Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
hypothetical protein
Overview
The sensor kinase CbrA is a global regulator that modulates metabolism, virulence, and antibiotic resistance in Pseudomonas aeruginosa.
The study identifies that the sensor kinase CbrA regulates antibiotic resistance in Pseudomonas aeruginosa through the upregulation of genes involved in lipid A modification and resistance to polymyxins, including oprH, phoP, phoQ, arnB, arnC, arnA, arnD, arnT, arnE, arnF, and pmrB.
Selective labelling and eradication of antibiotic-tolerant bacterial populations in Pseudomonas aeruginosa biofilms.
The study identifies ArnA and PmrA as polymyxin-resistance proteins that are highly expressed in colistin-tolerant Pseudomonas aeruginosa biofilms, contributing to their tolerance to colistin.
The polymyxin B-induced transcriptomic response of a clinical, multidrug-resistant Klebsiella pneumoniae involves multiple regulatory elements and intracellular targets.
The study identified a truncated mgrB gene as a potential mechanism for polymyxin B resistance in a multidrug-resistant Klebsiella pneumoniae strain.
Multidrug resistant pathogens respond differently to the presence of co-pathogen, commensal, probiotic and host cells.
The study identifies several AMR genes and their expression changes in response to co-culturing with other bacteria and host cells, highlighting the dynamic nature of AMR gene regulation in multidrug-resistant organisms.
Detection of critical antibiotic resistance genes through routine microbiome surveillance.
The study identifies various antibiotic resistance genes (ARGs) associated with multidrug resistance, including macrolide, beta-lactam, tetracycline, and methicillin resistance genes, highlighting the presence of these genes in postmortem microbiome samples.
High-Risk International Clones of Carbapenem-Nonsusceptible Pseudomonas aeruginosa Endemic to Indonesian Intensive Care Units: Impact of a Multifaceted Infection Control Intervention Analyzed at the Genomic Level.
The study identified several carbapenemase-encoding genes (blaGES-5, blaIMP-1, blaIMP-7, blaIMP-43, blaVIM-2, and blaVIM-8) and mutations in the porin gene oprD that contribute to carbapenem resistance in Pseudomonas aeruginosa isolates from Indonesian ICUs.
Metagenomic read cloud sequencing reveals antibiotic resistance gene dynamics in the gut microbiome of a hematopoietic cell transplant patient
The study identified 46 antibiotic resistance genes in the pre-transplant E. coli strain, including genes conferring resistance to beta-lactams, aminoglycosides, polymyxins, bacitracin, and multiple drugs through efflux pumps.
Functional metagenomics reveals antibiotic resistance determinants in dairy-associated microbial communities
The study identified several antibiotic resistance (AR) determinants in dairy products and processing environments, including genes conferring resistance to beta-lactams, tetracyclines, glycopeptides, macrolides, and streptogramins. Notably, Lactococcus lactis was found to be a significant reservoir of multidrug-resistant genes.
Predicting Phenotypic Polymyxin Resistance in Klebsiella pneumoniae through Machine Learning Analysis of Genomic Data.
The study identifies several genes associated with polymyxin resistance in Klebsiella pneumoniae using machine learning analysis of genomic data, including known resistance determinants and potential novel genes.
Whole Genome Sequencing and Characterization of Multidrug-Resistant (MDR) Bacterial Strains Isolated From a Norwegian University Campus Pond.
The study identifies multiple AMR genes and mutations in ESBL-producing bacteria from Norwegian freshwater environments, highlighting the presence of multidrug-resistant strains with resistance to various antibiotics including beta-lactams, fluoroquinolones, and sulfonamides.
Isolation and characterization of Uropathogenic Escherichia coli (UPEC) from red panda (Ailurus fulgens).
The study identified a Uropathogenic Escherichia coli (UPEC) strain isolated from a red panda that exhibited resistance to multiple antibiotics, including aminoglycosides, beta-lactams, and macrolides. The strain possessed 20 resistance genes, such as acra, acrb, mdte, mdtf, mdtn, mdto, mdtp, tolc, arna, baca, bcr, bl1_ec, emre, ksga, macb, mdfa, mdtg, mdth, mdtk, and mdtl, which contribute to multidrug resistance.
Transcriptome changes and polymyxin resistance of acid-adapted Escherichia coli O157:H7 ATCC 43889.
The study identifies the polymyxin resistance gene arnA as being upregulated in acid-adapted E. coli O157:H7 ATCC 43889, leading to increased resistance against polymyxin B and colistin.
Antibiotic Resistance and Phylogeny of Pseudomonas spp. Isolated over Three Decades from Chicken Meat in the Norwegian Food Chain.
The study identified several AMR genes and mutations in Pseudomonas spp. isolated from chicken meat in Norway, including beta-lactamases, efflux pumps, and genes involved in resistance to aminoglycosides, fluoroquinolones, and colistin.
Transcriptome Analysis of Pseudomonas aeruginosa Biofilm Infection in an Ex Vivo Pig Model of the Cystic Fibrosis Lung.
The study identifies that the arnA and crpP genes are differentially expressed in Pseudomonas aeruginosa biofilms grown in an ex vivo pig lung model compared to in vitro conditions, leading to increased resistance to colistin and polymyxin B.
