atpC

F0F1 H+-ATPase subunit C

Validation StatusCandidate

Overview

Mechanism: point mutation
Validation Method: nucleotide sequencing and comparison
Drug Classes: Bedaquiline
Organisms: Streptococcus pneumoniae, Streptococcus mitis, Mycobacterium smegmatis
Geographic Location: Argentina
Papers: 3
Databases: Reslit
Mutations: 1

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
W16A	TGG->GCG	-	Mycobacterium smegmatis	Bedaquiline	Reslit	Candidate

Papers3

Genetic characterization of optochin-susceptible viridans group streptococci.

PMID 14506029 · 2003

The study identifies the genetic basis for optochin susceptibility in viridans group streptococci, showing that the atpC and atpA genes from Streptococcus pneumoniae contribute to optochin susceptibility in Streptococcus mitis.

Gene Information

Gene Name: atpC
Allele: atpC
Encodes: F0F1 H+-ATPase subunit C
Source Database: Reslit
Organisms Tested In: • Streptococcus pneumoniae
• Streptococcus mitis
Validation Method: nucleotide sequencing and comparison
Sequence Accession: AY172982|AY172983|AY172984|AY172985|AY172986|AY314979|AY314980

Characterization of in vitro-generated and clinical optochin-resistant strains of Streptococcus pneumoniae isolated from Argentina.

PMID 18417665 · 2008

The study identifies mutations in the atpC and atpA genes of Streptococcus pneumoniae that confer optochin resistance. Specifically, G47V in atpC and W206C in atpA were found to be responsible for optochin resistance in clinical and in vitro-generated strains.

Gene Information

Gene Name: atpC
Allele: atpC
Encodes: F0F1 ATPase subunit C
Source Database: Reslit
Mechanism: point mutation
Organisms Tested In: • Streptococcus pneumoniae
Geographic Location: Argentina
Validation Method: transformation of wild-type R6 strain with PCR products
Sequence Accession: EU179872|EU179873|EU179874|EU179875|EU179876|EU179877|EU179878|EU256631|EU256624|EU256625|EU256626|EU256627|EU256628|EU256629|EU256630|EU256632|EU256633|EU256634|EU256635|EU256636

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atpC

Mutations

Gene Information

Gene Information