atpG

ATP synthase subunit

Validation StatusCandidate

Overview

Mechanism: Membrane potential regulation
Validation Method: E-test
Drug Classes: Gentamicin, Polymyxin b, Colistin
Organisms: Staphylococcus aureus JE2, Staphylococcus aureus
Papers: 2
Databases: Reslit

Papers2

Genome-Wide Identification of Antimicrobial Intrinsic Resistance Determinants in Staphylococcus aureus.

PMID 28066345 · 2016

The study identifies multiple intrinsic resistance determinants in Staphylococcus aureus, including genes such as atpA, rpsT, vraG, and mecA, which contribute to resistance against various antimicrobial agents. These findings highlight potential targets for developing antimicrobial potentiators.

Gene Information

Gene Name: atpG
Allele: atpG
Encodes: ATP synthase subunit
Source Database: Reslit
Mechanism: Membrane potential regulation
Confers Resistance To: Gentamicin
Organisms Tested In: • Staphylococcus aureus JE2
Validation Method: E-test

Inhibition of the ATP Synthase Eliminates the Intrinsic Resistance of Staphylococcus aureus towards Polymyxins.

PMID 28874470 · 2017

The study identifies the ATP synthase as a novel target for enhancing the efficacy of polymyxins against Staphylococcus aureus by demonstrating that inactivation of ATP synthase subunits increases susceptibility to polymyxins and colistin.

Gene Information

Gene Name: atpG
Allele: atpG
Encodes: F0F1 ATP synthase subunit gamma
Source Database: Reslit
Mechanism: intrinsic resistance
Confers Resistance To: Polymyxin bColistin
Organisms Tested In: • Staphylococcus aureus
Validation Method: transposon mutagenesis and MIC testing

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atpG

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