Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
bacteriocin
Overview
Bac 32, a novel bacteriocin widely disseminated among clinical isolates of Enterococcus faecium.
The study identifies Bac 32, a novel bacteriocin produced by Enterococcus faecium, which exhibits activity against E. faecium, E. hirae, and E. durans. The bacteriocin is encoded on plasmid pTI1 and includes the structural gene bacA and the immunity gene bacB.
Genetic changes that correlate with the pine-oil disinfectant-reduced susceptibility mechanism of Staphylococcus aureus.
The study identifies mutations in ccpA, adh1, and frp genes in a S. aureus PD RS mutant, which are linked to increased growth rates, upregulation of metabolic pathways, and reduced susceptibility to bacitracin and farnesol.
Virulence determinants, drug resistance and mobile genetic elements of Laribacter hongkongensis: a genome-wide analysis.
The study identifies several β-lactam resistance genes, including ampC, lacA, pbp2, pbp3, pbp4a, pbp6a, and pbp7, as well as multidrug efflux pumps such as acrAB-tolC, acrAD-tolC, mdtABC-tolC, emrAB-tolC, mexAB-oprM, and others. Additionally, genes like bacA, ksgA, crcB, and rarD are implicated in resistance to bacitracin, kasugamycin, streptomycin, camphor, and chloramphenicol, respectively.
Antimicrobial Susceptibility of Bacillus Strains Isolated from Primary Starters for African Traditional Bread Production and Characterization of the Bacitracin Operon and Bacitracin Biosynthesis.
The study identified erythromycin resistance genes ermD and ermK in Bacillus licheniformis strains and bacitracin biosynthesis genes bacA and bcrA in Bacillus sonorensis strains, highlighting species-specific antimicrobial resistance profiles.
Comparative genomics of Clostridium bolteae and Clostridium clostridioforme reveals species-specific genomic properties and numerous putative antibiotic resistance determinants.
The study identified numerous antibiotic resistance genes in Clostridium bolteae and Clostridium clostridioforme, including beta-lactamases, glycopeptide resistance operons, macrolide and lincosamide resistance genes, and efflux pumps. Notably, C. bolteae 90B3 exhibited resistance to linezolid, chloramphenicol, florfenicol, and tiamulin due to the presence of the 23S rRNA methyltransferase gene cfr. Additionally, C. clostridioforme 90A8 possessed a VanB-type operon conferring vancomycin resistance.
The complete genome sequence of Vibrio aestuarianus W-40 reveals virulence factor genes.
The study identified bacA and tet34 genes in Vibrio aestuarianus strain W-40, which confer resistance to bacitracin and tetracycline, respectively.
The Genomic Basis of Intrinsic and Acquired Antibiotic Resistance in the Genus Serratia.
The study identified 123 distinct antibiotic resistance genes (ARGs) in the genus Serratia, including intrinsic and acquired resistance genes, as well as efflux pump-related genes. Key findings include the detection of various beta-lactamases, aminoglycoside resistance genes, quinolone resistance genes, and efflux pumps. Notably, the study highlights the presence of plasmid-borne ARGs in nosocomial strains and the role of efflux pumps in multidrug resistance.
Complete Genome Sequence of Photobacterium damselae Subsp. damselae Strain SSPD1601 Isolated from Deep-Sea Cage-Cultured Sebastes schlegelii with Septic Skin Ulcer.
The study identified the bacA gene as the only antimicrobial resistance gene in PDD strain SSPD1601, which is associated with resistance to bacitracin. Despite being resistant to multiple antibiotics, no corresponding resistance genes were detected for these antibiotics.
Characterization of Discriminatory Antimicrobial Resistance Genes in Aquatic Environments Using Machine Learning
The study identifies discriminatory antibiotic resistance genes (ARGs) using an extremely randomized tree (ERT) algorithm, highlighting genes like sul1, tet(W), and ermB as significant markers for differentiating resistomes across various aquatic environments.
Comparative genomic analyses reveal diverse virulence factors and antimicrobial resistance mechanisms in clinical Elizabethkingia meningoseptica strains.
The study identified multiple antimicrobial resistance genes in Elizabethkingia meningoseptica strains, including beta-lactamases, tetracycline resistance genes, and efflux pumps, indicating a multidrug-resistant profile.
Metagenomic read cloud sequencing reveals antibiotic resistance gene dynamics in the gut microbiome of a hematopoietic cell transplant patient
The study identified 46 antibiotic resistance genes in the pre-transplant E. coli strain, including genes conferring resistance to beta-lactams, aminoglycosides, polymyxins, bacitracin, and multiple drugs through efflux pumps.
Preterm infants harbour diverse Klebsiella populations, including atypical species that encode and produce an array of antimicrobial resistance- and virulence-associated factors.
The study identified various antimicrobial resistance genes in Klebsiella isolates from preterm infants, highlighting the presence of multidrug resistance mechanisms.