Identification of a Multidrug Resistant Pseudomonas aeruginosa Isolate Harboring Infrequent Red Fluorescence Plasmid from COPD Patient.
The study identifies a multidrug-resistant Pseudomonas aeruginosa isolate L1a harboring an infrequent red fluorescence plasmid. The isolate shows resistance to several antibiotics including levofloxacin, cefepime, aztreonam, and imipenem, and carries multiple drug resistance genes and efflux pump-related genes.
A novel approach for combining the metagenome, metaresistome, metareplicome and causal inference to determine the microbes and their antibiotic resistance gene repertoire that contribute to dysbiosis.
The study identifies specific antibacterial resistance (ABR) genes that may contribute to exponential cell division in the presence of antibiotics for various pathogens, including Klebsiella pneumoniae, Citrobacter freundii, Staphylococcus epidermidis, Veillonella parvula, and Clostridium perfringens.
Antibiotic Resistance Diagnosis in ESKAPE Pathogens-A Review on Proteomic Perspective.
This review discusses proteomic approaches for diagnosing antibiotic resistance in ESKAPE pathogens, highlighting the importance of proteomic techniques in understanding resistance mechanisms and improving diagnostic accuracy.
Metaproteomic Analysis of Gut Resistome in the Cecal Microbiota of Fattening Pigs Raised without Antibiotics.
The study identified several AMR genes, including APH(3'), CTX-M-14, ArnA, MdtL, CatB2, TetQ, TetR, Cas1, and Cas9, in the cecal microbiota of pigs raised with and without antibiotics. These genes were associated with resistance to aminoglycosides, beta-lactams, polymyxin, tetracycline, and other antibiotics.
Impact of antimicrobial use on abundance of antimicrobial resistance genes in chicken flocks in Vietnam.
The study found that antimicrobial resistance genes (ARGs) such as mcr-1, arnA, blaCTX-M, blaSHV, erm, and mcr-3 were prevalent in chicken flocks in Vietnam, with variations in abundance across different production stages. The intervention reduced antimicrobial use but had inconsistent effects on ARGs depending on the measurement metric.
Antibiotic resistance, bacterial transmission and improved prediction of bacterial infection in patients with antibody deficiency.
The study identifies high levels of antibiotic resistance in respiratory tract bacteria from patients with antibody deficiency, particularly macrolide resistance genes erm(B) and mef(A), and highlights the role of commensal streptococci as reservoirs for resistance genes.
Bacterial diversity and resistome analysis of drinking water stored in cisterns from two First Nations communities in Manitoba, Canada.
The study identified a diverse array of antimicrobial resistance genes in drinking water stored in cisterns from two First Nations communities in Manitoba, Canada. Key findings include the presence of genes such as aac(3')-Ia, aac(6')-Iia, aac(6')-Iic, aph(3')-Ia, acrD, smeB, smeR, FEZ-1, rm3, SPG-1, OXA-21, OXA-119, OXA-205, dfrA14, dfrB6, acrB, acrF, adeF, ceoB, emrA, mexE, mexF, mexI, oprN, oqxB, BRP(MBL), vanSO, axyY, CRP, efrB, macB, mexB, mexC, mexD, mexK, mexQ, mexW, mexY, mtrA, muxB, muxC, oleB, oleC, ompB, oprM, smeD, smeE, golS, mdsB, PER-2, TEM-126, msbA, arnA, bacA, bcrA, MCR-5, rosA, rosB, rpoB2, ugd, mexN, taeA, efpA, rphA, rphB, otr(A), otrC, tetA(48 ), ompH, and triC, which confer resistance to various antibiotics including aminoglycosides, beta-lactams, cephalosporins, carbapenems, fluoroquinolones, macrolides, monobactams, nitroimidazoles, peptides, phenicols, pleuromutilins, rifamycins, tetracyclines, and triclosan.
Investigating the resistome of haemolytic bacteria in Arctic soils.
The study identified multiple AMR genes in Arctic haemolytic bacteria, including genes encoding efflux pumps and ribosomal protection proteins, indicating the presence of resistance mechanisms against various antibiotics.
Essential oils modulate virulence phenotypes in a multidrug-resistant pyomelanogenic Pseudomonas aeruginosa clinical isolate.
The study identifies multiple AMR genes in the MDR P. aeruginosa strain U804, including beta-lactamases, aminoglycoside modifying enzymes, and efflux pumps, which contribute to its resistance against various antibiotics.
Clinical characteristics, molecular epidemiology and mechanisms of colistin heteroresistance in Enterobacter cloacae complex.
The study identified several genes and mutations involved in colistin heteroresistance in Enterobacter cloacae complex, including mgrB, phoP, phoQ, arnA, acrB, ramA, and soxS. Mutations in phoQ and mgrB were also found to contribute to colistin heteroresistance.
Induction of lipid A modification genes in Pseudomonas aeruginosa cells tolerant to a commercially available contact lens disinfection solution.
The study identifies arnA as a key gene involved in lipid A modification, which contributes to Pseudomonas aeruginosa's tolerance to a commercial contact lens disinfection solution.
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