asnb
glutamine-dependent asparagine synthetase
NCBI Pathogen Isolates
Bacterial genomes carrying this gene
NCBI Reference Gene Catalog
Known alleles and reference sequences
UniProt
Protein entries specific to asnb
AMR Rules
Browse AMR rules for asnb
Validation StatusCandidate
Overview
- Validation Method
- transformation of the mutant with wild-type asnB of mc 2 155 or asnB of Mycobacterium tuberculosis complemented the drug sensitivity phenotype
- Drug Classes
- rifampin, erythromycin, novobiocin, fusidic acid
- Organisms
- Mycobacterium smegmatis, Mycobacterium tuberculosis
- Papers
- 1
- Databases
- Reslit
Papers1
1
AsnB is involved in natural resistance of Mycobacterium smegmatis to multiple drugs.
The study identifies AsnB as a gene involved in the natural resistance of Mycobacterium smegmatis to multiple drugs, including rifampin, erythromycin, novobiocin, and fusidic acid. Disruption of the asnB gene leads to increased sensitivity to these antibiotics.
Gene Information
- Gene Name
- asnb
- Allele
- asnB
- Encodes
- glutamine-dependent asparagine synthetase
- Source Database
- Reslit
- Confers Resistance To
- rifampinerythromycinnovobiocinfusidic acid
- Organisms Tested In
- • Mycobacterium smegmatis• Mycobacterium tuberculosis
- Validation Method
- transformation of the mutant with wild-type asnB of mc 2 155 or asnB of Mycobacterium tuberculosis complemented the drug sensitivity phenotype
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