Revealing antimicrobial resistance in stormwater with MinION.
The study identified several AMR genes in stormwater samples from Stockholm, including aac(3)-X, aac(6')-I, aph(3')-I, aph(3')-IIb, bacA, chloramphenicol, rosA, ermO, abeS, major facilitator superfamily transporter, mexE, mexX, ompR, opcM, oprA, oprN, qacG, puromycin, ADP-ribosylating, dfrA12, vanH, vanR, and vanS, which confer resistance to various antibiotics such as aminoglycosides, beta-lactams, chloramphenicol, fosmidomycin, MLS, multidrug, puromycin, rifamycin, trimethoprim, and vancomycin.
Isolation and characterization of Uropathogenic Escherichia coli (UPEC) from red panda (Ailurus fulgens).
The study identified a Uropathogenic Escherichia coli (UPEC) strain isolated from a red panda that exhibited resistance to multiple antibiotics, including aminoglycosides, beta-lactams, and macrolides. The strain possessed 20 resistance genes, such as acra, acrb, mdte, mdtf, mdtn, mdto, mdtp, tolc, arna, baca, bcr, bl1_ec, emre, ksga, macb, mdfa, mdtg, mdth, mdtk, and mdtl, which contribute to multidrug resistance.
Genomic Characteristics of Colistin-Resistant Salmonella enterica subsp. enterica Serovar Infantis from Poultry Farms in the Republic of Serbia.
The study identified the fosfomycin resistance gene fosA7 and the vgaA gene in Salmonella enterica subsp. enterica serovar Infantis isolates from poultry farms in Serbia. Mutations in the pmrB gene were associated with colistin resistance.
Prevalence and antimicrobial resistance profiling of Staphylococcus aureus isolated from traditional cheese in Yunnan, China.
The study identified 18 antimicrobial resistance genes in Staphylococcus aureus strain DC.RB_015, including mecA, blaZ, mepA, tet(K), tet(38), arlR, arlS, norA, mgrA, LmrS, APH(3′)-IIIa, aad(6), ErmB, SAT-4, mecR1, GlpT, murA, and bacA, which confer resistance to various antibiotics such as methicillin, beta-lactam, tetracycline, fluoroquinolone, macrolide, aminoglycoside, nucleoside, fosfomycin, and bacitracin.
Similarities in Virulence and Extended Spectrum Beta-Lactamase Gene Profiles among Cefotaxime-Resistant Escherichia coli Wastewater and Clinical Isolates.
The study identifies several beta-lactamase genes, including blaCTX-M-1, blaKPC-2, blaTEM-350, blaOXA-1, and blaCTX-M-15, as well as various aminoglycoside, macrolide, and tetracycline resistance genes in cefotaxime-resistant E. coli isolates from hospital and urban wastewater. Mutations in parC, parE, and gyrA contribute to fluoroquinolone resistance.
Spatiotemporal Investigation of Antibiotic Resistance in the Urban Water Cycle Influenced by Environmental and Anthropogenic Activity.
The study identified several AMR genes, including carbapenemases (cphA5, cphA7, imiH, ESP-1), colistin resistance gene mcr-7.1, aminoglycoside resistance genes (aadA, aph(6)-Id, aph(3')-Ib), sulfonamide/trimethoprim resistance genes (sul1, dfrA15, dfrA14), and multidrug efflux pumps (MexB, OpmH, MexK) in various bacterial isolates from urban water samples.
Genomic Characterization and Genetic Profiles of Salmonella Gallinarum Strains Isolated from Layers with Fowl Typhoid in Colombia.
The study identified 26 chromosomal resistance genes in Salmonella Gallinarum strains, primarily encoding efflux pumps, and point mutations in gyrase genes (gyrA and gyrB) associated with quinolone resistance. The gyrB mutation S464T was frequently found in Colombian strains.
Antibacterial and Biofilm Production Inhibition Activity of Thymus vulgaris L. Essential Oil against Salmonella spp. Isolates from Reptiles.
The study identified several AMR genes in Salmonella spp. isolates from reptiles, including genes encoding multidrug efflux pumps, aminoglycoside resistance, bacitracin resistance, and fosfomycin resistance. Despite the presence of these genes, all isolates were susceptible to tested antibiotics.
Distribution and relationship of antibiotics, heavy metals and resistance genes in the upstream of Hanjiang River Basin in Shiyan, China.
The study identified bacA and arsT genes as the most abundant antibiotic resistance genes (ARGs) and metal resistance genes (MRGs) in the study area, conferring resistance to bacitracin and arsenic, respectively.
Social demographics determinants for resistome and microbiome variation of a multiethnic community in Southern Malaysia.
The study identified 1038 antibiotic resistance genes from 200 community participants, highlighting the association of resistome profiles with lifestyle and environmental factors, particularly emphasizing the role of Escherichia coli in the resistome dynamics.
