birA

biotin protein ligase

Validation StatusCandidate

Overview

Validation Method: genetic studies and susceptibility testing
Organisms: Mycobacterium tuberculosis, Mycobacterium smegmatis, Staphylococcus aureus
Papers: 2
Databases: Reslit

Papers2

Bisubstrate adenylation inhibitors of biotin protein ligase from Mycobacterium tuberculosis.

PMID 22118677 · 2011

The study identifies the essentiality of the birA gene encoding biotin protein ligase (Mt BPL) in Mycobacterium tuberculosis and Mycobacterium smegmatis, and characterizes a bisubstrate inhibitor, Bio-AMS, that effectively targets Mt BPL, showing potent antitubercular activity against drug-resistant strains.

Gene Information

Gene Name: birA
Allele: birA
Encodes: biotin protein ligase
Source Database: Reslit
Organisms Tested In: • Mycobacterium tuberculosis
• Mycobacterium smegmatis
Validation Method: genetic studies and susceptibility testing

Advanced Resistance Studies Identify Two Discrete Mechanisms in Staphylococcus aureus to Overcome Antibacterial Compounds that Target Biotin Protein Ligase.

PMID 32268615 · 2020

Two resistance mechanisms to BASA were identified in S. aureus: deletion of pc and a missense mutation in bpl (D200E). The low spontaneous resistance rate suggests BPL is a promising antibacterial target.

Gene Information

Gene Name: birA
Allele: birA
Encodes: biotin protein ligase
Source Database: Reslit
Organisms Tested In: • Staphylococcus aureus
Validation Method: whole-genome sequencing and functional assays
Sequence Accession: SAMN14388873|SAMN14388874|SAMN14388875|SAMN14388876|SAMN14388877|SAMN14388878|SAMN14388879|SAMN14388880

Comments (0)

No comments yet. Be the first to comment!

Browse AMR Genes

birA

Gene Information

Gene Information