apha1a

aminoglycoside-3'-phosphotransferase

Validation StatusSupported

Overview

Mechanism: confers resistance to kanamycin and neomycin
Validation Method: experimental validation through plasmid construction and PCR
Drug Classes: Kanamycin, Neomycin, Aminoglycoside
Organisms: Escherichia coli, Salmonella enterica serovar Typhimurium, Klebsiella pneumoniae, Acinetobacter baumannii
Geographic Location: Australia|US|UK, China
Papers: 5
Databases: Reslit

Papers5

IS26-Mediated Precise Excision of the IS26-aphA1a Translocatable Unit.

PMID 26646012 · 2015

The study characterizes the precise excision of the IS26-aphA1a translocatable unit, demonstrating that the aphA1a gene confers resistance to kanamycin and neomycin. The excision process is dependent on the IS26 transposase Tnp26 and is influenced by specific G nucleotide sequences.

Gene Information

Gene Name: apha1a
Allele: aphA1a
Encodes: aminoglycoside-3'-phosphotransferase
Source Database: Reslit
Mechanism: confers resistance to kanamycin and neomycin
Confers Resistance To: KanamycinNeomycin
Organisms Tested In: • Escherichia coli
Validation Method: experimental validation through plasmid construction and PCR
Sequence Accession: KF976462|KT207463

Antibiotic Resistance, Core-Genome and Protein Expression in IncHI1 Plasmids in Salmonella Typhimurium.

PMID 27189997 · 2016

The study identified multiple antibiotic resistance genes in IncHI1 plasmids of Salmonella Typhimurium, including tet(B), tet(A), blaTEM, strA, strB, sul2, aadA, dfrA, catA1, aphA1a, and aad(3)IId, which confer resistance to various antibiotics such as tetracycline, beta-lactam, streptomycin, sulfonamide, aminoglycoside, chloramphenicol, and trimethoprim.

Gene Information

Gene Name: apha1a
Allele: aphA1a
Encodes: aminoglycoside resistance
Source Database: Reslit
Confers Resistance To: Aminoglycoside
Organisms Tested In: • Salmonella enterica serovar Typhimurium
Validation Method: plasmid sequencing and annotation
Sequence Accession: KP899806|KP899805|KP899804|KP899803

IS26-Mediated Formation of Transposons Carrying Antibiotic Resistance Genes.

PMID 27303727 · 2016

The study demonstrates that IS26 facilitates the formation of transposons carrying antibiotic resistance genes through a conservative reaction, leading to the creation of IS26-bounded transposons. Specifically, the aphA1a and tet(D) genes were shown to confer resistance to kanamycin/neomycin and tetracycline, respectively.

Gene Information

Gene Name: apha1a
Allele: aphA1a
Encodes: kanamycin and neomycin resistance determinant
Source Database: Reslit
Confers Resistance To: KanamycinNeomycin
Organisms Tested In: • Escherichia coli
Validation Method: transformation and PCR screening

Genomic characterization of novel IncFII-type multidrug resistant plasmids p0716-KPC and p12181-KPC from Klebsiella pneumoniae.

PMID 28725038 · 2017

The study characterizes two novel IncFII-type multidrug-resistant plasmids, p0716-KPC and p12181-KPC, from Klebsiella pneumoniae. These plasmids carry multiple resistance genes, including blaKPC-2, mph(A), strAB, aacC2, qacEΔ1, sul1, sul2, dfrA25, aphA1a, and blaTEM-1, contributing to resistance against various antibiotics.

Gene Information

Gene Name: apha1a
Allele: aphA1a
Encodes: aminoglycoside phosphotransferase
Source Database: Reslit
Confers Resistance To: Aminoglycoside
Organisms Tested In: • Klebsiella pneumoniae
• Escherichia coli
Geographic Location: China
Validation Method: plasmid conjugation and transformation
Sequence Accession: KY270849|KY270850

Genetic structure of four plasmids found in Acinetobacter baumannii isolate D36 belonging to lineage 2 of global clone 1.

PMID 30260997 · 2018

The study identifies four plasmids in Acinetobacter baumannii isolate D36, including pRAY* carrying aadB, pD36-4 carrying aphA1a, sul2, and a mercury resistance module, and others with no resistance genes.

Gene Information

Gene Name: apha1a
Allele: aphA1a
Encodes: kanamycin and neomycin resistance gene
Source Database: Reslit
Confers Resistance To: KanamycinNeomycin
Organisms Tested In: • Acinetobacter baumannii
Geographic Location: Australia|US|UK
Validation Method: plasmid sequencing and functional analysis
Sequence Accession: CP012953|CP012954|CP012955|CP012956|CP012952|CP020587|KT965093|KJ616406|CP010903|DQ278485|CP015595|CP021429|CP021348|CP027365

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apha1a

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