Antipsychotic quetiapine alters the mouse fecal resistome by impacting antibiotic efflux, cell membrane, and cell wall synthesis genes.
Quetiapine exposure increased the relative abundance of AMR gene families related to antibiotic efflux, cell membrane, and cell wall synthesis in the mouse fecal resistome, leading to reduced colistin susceptibility in Escherichia species.
In Vitro Microevolution and Co-Selection Assessment of Florfenicol Impact on Escherichia coli Resistance Development.
Florfenicol exposure leads to increased resistance to fluoroquinolones and cephalosporins through mutations in efflux pump genes such as acrB, acrR, emrR, and robA, as well as the presence of resistance genes like ampC, ampH, bacA, and emrB.
Bacterial diversity and resistome analysis of drinking water stored in cisterns from two First Nations communities in Manitoba, Canada.
The study identified a diverse array of antimicrobial resistance genes in drinking water stored in cisterns from two First Nations communities in Manitoba, Canada. Key findings include the presence of genes such as aac(3')-Ia, aac(6')-Iia, aac(6')-Iic, aph(3')-Ia, acrD, smeB, smeR, FEZ-1, rm3, SPG-1, OXA-21, OXA-119, OXA-205, dfrA14, dfrB6, acrB, acrF, adeF, ceoB, emrA, mexE, mexF, mexI, oprN, oqxB, BRP(MBL), vanSO, axyY, CRP, efrB, macB, mexB, mexC, mexD, mexK, mexQ, mexW, mexY, mtrA, muxB, muxC, oleB, oleC, ompB, oprM, smeD, smeE, golS, mdsB, PER-2, TEM-126, msbA, arnA, bacA, bcrA, MCR-5, rosA, rosB, rpoB2, ugd, mexN, taeA, efpA, rphA, rphB, otr(A), otrC, tetA(48 ), ompH, and triC, which confer resistance to various antibiotics including aminoglycosides, beta-lactams, cephalosporins, carbapenems, fluoroquinolones, macrolides, monobactams, nitroimidazoles, peptides, phenicols, pleuromutilins, rifamycins, tetracyclines, and triclosan.
Genome mining of Escherichia coli WG5D from drinking water source: unraveling antibiotic resistance genes, virulence factors, and pathogenicity.
The study identifies multiple antibiotic resistance genes in E. coli WG5D, including multidrug efflux pumps and genes conferring resistance to various antibiotics such as fluoroquinolones, cephalosporins, and glycopeptides.
Causal-ARG: A Causal Representation Learning Framework for Annotating Antimicrobial Resistance Genes
The paper proposes a causality-guided framework called Causal-ARG for annotating properties of antibiotic resistance genes (ARGs), focusing on antibiotic class, resistance mechanism, and transferability.
A novel pathogenic species of genus Stenotrophomonas: Stenotrophomonas pigmentata sp. nov.
The study identifies a novel pathogenic species, Stenotrophomonas pigmentata sp. nov., which exhibits resistance to multiple antibiotics, including β-lactams, carbapenems, and trimethoprim-sulfamethoxazole. Several multidrug resistance efflux pump and antibiotic resistance genes were found in its genome.
Treatment of antibiotic-manufacturing wastewater enriches for Aeromonas veronii, a zoonotic antibiotic-resistant emerging pathogen.
The study identifies the beta-lactamase gene OXA-12 and the bacitracin resistance gene bacA in Aeromonas veronii, which was enriched in an antibiotic-manufacturing wastewater treatment plant. These genes contribute to the antibiotic resistance of A. veronii, highlighting its potential as a zoonotic pathogen.
Distribution status and influencing factors of antibiotic resistance genes in the Chaohu Lake, China.
The study identified nine families of antibiotic resistance genes (ARGs) in Chaohu Lake, with multidrug, bacitracin, polymyxin, macrolide lincosamide streptogramin (MLS), and aminoglycoside being the most abundant. Key genes included bacA, mexF, and mdtB, which were found to confer resistance to specific antibiotics.
Next generation antimicrobial peptide disinfectant targeting biocide and vancomycin resistant staphylococcus aureus through integrated in Silico and in vitro validation.
The study identifies bacitracin B1 (UB1) as a potent antimicrobial compound produced by Bacillus paralicheniformis UAB33, effective against biocide-resistant VRSA. The bacitracin biosynthetic gene cluster (bacA, bacB, bacC) was characterized, and the compound showed strong bactericidal activity and antibiofilm effects.
Genomic insights into Shigella species isolated from small ruminants and manure in the North West Province, South Africa.
The study identified multiple antibiotic resistance genes in Shigella species isolated from small ruminants and manure in South Africa, highlighting the presence of multidrug-resistant strains and the diversity of resistance mechanisms.
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