Mutation Information

Protein Change

D75A, Q116A, K194A, W117A, K201A, K215A, E50A, Q26A, R212A

Organisms

Klebsiella pneumoniae, Acinetobacter baumannii

Confers Resistance To

Polymyxin

Effect on Function

The D75A mutation disrupts SAM binding and reduces enzymatic activity, indicating a critical role in BioC function.; The Q116A mutation disrupts the neutralization of the malonyl group, affecting substrate binding and enzymatic activity.; The K194A mutation affects the interaction with the ACP carrier, reducing enzymatic activity.; The W117A mutation disrupts SAM binding and reduces enzymatic activity, indicating a critical role in BioC function.; The K201A mutation affects the interaction with the ACP carrier, reducing enzymatic activity.; The K215A mutation affects the interaction with the ACP carrier, reducing enzymatic activity.; The E50A mutation disrupts SAM binding and reduces enzymatic activity, indicating a critical role in BioC function.; The Q26A mutation disrupts the neutralization of the malonyl group, affecting substrate binding and enzymatic activity.; The R212A mutation affects the interaction with the ACP carrier, reducing enzymatic activity.

Source Database

Reslit