apha15
aminoglycoside phosphotransferase
NCBI Pathogen Isolates
Bacterial genomes carrying this gene
NCBI Reference Gene Catalog
Known alleles and reference sequences
UniProt
Protein entries specific to apha15
AMR Rules
Browse AMR rules for apha15
Validation StatusCandidate
Overview
- Mechanism
- phosphorylation of aminoglycosides
- Validation Method
- expression in E. coli and MIC testing
- Drug Classes
- kanamycin, neomycin
- Organisms
- Escherichia coli
- Geographic Location
- Italy
- Papers
- 1
- Databases
- Reslit
Papers1
1
In70 of plasmid pAX22, a bla(VIM-1)-containing integron carrying a new aminoglycoside phosphotransferase gene cassette.
The study identifies a new integron, In70, carrying the bla(VIM-1) gene, which confers resistance to beta-lactams, including carbapenems, and three aminoglycoside resistance genes: aacA4, aphA15, and aadA1.
Gene Information
- Gene Name
- apha15
- Allele
- aphA15
- Encodes
- aminoglycoside phosphotransferase
- Source Database
- Reslit
- Mechanism
- phosphorylation of aminoglycosides
- Confers Resistance To
- kanamycinneomycin
- Organisms Tested In
- • Escherichia coli
- Geographic Location
- Italy
- Validation Method
- expression in E. coli and MIC testing
- Sequence Accession
- AJ278514|AJ278515
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