Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
response regulator of a two-component system
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| S40N | - | - | Acinetobacter baumannii | Tigecycline | Reslit | Candidate |
| S104N | - | envelope stress response regulator BaeR, single resistance variant | Acinetobacter baumannii, Enterobacter cloacae | CEFIDEROCOL | Card DatabaseReference Gene Catalog | Confirmed |
| G23E | - | envelope stress response regulator BaeR |
AZTREONAM-AVIBACTAM |
Reference Gene Catalog |
| Established |
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| baeR | Reslit | 12 | Oxacillin, Cloxacillin +8 | Salmonella enterica serovar Typhimurium +4 | China, Europe, South Africa, Bangladesh, India | 2007, 2014, 2015, 2018, 2021, 2022, 2023, 2024, 2025 | MH697720|MH697721|MH697722|MH697723|MH697724|MH697725|MH697726|MH697727|MH697728 | - |
| BaeR | Reslit | 1 | Cefiderocol | Acinetobacter baumannii | - | 2023 | - | - |
| bae R | Reslit | 1 | Carbapenem | Acinetobacter baumannii | - | 2024 | MK344183.1|MK344168.1 | - |
Regulation of multidrug efflux systems involved in multidrug and metal resistance of Salmonella enterica serovar Typhimurium.
The study identifies baeR as a gene that, when overexpressed, increases resistance to multiple antibiotics including oxacillin, cloxacillin, nafcillin, novobiocin, and deoxycholate in Salmonella enterica serovar Typhimurium.
Role of the BaeSR two-component system in the regulation of Acinetobacter baumannii adeAB genes and its correlation with tigecycline susceptibility.
The BaeSR two-component system regulates the expression of the AdeAB efflux pump genes in Acinetobacter baumannii, thereby influencing tigecycline susceptibility.
The Role of the Two-Component System BaeSR in Disposing Chemicals through Regulating Transporter Systems in Acinetobacter baumannii.
The study identifies that the BaeSR two-component system regulates the expression of efflux pump genes adeA, adeB, adeI, adeJ, adeK, macA, macB, and tolC in Acinetobacter baumannii, contributing to tigecycline resistance. Deletion of baeR reduces the expression of these genes, leading to increased susceptibility to tannic acid and tigecycline.
Mode of Action of the Monobactam LYS228 and Mechanisms Decreasing In Vitro Susceptibility in Escherichia coli and Klebsiella pneumoniae.
The study identifies mutations in baeS, cpxA, ftsI, and baeR that decrease susceptibility to LYS228 in Escherichia coli and Klebsiella pneumoniae. These mutations are linked to efflux pump activation and target modification, contributing to reduced antibiotic effectiveness.
Metagenomic read cloud sequencing reveals antibiotic resistance gene dynamics in the gut microbiome of a hematopoietic cell transplant patient
The study identified 46 antibiotic resistance genes in the pre-transplant E. coli strain, including genes conferring resistance to beta-lactams, aminoglycosides, polymyxins, bacitracin, and multiple drugs through efflux pumps.
Molecular Epidemiological Analysis of ST11-K64 Extensively Drug-Resistant Klebsiella pneumoniae Infections Outbreak in Intensive Care and Neurosurgery Units Based on Whole-Genome Sequencing.
The study identified multiple AMR genes in ST11-K64 XDRKp strains, including beta-lactamases, aminoglycoside resistance genes, and efflux pumps, contributing to extensive drug resistance.
Genomic and Phenotypic Evolution of Tigecycline-Resistant Acinetobacter baumannii in Critically Ill Patients.
The study identifies several genes and mutations associated with tigecycline resistance in Acinetobacter baumannii, including baeR, wzc, aroQ, rluC, adeS, and IS Aba1. These genetic elements contribute to the development of tigecycline resistance in clinical isolates from critically ill patients.
Dynamics of Microbial Community and Potential Microbial Pollutants in Shopping Malls.
The study identified several antimicrobial resistance genes, including CRP, ACT-1, baeR, acrA, H-NS, and oqxB, in Enterobacteriaceae isolates from shopping mall surfaces, highlighting the presence of multidrug efflux systems and antibiotic target alterations as key resistance mechanisms.
Mutation in the two-component regulator BaeSR mediates cefiderocol resistance and enhances virulence in Acinetobacter baumannii.
Mutations in the two-component regulator BaeSR (D89V in BaeS and S104N in BaeR) mediate cefiderocol resistance in Acinetobacter baumannii by up-regulating efflux pump genes, particularly MFS transporters and MacAB-TolC. Additionally, the BaeS mutation increases virulence by up-regulating the paa operon.
Cefiderocol and Sulbactam-Durlobactam against Carbapenem-Resistant Acinetobacter baumannii.
The study characterizes several AMR genes and mutations involved in resistance to cefiderocol in Acinetobacter baumannii, including blaPER-1, blaNDM-1, blaADC-25, blaADC-33, pirA, piuA, BaeS, BaeR, and specific mutations in PirA and PBP3.
Genome mining of Escherichia coli WG5D from drinking water source: unraveling antibiotic resistance genes, virulence factors, and pathogenicity.
The study identifies multiple antibiotic resistance genes in E. coli WG5D, including multidrug efflux pumps and genes conferring resistance to various antibiotics such as fluoroquinolones, cephalosporins, and glycopeptides.
Based on molecular docking and real-time PCR technology, the two-component system Bae SR was investigated on the mechanism of drug resistance in CRAB.
The two-component system Bae SR was found to play a critical role in carbapenem resistance in CRAB, with increased expression of bae S and bae R genes correlating with higher resistance levels.
Genomic Characterization of Pan-Drug Resistant Klebsiella pneumoniae KPNW Isolated From UTI Patient in Bangladesh.
The study identifies 42 antimicrobial resistance (AMR) genes in the pan-drug resistant Klebsiella pneumoniae isolate KPNW, including beta-lactamases (bla CTX-M-15, bla NDM-1, bla OXA-1, bla TEM-63, bla TEM-104, bla SHV-28), tetracycline resistance genes (tet(A)), and efflux pump genes (oqxA, oqxB, marA, marR, ompK37, pbp3, crp, h-ns, kpnG, kpnH, parC, rsmA). Additionally, the isolate shows resistance to polymyxin B and colistin through modifications in lipid A (eptB, arnT, lptD, msbA, vanG) and other mechanisms.
Genomic insights into novel ST7947 carbapenem-resistant hypervirulent Klebsiella pneumoniae: a threat from an Indian hospital setting.
The study identifies several AMR genes and mutations in the novel ST7947 carbapenem-resistant hypervirulent Klebsiella pneumoniae isolate BB-7, including bla CTX-M-15, bla SHV-28, bla TEM-1, bla OXA-1, bla OXA-232, armA, aadA2, baeR, tetD, adeF, emrR, AAC(6')-Ib-cr6, catI, sul1, mphE, msrE, dfrA1, oqxA, and fosA, as well as mutations in GyrA, ParC, OmpA, OmpK37, and ArnT that confer resistance to multiple antibiotics.
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