Browse AMR Genes

Explore antimicrobial resistance genes from the literature

ResLit

bcrR

novel regulatory protein

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to bcrR

AMR Rules

Browse AMR rules for bcrR

Validation StatusSupported

Overview

Mechanism: activates the expression of bcrABD genes
Validation Method: mutagenesis and complementation studies
Drug Classes: Bacitracin
Organisms: Enterococcus faecalis, Enterococcus spp., Clostridium perfringens, Enterococcus hirae R17, Enterococcus faecium
Geographic Location: China, New Zealand, Quebec, Canada, United States|Europe|China|South Korea|Egypt
Alleles: 2
Papers: 7
Databases: Reslit

Allele Variants2

Allele	Database	Papers	Drug Classes	Organisms	Countries	Years	Sequence Accession	Protein Accession
bcrR	Reslit	6	Bacitracin	Enterococcus faecalis +3	New Zealand, China, United States\|Europe\|China\|South Korea\|Egypt	2004, 2008, 2017, 2019, 2023	AY496968	-
bcrr	Reslit

Papers7

Acquired bacitracin resistance in Enterococcus faecalis is mediated by an ABC transporter and a novel regulatory protein, BcrR.

PMID 15388429 · 2004

The study identifies the bcrABD operon and the regulatory gene bcrR as essential for acquired bacitracin resistance in Enterococcus faecalis. The bcrABD genes encode a homodimeric ABC transporter that mediates bacitracin efflux, and bcrR acts as a transcriptional activator of this operon.

Gene Information

Gene Name: bcrR
Allele: bcrR
Encodes: novel regulatory protein
Source Database: Reslit
Mechanism: activates the expression of bcrABD genes
Confers Resistance To: Bacitracin
Organisms Tested In: • Enterococcus faecalis
Geographic Location: New Zealand
Validation Method: mutagenesis and complementation studies
Sequence Accession: AY496968

Antibiotic resistance in Escherichia coli and Enterococcus spp. isolates from commercial broiler chickens receiving growth-promoting doses of bacitracin or virginiamycin.

PMID 18505201 · 2008

The study identified the presence of bacitracin resistance gene bcrR, virginiamycin resistance genes vatD and ermB in Enterococcus spp. isolates from broiler chickens.

Gene Information

Gene Name: bcrR
Allele: bcrR
Encodes: resistance gene
Source Database: Reslit
Confers Resistance To: Bacitracin
Organisms Tested In: • Enterococcus spp.
Validation Method: PCR and phenotypic resistance testing

Characterization of genes encoding for acquired bacitracin resistance in Clostridium perfringens.

PMID 22970221 · 2012

The study identifies and characterizes the bcrABDR operon in Clostridium perfringens, which includes genes encoding an ABC transporter (bcrA, bcrB), an undecaprenol kinase (bcrD), and a regulatory gene (bcrR) associated with high-level bacitracin resistance.

Gene Information

Gene Name: bcrR
Allele: bcrr
Encodes: regulatory protein
Source Database: Reslit
Confers Resistance To: Bacitracin
Organisms Tested In: • Clostridium perfringens
Geographic Location: Quebec, Canada
Validation Method: sequencing and PCR
Sequence Accession: GU810179|GU810180|GU810181|GU810182

Characterization of Multi-Drug Resistant Enterococcus faecalis Isolated from Cephalic Recording Chambers in Research Macaques (Macaca spp.).

PMID 28081148 · 2017

The study identified various AMR genes and mutations in Enterococcus faecalis isolates from macaque cephalic implants, highlighting the presence of high-level aminoglycoside resistance, tetracycline resistance, and bacitracin resistance. These findings emphasize the complexity of AMR in clinical settings and the need for targeted antimicrobial strategies.

Gene Information

Gene Name: bcrR
Allele: bcrR
Encodes: transcriptional regulator
Source Database: Reslit
Confers Resistance To: Bacitracin
Organisms Tested In: • Enterococcus faecalis
Validation Method: whole genome sequencing
Sequence Accession: MCFU01000001-MCFU01000003|MCFV01000001-MCFV01000003|MCFW01000001-MCFW01000002

Genomic insights into the pathogenicity and environmental adaptability of Enterococcus hirae R17 isolated from pork offered for retail sale.

PMID 28799224 · 2017

The study identified multiple antimicrobial resistance genes in Enterococcus hirae R17, including genes conferring resistance to beta-lactam antibiotics, lincosamides, streptogramins, pleuromutilins, polymyxins, tetracyclines, and others. Notably, the strain exhibited resistance to bacitracin, ciprofloxacin, daptomycin, erythromycin, and tetracycline.

Gene Information

Gene Name: bcrR
Allele: bcrR
Encodes: bacitracin-related transcriptional regulator
Source Database: Reslit
Confers Resistance To: Bacitracin
Organisms Tested In: • Enterococcus hirae R17
Geographic Location: China
Validation Method: genome analysis
Sequence Accession: CP015516|CP015517

Agricultural Origins of a Highly Persistent Lineage of Vancomycin-Resistant Enterococcus faecalis in New Zealand.

PMID 31028029 · 2019

The study identifies the ST108 lineage of vancomycin-resistant Enterococcus faecalis as having an agricultural origin, with multiple resistance genes including vanA, ermB, tetL, tetM, and bcr operon components contributing to its persistence in New Zealand.

Gene Information

Gene Name: bcrR
Allele: bcrR
Encodes: response regulator
Source Database: Reslit
Confers Resistance To: Bacitracin
Organisms Tested In: • Enterococcus faecalis
Geographic Location: New Zealand
Validation Method: PCR and MIC testing
Sequence Accession: NCBI RefSeq NZ_CP018065

Antimicrobial resistance in poultry: mechanisms, implications, and alternatives

PMID 36514172 · 2023

The study discusses various antimicrobial resistance mechanisms in poultry, focusing on genes like bcrR associated with bambermycin resistance in Enterococcus faecium.

Gene Information

Gene Name: bcrR
Allele: bcrR
Encodes: membrane-bound one-component system
Source Database: Reslit
Mechanism: resistance to bambermycin
Organisms Tested In: • Enterococcus faecium
Geographic Location: United States|Europe|China|South Korea|Egypt
Validation Method: experimental validation