atpA

F0F1 H+-ATPase subunit A

Validation StatusSupported

Overview

Mechanism: point mutation
Validation Method: nucleotide sequencing and comparison
Drug Classes: Gentamicin, Polymyxin b, Colistin, Tetracycline, Aminoglycoside, Fluoroquinolone, Macrolide, Polymyxin
Organisms: Streptococcus pneumoniae, Streptococcus mitis, Staphylococcus aureus JE2, Escherichia coli, Staphylococcus aureus, Moraxella catarrhalis
Geographic Location: Argentina
Papers: 5
Databases: Reslit

Papers5

Genetic characterization of optochin-susceptible viridans group streptococci.

PMID 14506029 · 2003

The study identifies the genetic basis for optochin susceptibility in viridans group streptococci, showing that the atpC and atpA genes from Streptococcus pneumoniae contribute to optochin susceptibility in Streptococcus mitis.

Gene Information

Gene Name: atpA
Allele: atpA
Encodes: F0F1 H+-ATPase subunit A
Source Database: Reslit
Organisms Tested In: • Streptococcus pneumoniae
• Streptococcus mitis
Validation Method: nucleotide sequencing and comparison
Sequence Accession: AY172982|AY172983|AY172984|AY172985|AY172986|AY314979|AY314980

Characterization of in vitro-generated and clinical optochin-resistant strains of Streptococcus pneumoniae isolated from Argentina.

PMID 18417665 · 2008

The study identifies mutations in the atpC and atpA genes of Streptococcus pneumoniae that confer optochin resistance. Specifically, G47V in atpC and W206C in atpA were found to be responsible for optochin resistance in clinical and in vitro-generated strains.

Gene Information

Gene Name: atpA
Allele: atpA
Encodes: F0F1 ATPase subunit A
Source Database: Reslit
Mechanism: point mutation
Organisms Tested In: • Streptococcus pneumoniae
Geographic Location: Argentina
Validation Method: transformation of wild-type R6 strain with PCR products
Sequence Accession: EU179872|EU179873|EU179874|EU179875|EU179876|EU179877|EU179878|EU256631|EU256624|EU256625|EU256626|EU256627|EU256628|EU256629|EU256630|EU256632|EU256633|EU256634|EU256635|EU256636

Genome-Wide Identification of Antimicrobial Intrinsic Resistance Determinants in Staphylococcus aureus.

PMID 28066345 · 2016

The study identifies multiple intrinsic resistance determinants in Staphylococcus aureus, including genes such as atpA, rpsT, vraG, and mecA, which contribute to resistance against various antimicrobial agents. These findings highlight potential targets for developing antimicrobial potentiators.

Gene Information

Gene Name: atpA
Allele: atpA
Encodes: ATP synthase subunit
Source Database: Reslit
Mechanism: Membrane potential regulation
Confers Resistance To: Gentamicin
Organisms Tested In: • Staphylococcus aureus JE2
• Escherichia coli
Validation Method: E-test and chromosomal reconstruction

Inhibition of the ATP Synthase Eliminates the Intrinsic Resistance of Staphylococcus aureus towards Polymyxins.

PMID 28874470 · 2017

The study identifies the ATP synthase as a novel target for enhancing the efficacy of polymyxins against Staphylococcus aureus by demonstrating that inactivation of ATP synthase subunits increases susceptibility to polymyxins and colistin.

Gene Information

Gene Name: atpA
Allele: atpA
Encodes: ATP synthase F1, alpha subunit
Source Database: Reslit
Mechanism: intrinsic resistance
Confers Resistance To: Polymyxin bColistin
Organisms Tested In: • Staphylococcus aureus
Validation Method: transposon mutagenesis and MIC testing

An integrated complete-genome sequencing and systems biology approach to predict antimicrobial resistance genes in the virulent bacterial strains of Moraxella catarrhalis.

PMID 36881677 · 2023

The study identified several genes associated with antimicrobial resistance in Moraxella catarrhalis, including rpoB, atpA, fusA, groEL, and rpoL, which are involved in resistance to various antibiotics.

Gene Information

Gene Name: atpA
Allele: atpA
Encodes: ATP synthase subunit alpha
Source Database: Reslit
Mechanism: resistance to multiple antibiotics
Confers Resistance To: TetracyclineAminoglycosideFluoroquinoloneMacrolidePolymyxin
Organisms Tested In: • Moraxella catarrhalis
Validation Method: computational analysis

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