axyZ

transcriptional regulator

Overview

Mechanism: overproduction of the AxyXY-OprZ efflux system
Drug Classes: Tobramycin, Amikacin, Gentamicin, Netilmicin, Ceftazidime, Cefepime, Imipenem, Meropenem, Doripenem, Ofloxacin, Levofloxacin, Ciprofloxacin, Tetracycline, Doxycycline, Tigecycline, Erythromycin
Organisms: Achromobacter insuavis, Achromobacter xylosoxidans
Papers: 1
Mutations: 1

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
V29G	T86G	overproduction of the AxyXY-OprZ efflux system	Achromobacter insuavis, Achromobacter xylosoxidans	tobramycinamikacingentamicin+13 more	Reslit	Candidate

Papers1

Role of AxyZ Transcriptional Regulator in Overproduction of AxyXY-OprZ Multidrug Efflux System in Achromobacter Species Mutants Selected by Tobramycin.

Research Article

PMID 28584156 · 2017

The V29G mutation in AxyZ leads to overproduction of the AxyXY-OprZ efflux system, increasing resistance to multiple antibiotics.

Mutation Information

axyZ: p.V29G / c.T86G

Protein Change: V29G
Nucleotide Change: T86G
Organisms: Achromobacter insuavis, Achromobacter xylosoxidans
Confers Resistance To: tobramycinamikacingentamicinnetilmicinceftazidimecefepimeimipenemmeropenemdoripenemofloxacinlevofloxacinciprofloxacintetracyclinedoxycyclinetigecyclineerythromycin
Effect on Function: overproduction of the AxyXY-OprZ efflux system
Validation Method: Mutant analysis and gene expression studies
Source Database: Reslit

Protein Change

Nucleotide Change

Mechanism

Organism

Resistance To

Database

Validation Status

V29G

T86G

overproduction of the AxyXY-OprZ efflux system

Achromobacter insuavis, Achromobacter xylosoxidans

tobramycinamikacingentamicin+13 more

Reslit

Candidate

axyZ

Mutations

Mutation Information

Browse AMR Genes

axyZ

Mutations

Mutation Information