besC

outer membrane channel-forming protein

Validation StatusCandidate

Overview

Validation Method: in vitro antibiotic susceptibility testing
Drug Classes: Tetracycline, Penicillin, Carbenicillin, Azithromycin, Cefotaxime, Ethidium bromide
Organisms: Borrelia burgdorferi
Papers: 1
Databases: Reslit

Papers1

An RND-type efflux system in Borrelia burgdorferi is involved in virulence and resistance to antimicrobial compounds.

PMID 18389081 · 2008

The study identifies BesC, an outer membrane channel-forming protein in Borrelia burgdorferi, as part of an RND-type efflux system involved in antibiotic resistance and virulence. Inactivation of besC significantly reduced antibiotic resistance and prevented infection in mice.

Gene Information

Gene Name: besC
Allele: besC
Encodes: outer membrane channel-forming protein
Source Database: Reslit
Confers Resistance To: TetracyclinePenicillinCarbenicillinAzithromycinCefotaximeEthidium bromide
Organisms Tested In: • Borrelia burgdorferi
Validation Method: in vitro antibiotic susceptibility testing

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besC

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