arcA

global regulator

Validation StatusSupported

Overview

Mechanism: confers resistance to reactive nitrogen and oxygen intermediates
Validation Method: transformation of genomic DNA library and complementation studies
Drug Classes: Beta-lactams, Ciprofloxacin|Colistin
Organisms: Salmonella enterica serovar Enteritidis, Bovine, Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Salmonella enterica
Geographic Location: Thailand, United States
Papers: 6
Databases: Reslit
Mutations: 1

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
S104P	AGT->CCC	-	Salmonella enterica	Ciprofloxacin\|Colistin	Reslit	Candidate

Papers6

The global regulator ArcA controls resistance to reactive nitrogen and oxygen intermediates in Salmonella enterica serovar Enteritidis.

PMID 11796570 · 2002

The study identifies ArcA as a critical global regulator involved in resistance to reactive nitrogen and oxygen intermediates in Salmonella enterica serovar Enteritidis.

Gene Information

Gene Name: arcA
Allele: arcA
Encodes: global regulator
Source Database: Reslit
Mechanism: confers resistance to reactive nitrogen and oxygen intermediates
Organisms Tested In: • Salmonella enterica serovar Enteritidis
Validation Method: transformation of genomic DNA library and complementation studies

Animal Breed Composition Is Associated With the Hindgut Microbiota Structure and β-Lactam Resistance in the Multibreed Angus-Brahman Herd.

PMID 31456774 · 2019

The study found that β-lactam resistance genes, including ampC and arcA, were more abundant in postweaning heifers with a higher Brahman proportion.

Gene Information

Gene Name: arcA
Allele: arcA
Encodes: membrane fusion protein
Source Database: Reslit
Confers Resistance To: Beta-lactams
Organisms Tested In: • Bovine
Geographic Location: United States
Validation Method: qPCR and metagenomic sequencing

Suppression of antibiotic resistance evolution by single-gene deletion.

PMID 32144279 · 2020

Deletion of arcA and gutM significantly suppressed antibiotic resistance evolution in E. coli, suggesting their roles in metabolic regulation and stress resistance.

Gene Information

Gene Name: arcA
Allele: arcA
Encodes: global regulator of gene expression under microaerobic and anaerobic growth conditions
Source Database: Reslit
Mechanism: regulation of aerobic respiration and metabolic shifts
Organisms Tested In: • Escherichia coli
Validation Method: laboratory evolution and IC50 measurements

The dynamic transcriptome during maturation of biofilms formed by methicillin-resistant Staphylococcus aureus.

PMID 35966712 · 2022

The study identifies clfA as a significantly upregulated gene in 24-h biofilms across all three MRSA strains, highlighting its potential as a target for disrupting early biofilm formation. The arginine deiminase (ADI) pathway, including genes arcA, arcB, arcC, and arcD, is upregulated during biofilm formation, suggesting a role in energy metabolism. Disruption of opp3D in USA300-JE2 significantly reduces biofilm formation, indicating its importance in biofilm development.

Gene Information

Gene Name: arcA
Allele: arcA
Encodes: arginine deiminase
Source Database: Reslit
Organisms Tested In: • Staphylococcus aureus
Validation Method: differential gene expression analysis

Hydroquinine Inhibits the Growth of Multidrug-Resistant Pseudomonas aeruginosa via the Suppression of the Arginine Deiminase Pathway Genes.

PMID 37762218 · 2023

Hydroquinine inhibits the growth of multidrug-resistant P. aeruginosa by suppressing the arginine deiminase (ADI) pathway genes, including arcA, arcB, arcC, and arcD. This leads to reduced expression of these genes, which are involved in energy production and bacterial growth.

Gene Information

Gene Name: arcA
Allele: arcA
Encodes: arginine deiminase
Source Database: Reslit
Organisms Tested In: • Pseudomonas aeruginosa
Geographic Location: Thailand
Validation Method: RT-qPCR

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arcA

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