing.
The aadE*-sat4-aphA-3 Gene Cluster of Mycoplasma bovirhinis HAZ141_2 Undergoes Genomic Rearrangements Influencing the Primary Promoter Sequence.
The aadE*-sat4-aphA-3 gene cluster in Mycoplasma bovirhinis HAZ141_2 undergoes genomic rearrangements, including inversions and deletions, which affect the primary promoter sequence and influence gene expression. The genes aadE*, sat4, and aphA-3 confer resistance to streptomycin, streptothricin/nourseothricin, and kanamycin/neomycin, respectively.
A New Variant of the aadE-sat4-aphA-3 Gene Cluster Found in a Conjugative Plasmid from a MDR Campylobacter jejuni Isolate.
The study identifies a novel variant of the aadE-sat4-aphA-3 gene cluster in the conjugative plasmid pCjH01 from a multidrug-resistant Campylobacter jejuni isolate, which provides resistance to kanamycin and gentamicin.
Virulence Profiling, Multidrug Resistance and Molecular Mechanisms of Campylobacter Strains from Chicken Carcasses in Tunisia.
The study identified multiple AMR genes and mutations in Campylobacter strains from chicken carcasses in Tunisia, highlighting the presence of multidrug-resistant strains with high resistance rates to various antibiotics.
Metagenomic features of bioburden serve as outcome indicators in combat extremity wounds.
The study identifies several AMR genes, including beta-lactamases blaADC-10 and blaADC-25, aminoglycoside phosphotransferase aphA-3, and beta-lactamase blaOXA-50, associated with resistance to beta-lactam and aminoglycoside antibiotics in combat wound bioburden.
Campylobacter spp. isolated from poultry in Iran: Antibiotic resistance profiles, virulence genes, and molecular mechanisms.
The study identified blaOXA-61, tet(O), aadE1, aphA-3-1, and cmeB as key AMR genes in Campylobacter isolates from poultry in Iran, highlighting their role in resistance to beta-lactams, tetracyclines, aminoglycosides, and fluoroquinolones.
Prevalence and antimicrobial resistance of Campylobacter species in shelter-housed healthy and diarrheic cats and dogs in Turkey.
The study identified tetO and aphA-3 genes associated with tetracycline and gentamicin resistance, respectively, in Campylobacter jejuni isolates. Additionally, the Thr-86-Ile mutation in the gyrA gene was found to confer resistance to quinolone antibiotics.
Arcobacter species isolated from human stool samples, animal products, ready-to-eat salad mixes, and ambient water: prevalence, antimicrobial susceptibility, and virulence gene profiles.
The study identified the presence of antimicrobial resistance genes such as tet(O), blaOXA-61, aphA-3–1, and aadE1 in Arcobacter spp. isolates, highlighting the prevalence of resistance to tetracycline, beta-lactams, and aminoglycosides.
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