arsr3

regulatory protein

Validation StatusCandidate

Overview

Mechanism: regulates expression of the ars gene cluster in response to arsenite
Validation Method: cloning in E. coli + resistance assays
Organisms: Ochrobactrum tritici SCII24, Escherichia coli, Burkholderia xenovorans LB400, Pseudomonas aeruginosa
Papers: 2
Databases: Reslit

Papers2

Sequencing and expression of two arsenic resistance operons with different functions in the highly arsenic-resistant strain Ochrobactrum tritici SCII24T.

PMID 18554386 · 2008

The study identifies two arsenic resistance operons, ars1 and ars2, in Ochrobactrum tritici SCII24T, which confer resistance to arsenite, antimonite, and arsenate. The genes within these operons were cloned and functionally validated in E. coli.

Gene Information

Gene Name: arsr3
Allele: arsR3
Encodes: regulatory protein
Source Database: Reslit
Organisms Tested In: • Ochrobactrum tritici SCII24
• Escherichia coli
Validation Method: cloning in E. coli + resistance assays
Sequence Accession: DQ490089|DQ490090

Analysis of the ars gene cluster from highly arsenic-resistant Burkholderia xenovorans LB400.

PMID 30203106 · 2018

The ars gene cluster from Burkholderia xenovorans LB400 includes arsR3, acr3, arsC1, and arsH, which collectively confer resistance to arsenite and arsenate through transcriptional regulation, efflux, and enzymatic reduction.

Gene Information

Gene Name: arsr3
Allele: arsR3
Encodes: transcriptional repressor
Source Database: Reslit
Mechanism: regulates expression of the ars gene cluster in response to arsenite
Organisms Tested In: • Burkholderia xenovorans LB400
• Escherichia coli
• Pseudomonas aeruginosa
Validation Method: cloning and susceptibility assays

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arsr3

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