atpH

ATP synthase subunit

Validation StatusSupported

Overview

Mechanism: Membrane potential regulation
Validation Method: E-test
Drug Classes: Gentamicin, Polymyxin b, Colistin
Organisms: Staphylococcus aureus JE2, Staphylococcus aureus, Streptococcus mutans
Papers: 3
Databases: Reslit
Mutations: 2

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
-	G-36T	-	Streptococcus mutans	-	Reslit	Candidate
-	G36T	-	Streptococcus mutans	-	Reslit	Candidate

Papers3

Genome-Wide Identification of Antimicrobial Intrinsic Resistance Determinants in Staphylococcus aureus.

PMID 28066345 · 2016

The study identifies multiple intrinsic resistance determinants in Staphylococcus aureus, including genes such as atpA, rpsT, vraG, and mecA, which contribute to resistance against various antimicrobial agents. These findings highlight potential targets for developing antimicrobial potentiators.

Gene Information

Gene Name: atpH
Allele: atpH
Encodes: ATP synthase subunit
Source Database: Reslit
Mechanism: Membrane potential regulation
Confers Resistance To: Gentamicin
Organisms Tested In: • Staphylococcus aureus JE2
Validation Method: E-test

Inhibition of the ATP Synthase Eliminates the Intrinsic Resistance of Staphylococcus aureus towards Polymyxins.

PMID 28874470 · 2017

The study identifies the ATP synthase as a novel target for enhancing the efficacy of polymyxins against Staphylococcus aureus by demonstrating that inactivation of ATP synthase subunits increases susceptibility to polymyxins and colistin.

Gene Information

Gene Name: atpH
Allele: atpH
Encodes: F0F1 ATP synthase subunit delta
Source Database: Reslit
Mechanism: intrinsic resistance
Confers Resistance To: Polymyxin bColistin
Organisms Tested In: • Staphylococcus aureus
Validation Method: transposon mutagenesis and MIC testing

F(0)F(1)-ATPase Contributes to the Fluoride Tolerance and Cariogenicity of Streptococcus mutans.

PMID 35173687 · 2021

A novel -36G→T mutation in the promoter region of the atpH gene of F0F1-ATPase contributes to fluoride tolerance and increased cariogenicity in Streptococcus mutans.

Gene Information

Gene Name: atpH
Allele: atpH
Encodes: F0F1-ATPase subunit H
Source Database: Reslit
Mechanism: upregulation due to promoter mutation increases fluoride tolerance
Organisms Tested In: • Streptococcus mutans
Validation Method: qRT-PCR and MIC assays
Sequence Accession: SRR13846722|SRR13846723|SRR13846724

Browse AMR Genes

atpH

Mutations

Gene Information

Gene Information

Gene Information