Browse AMR Genes

Explore antimicrobial resistance genes from the literature

ResLit

basR

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to basR

AMR Rules

Browse AMR rules for basR

Overview

Drug Classes: Colistin, COLISTIN
Organisms: Pseudomonas aeruginosa, E. coli, Escherichia coli
Papers: 6
Mutations: 15

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
L71R	-	single resistance variant	Pseudomonas aeruginosa	Colistin	Card DatabaseReslit	Confirmed
G53E	-	two-component system response regulator BasR	E. coli, Escherichia coli	ColistinCOLISTIN	Reference Gene CatalogReslit	Confirmed

Papers6

The genomic configurations driving antimicrobial resistance and virulence in colistin resistant Pseudomonas aeruginosa from an Egyptian Tertiary Oncology Hospital.

PMID 40763289 · 2025

Mutation Information

basR: p.L71R

Protein Change: L71R
Organisms: Pseudomonas aeruginosa
Confers Resistance To: Colistin
Source Database: Reslit

CRISPR-FRT targets shared sites in a knock-out collection for off-the-shelf genome editing.

PMID 29884781 · 2018

Mutation Information

basR: p.G53E

Protein Change: G53E
Organisms: E. coli
Confers Resistance To: Colistin
Source Database: Reslit

Colistin resistance in Parisian inpatient faecal Escherichia coli as the result of two distinct evolutionary pathways.

PMID 30863849 · 2019

basR

Mutation Information

basR: p.G15R basR: p.G53C basR: p.G53S basR: p.S39I basR: p.G53E basR: p.G53V basR: p.R81L basR: p.G53A basR: p.G53R basR: p.G53W basR: p.R81S

Protein Change: G15R, G53C, G53S, S39I, G53E, G53V, R81L, G53A, G53R, G53W, R81S
Organisms: Escherichia coli
Confers Resistance To: COLISTIN
Effect on Function: two-component system response regulator BasR
Source Database: Reference Gene Catalog

Small Molecule Adjuvants Potentiate Colistin Activity and Attenuate Resistance Development in Escherichia coli by Affecting pmrAB System.

PMID 32764996 · 2020

basR

Mutation Information

basR: p.A80V

Protein Change: A80V
Organisms: Escherichia coli
Confers Resistance To: COLISTIN
Effect on Function: two-component system response regulator BasR
Source Database: Reference Gene Catalog

Contribution of Novel Amino Acid Alterations in PmrA or PmrB to Colistin Resistance in mcr-Negative Escherichia coli Clinical Isolates, Including Major Multidrug-Resistant Lineages O25b:H4-ST131-H30Rx and Non-x.

PMID 29914952 · 2018

basR

Mutation Information

basR: p.L105P

Protein Change: L105P
Organisms: Escherichia coli
Confers Resistance To: COLISTIN
Effect on Function: two-component system response regulator BasR
Source Database: Reference Gene Catalog

Mutations and expression of PmrAB and PhoPQ related with colistin resistance in Pseudomonas aeruginosa clinical isolates.

PMID 24412662 · 2014

basR; CARD accession: CARD:3003582

Mutation Information

basR: p.L157Q basR: p.L71R

Protein Change: L157Q, L71R
Organisms: Pseudomonas aeruginosa
Effect on Function: single resistance variant
Source Database: Card Database