The study found that beta-lactamase-producing oral anaerobic gram-negative species were prevalent in infants, with increasing prevalence with age. Exposure to antimicrobial agents was significantly associated with higher levels of beta-lactamase-producing species.

The RAISE method was used to generate random insertion and deletion mutations in the TEM beta-lactamase gene, resulting in improved antibiotic resistance against ceftazidime.

The study identified two antibiotic resistance mechanisms: a beta-lactamase (bla) conferring resistance to ampicillin and a spectinomycin adenyltransferase (aad(9)) conferring resistance to spectinomycin. These genes were experimentally validated in E. coli.

The study characterizes the mononuclear Zn(II)-containing metallo-beta-lactamase ImiS from Aeromonas sobria, highlighting its role in carbapenem resistance through catalytic mechanisms involving Zn(II) and substrate interactions.

The study found that 74.4% of S. aureus isolates produced beta-lactamase, contributing to resistance against penicillins. Additionally, 71.1% of isolates showed resistance to oxacillin, and 47.1% to erythromycin.

The study identified aadA, aadB, and bla genes in class 1 integrons of Salmonella isolates, which conferred resistance to streptomycin, spectinomycin, gentamicin, kanamycin, and ampicillin.

The study demonstrates the use of TriNEx to generate diverse TEM-1 beta-lactamase variants with improved activity against ceftazidime and resistance to clavulanate through targeted mutagenesis.

The study identified that the isolated strain of Bacillus anthracis was susceptible to tetracycline, ciprofloxacin, and ampicillin. No AMR genes or mutations were found in the strain.

The study developed and validated a real-time PCR assay (PPNG-PCR2) for the detection of penicillinase-producing Neisseria gonorrhoeae (PPNG) in noncultured clinical samples, providing 100% sensitivity and 98.7% specificity compared to bacterial culture results.

The study identified that beta-lactamase production by Haemophilus influenzae provides passive protection to Streptococcus pneumoniae against amoxicillin, highlighting two distinct mechanisms: beta-lactamase production and biofilm formation.

The study identifies a novel linear megaplasmid carrying a beta-lactamase gene in neurotoxigenic Clostridium butyricum type E strains, highlighting the potential role of these megaplasmids in antibiotic resistance.

The study identifies the pantocin A biosynthesis gene cluster (paaPABC) and a beta-lactamase (Bla) on plasmid pPag3 in Pantoea vagans C9-1, which contribute to its biocontrol properties and resistance to ampicillin.

The study shows that the plasmidic qnrA3 gene enhances the fitness of Escherichia coli in the absence of antibiotic exposure, indicating a potential regulatory role of qnr genes beyond direct antibiotic resistance.

The study identifies phenotypic switches, which are gene fusions that confer maltose-dependent resistance to ampicillin. These fusions do not require allosteric regulation but instead rely on increased protein accumulation in the presence of maltose.

The study shows that the IcsA autotransporter passenger domain enhances the surface expression of fusion proteins, including TEM-1 beta-lactamase (Bla), leading to increased ampicillin resistance in E. coli K-12 UT5600.

The study identifies circularly permuted variants of TEM-1 beta-lactamase, CFX011 and CFX019, which confer increased resistance to cefotaxime but decreased resistance to other β-lactam antibiotics.

The study characterizes the binding of ampicillin, carbenicillin, and ertapenem in the OmpF porin and identifies mutations in ompF that increase susceptibility to these antibiotics.

The study identified the presence of ESBL-producing bacteria in urban surface waters in Malaysia, with a high occurrence of CTX-M and TEM genes.

The study identified beta-lactamase-producing Staphylococcus aureus and coagulase-negative staphylococci (CoNS) with plasmid-mediated resistance to multiple antibiotics, including methicillin and fluoroquinolones.

The study identified the prevalence of AmpC beta-lactamase and ESBL-producing Gram-negative bacilli in hospitalized patients, highlighting the need for strict antibiotic policies to prevent resistance spread.

The study identified the presence of antibiotic resistance genes aadA, tetA, and bla in E. coli isolates from the Kat River and Fort Beaufort abstraction water, indicating resistance to streptomycin, tetracycline, and beta-lactam antibiotics.

