axyZ

Overview

Drug Classes: Tobramycin|Amikacin|Gentamicin|Netilmicin|Ceftazidime|Cefepime|Imipenem|Meropenem|Doripenem|Ofloxacin|Levofloxacin|Ciprofloxacin|Tetracycline|Doxycycline|Tigecycline|Erythromycin
Organisms: Achromobacter insuavis, Achromobacter xylosoxidans
Papers: 1
Mutations: 1

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
V29G	T86G	single resistance variant, overproduction of the AxyXY-OprZ efflux system	Achromobacter insuavis, Achromobacter xylosoxidans	Tobramycin\|Amikacin\|Gentamicin\|Netilmicin\|Ceftazidime\|Cefepime\|Imipenem\|Meropenem\|Doripenem\|Ofloxacin\|Levofloxacin\|Ciprofloxacin\|Tetracycline\|Doxycycline\|Tigecycline\|Erythromycin	Card DatabaseReslit	Confirmed

Papers1

Role of AxyZ Transcriptional Regulator in Overproduction of AxyXY-OprZ Multidrug Efflux System in Achromobacter Species Mutants Selected by Tobramycin.

PMID 28584156 · 2017

AxyZ; CARD accession: CARD:3004145

The V29G mutation in AxyZ leads to overproduction of the AxyXY-OprZ efflux system, increasing resistance to multiple antibiotics.

Mutation Information

axyZ: p.V29G

Protein Change: V29G
Organisms: Achromobacter insuavis, Achromobacter xylosoxidans
Confers Resistance To: Tobramycin|Amikacin|Gentamicin|Netilmicin|Ceftazidime|Cefepime|Imipenem|Meropenem|Doripenem|Ofloxacin|Levofloxacin|Ciprofloxacin|Tetracycline|Doxycycline|Tigecycline|Erythromycin
Effect on Function: single resistance variant; overproduction of the AxyXY-OprZ efflux system
Source Database: Card DatabaseReslit

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axyZ

Mutations

Mutation Information