armA

16S rRNA (guanine(1405)-N(7))-methyltransferase ArmA

Validation StatusConfirmed2+ DBs

Overview

Mechanism: Target protection
Validation Method: cloning into E. coli and susceptibility testing
Drug Classes: TOBRAMYCIN, ISEPAMICIN, AMIKACIN, NETILMICIN, GENTAMICIN, amikacin, dibekacin, 5-episisomicin, fortimicin, isepamicin, gentamicin, kanamycin, netilmicin, 2'- and 6'-n-ethylnetilmicin, sisomicin, tobramycin, 4,6-disubstituted deoxystreptamines
Organisms: Klebsiella pneumoniae, Enterobacteriaceae, Escherichia coli, Citrobacter freundii, Enterobacter cloacae, Salmonella enterica, Shigella flexneri
Geographic Location: France|Bulgaria|India|Turkey
Papers: 2
Databases: Card DatabaseReference Gene CatalogResFinder DatabaseReslit

Papers2

Plasmid-mediated high-level resistance to aminoglycosides in Enterobacteriaceae due to 16S rRNA methylation.

PMID 12878520 · 2003

Gene Information

Gene Name: armA
Allele: ArmA
Encodes: 16S rRNA (guanine(1405)-N(7))-methyltransferase ArmA
Source Database: Card Database
Mechanism: Target protection
Confers Resistance To: TOBRAMYCINISEPAMICINAMIKACINNETILMICINGENTAMICIN
Organisms Tested In: • Klebsiella pneumoniae
Sequence Accession: AY220558.1
Protein Accession: AAP50754.1
Notes: ARO:3000858

Plasmid-mediated high-level resistance to aminoglycosides in Enterobacteriaceae due to 16S rRNA methylation.

PMID 12878520 · 2003

The study identifies the armA gene, which encodes a 16S rRNA m7G methyltransferase, as responsible for plasmid-mediated high-level resistance to a wide range of aminoglycosides in Enterobacteriaceae.

Gene Information

Gene Name: armA
Allele: ArmA
Encodes: 16S rRNA m7G methyltransferase
Source Database: Reslit
Mechanism: posttranscriptional methylation of 16S rRNA
Confers Resistance To: amikacindibekacin5-episisomicinfortimicinisepamicingentamicinkanamycinnetilmicin2'- and 6'-n-ethylnetilmicinsisomicintobramycin
Organisms Tested In: • Enterobacteriaceae
• Escherichia coli
Validation Method: cloning into E. coli and susceptibility testing
Sequence Accession: AY220558

Plasmid-mediated high-level resistance to aminoglycosides in Enterobacteriaceae due to 16S rRNA methylation.

PMID 12878520 · 2003

Gene Information

Gene Name: armA
Allele: ArmA
Encodes: 16S rRNA (guanine(1405)-N(7))-methyltransferase ArmA
Source Database: Reference Gene Catalog
Mechanism: Target protection
Confers Resistance To: TOBRAMYCINISEPAMICINAMIKACINNETILMICINGENTAMICIN
Organisms Tested In: • Klebsiella pneumoniae
Sequence Accession: AY220558.1
Protein Accession: AAP50754.1
Notes: ARO:3000858

Plasmid-mediated high-level resistance to aminoglycosides in Enterobacteriaceae due to 16S rRNA methylation.

PMID 12878520 · 2003

Gene Information

Gene Name: armA
Allele: ArmA
Encodes: 16S rRNA (guanine(1405)-N(7))-methyltransferase ArmA
Source Database: ResFinder Database
Mechanism: Target protection
Confers Resistance To: TOBRAMYCINISEPAMICINAMIKACINNETILMICINGENTAMICIN
Organisms Tested In: • Klebsiella pneumoniae
Sequence Accession: AY220558.1
Protein Accession: AAP50754.1
Notes: ARO:3000858

Plasmid-mediated high-level resistance to aminoglycosides in Enterobacteriaceae due to 16S rRNA methylation.

PMID 12878520 · 2003

Gene Information

Gene Name: armA
Allele: ArmA
Encodes: 16S rRNA (guanine(1405)-N(7))-methyltransferase ArmA
Source Database: Card Database
Mechanism: Target protection
Confers Resistance To: TOBRAMYCINISEPAMICINAMIKACINNETILMICINGENTAMICIN
Organisms Tested In: • Klebsiella pneumoniae
Sequence Accession: AY220558.1
Protein Accession: AAP50754.1
Notes: ARO:3000858

Plasmid-mediated high-level resistance to aminoglycosides in Enterobacteriaceae due to 16S rRNA methylation.

PMID 12878520 · 2003

Gene Information

Gene Name: armA
Allele: ArmA
Encodes: 16S rRNA (guanine(1405)-N(7))-methyltransferase ArmA
Source Database: Reference Gene Catalog
Mechanism: Target protection
Confers Resistance To: TOBRAMYCINISEPAMICINAMIKACINNETILMICINGENTAMICIN
Organisms Tested In: • Klebsiella pneumoniae
Sequence Accession: AY220558.1
Protein Accession: AAP50754.1
Notes: ARO:3000858

Plasmid-mediated high-level resistance to aminoglycosides in Enterobacteriaceae due to 16S rRNA methylation.

PMID 12878520 · 2003

Gene Information

Gene Name: armA
Allele: ArmA
Encodes: 16S rRNA (guanine(1405)-N(7))-methyltransferase ArmA
Source Database: ResFinder Database
Mechanism: Target protection
Confers Resistance To: TOBRAMYCINISEPAMICINAMIKACINNETILMICINGENTAMICIN
Organisms Tested In: • Klebsiella pneumoniae
Sequence Accession: AY220558.1
Protein Accession: AAP50754.1
Notes: ARO:3000858

Worldwide Disseminated armA Aminoglycoside Resistance Methylase Gene Is Borne by Composite Transposon Tn1548.

PMID 15980373 · 2005

The armA gene, which confers resistance to 4,6-disubstituted deoxystreptamines and fortimicin, was found to be part of the composite transposon Tn1548, which is flanked by two copies of IS6 and is capable of replicative transposition.

Gene Information

Gene Name: armA
Allele: ArmA
Encodes: aminoglycoside resistance methylase
Source Database: Reslit
Confers Resistance To: 4,6-disubstituted deoxystreptaminesfortimicin
Organisms Tested In: • Klebsiella pneumoniae
• Citrobacter freundii
• Enterobacter cloacae
• Escherichia coli
• Salmonella enterica
• Shigella flexneri
Geographic Location: France|Bulgaria|India|Turkey
Validation Method: PCR, sequencing, conjugation experiments
Sequence Accession: AF550415|U27435

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