The study found that methicillin-resistant Staphylococcus aureus (MRSA) exhibited high resistance to oxacillin (96%) and arbekacin, indicating the presence of drug-resistant opportunistic microorganisms in the oral cavity of elderly patients after oral cancer treatment.

The study identifies multiple AMR genes and mutations in the multi-resistant P. aeruginosa isolate PA49, including aac(6')-Ib, aadB, blaVIM-2, ampC, and mutations in gyrA, parC, and oprD, which confer resistance to various antibiotics.

The study identified ampicillin and kanamycin resistance genes from a metagenomic library of food fermenting microbiota, specifically bla from Streptococcus salivarius subsp. thermophilus and rmtB from Lactobacillus helveticus.

The study identifies plasmid pEMB1, which contains a beta-lactamase gene (bla) that confers ampicillin resistance. The plasmid also harbors a toxin-antitoxin system (parD and parE) that enhances plasmid stability in the absence of ampicillin.

The study identifies multiple antimicrobial resistance genes in a metronidazole- and carbapenem-resistant Bacteroides thetaiotaomicron isolate, including nimD, cat, tetX, tetQ, ermF, and a novel beta-lactamase gene.

The study presents a large-scale bla Finder method capable of detecting almost all clinically available beta-lactamase genes with high specificity and sensitivity.

Compound 3, a β-lactam derivative, exhibited effective antibacterial activity against Enterococcus faecalis, including resistant strains, and showed potential for use in dentistry.

The study identifies bisthiazolidines (BTZs) as cross-class inhibitors of metallo-β-lactamases (MBLs), demonstrating their ability to inhibit all three MBL subclasses (B1, B2, and B3) through multiple binding modes.

The complete genome sequence of Bacillus sp. VT 712 reveals several antibiotic resistance genes, including those encoding resistance to vancomycin (vanZ, vanB, vanW), tetracycline (tet(A)), fosfomycin (fosB), multidrug resistance efflux pumps (including acrB), beta-lactamases, and the quaternary ammonium compound resistance protein sugE.

Ceftazidime/avibactam is effective against resistant gram-negative pathogens, including those producing extended-spectrum beta-lactamases and KPC enzymes.

The study found that α-mangostin inhibits beta-lactamase activity, enhancing the effectiveness of oxacillin against oxacillin-resistant Staphylococcus saprophyticus.

The study evaluates computational methods for predicting antimicrobial resistance profiles from whole genome sequence data, highlighting the importance of beta-lactamases and qnr genes in resistance mechanisms.

The study identified the presence of beta-lactamase production and polymyxin resistance mechanisms in Pseudomonas aeruginosa populations evolved in an artificial sputum model, contributing to antibiotic resistance.

The study characterizes the evolution of plasmid-borne antibiotic resistance genes, focusing on the chloramphenicol resistance gene (cat) and the ampicillin resistance gene (bla). It identifies mutations in the plasmid that contribute to resistance and highlights the role of clonal interference in plasmid evolution.

The study demonstrates that the combination of OP0595 and cefepime is effective against extended-spectrum-beta-lactamase-producing Klebsiella pneumoniae in a mouse model of pneumonia.

Carbadox induces phage gene transcription and affects the expression of antibiotic resistance genes in the swine gut microbiome, including aminoglycoside acetyltransferase (aac3), class A beta-lactamase (bla), and ATP-binding cassette (ABC) efflux pumps.

The study identifies several AMR genes and mutations in Corynebacterium striatum, including bla, erm(X), erm(B), aph(3')-Ic, aac(3)-XI, aph(3'')-Ib, and aph(6)-Id, along with gyrA mutations contributing to fluoroquinolone resistance.

The study identified the beta-lactamase gene blaTEM-171 and the tetracycline resistance gene tet(A) in the multidrug-resistant coliform strain COL1, which were validated through plasmid transformation and antibiotic susceptibility testing.

The study identifies and characterizes a set of boronic acid derivatives that inhibit clinically relevant beta-lactamases, including AmpC, ESBLs, KPC-2, NDM-1, and VIM-2, demonstrating their potential as diagnostic tools for detecting beta-lactamase production in clinical isolates.

The study explores the complex resistomes of Paenibacillaceae, revealing diverse antibiotic resistance mechanisms including intrinsic and acquired resistance genes such as aadD2, vanA, vanB, vanC, vanD, vanE, vanF, vanG, mcr, bla, tet, qnr, erm, mph, lnu, lsa, vat, vgb, cat, cfr, optrA, poxtA, sul, dfr, mexAB-OprM, acrAB-TolC, and oqxAB.

The study identifies the plasmid pSEA1 and the integrative element Tn 6283, which carry various antibiotic resistance genes including tet(M), mef(C), mph(G), sul2, catII, and bla, facilitating the spread of antibiotic resistance in aquatic environments.

The study identified bla_IMI-2 and bla_L1 as carbapenemase genes in carbapenem-resistant bacteria from water bodies in the Los Angeles area, highlighting the presence of these resistance mechanisms in environmental samples.

The study reports the draft genome of a multidrug-resistant Corynebacterium striatum isolate, identifying several resistance genes including tetA, tetB, vanW, ermX, aph(3')-Ia, strA-strB, bla, and cmx, along with a mutation in the gyrA gene contributing to quinolone resistance.

The study reports the cloning and overexpression of the bla gene encoding an extracellular beta-lactamase from Streptomyces albus G in Streptomyces lividans, demonstrating increased production of the enzyme compared to the original strain.

The study compared various plasmid extraction methods to identify those that effectively recover antibiotic resistance plasmids from complex broiler cecal samples. The exogenous plasmid isolation method was found to be the most consistent and reliable for obtaining a wide range of resistance plasmids.

The study identified that the plasmid pUUH239.2, which carries a beta-lactamase gene, enhances conjugation frequency in non-growing E. coli cultures under specific physicochemical conditions, particularly in 9.1 mM NaCl with Cefotaxime.

The study identified beta-lactamase activity in various bacterial strains, indicating resistance to multiple beta-lactam antibiotics.

The study identified several AMR genes in feedlot lactobacilli, including ermB, tet(S), aadA, ant(6), bla, and aph(3''-III), which confer resistance to erythromycin, tetracycline, streptomycin, kanamycin, and ampicillin. These genes were detected through PCR analysis and correlate with phenotypic resistance in some strains.

A novel strain of Sellimonas intestinalis was isolated and found to be resistant to metronidazole and imipenem.

The study identifies multiple antibiotic resistance genes in Achromobacter xylosoxidans BHW-15, including beta-lactamases, aminoglycoside-modifying enzymes, and efflux pumps, contributing to resistance against beta-lactams, aminoglycosides, and other antibiotics.

The study describes a genetic selection strategy for isolating phospho-specific designed ankyrin repeat proteins (DARPins) by linking in vivo affinity capture of a phosphorylated target protein with antibiotic resistance of Escherichia coli cells. The study shows that the beta-lactamase gene (bla) was used as a selectable reporter for transport to the periplasm, leading to resistance against beta-lactam antibiotics.

The study identified several antibiotic resistance genes in Arcobacter butzleri strains isolated from shellfish, including genes conferring resistance to beta-lactams, polymyxin, chloramphenicol, tetracycline, and macrolides.

Relebactam inhibits class A beta-lactamases, including CTX-M-15, L2, KPC-2, KPC-3, and KPC-4, but is less potent than avibactam. It restores imipenem susceptibility in KPC-producing K. pneumoniae but is less effective against S. maltophilia.

The study identifies a beta-lactamase-expressing E. coli strain that degrades ceftriaxone sodium, contributing to antibiotic resistance in a mutualistic bacterial community.

PNGM-1 is a novel subclass B3 metallo-β-lactamase with dual activity, exhibiting both β-lactamase and tRNase Z activity. It is hypothesized to have evolved from a tRNase Z.

The study characterizes PsEstA, a novel family VIII esterase with beta-lactamase activity from Paenibacillus sp., demonstrating its ability to hydrolyze nitrocefin, cefotaxime, and 7-aminocephalosporanic acid.

The study identifies several genes and mutations associated with antimicrobial resistance in Neisseria gonorrhoeae, including PenA, mtrR, 23S rRNA, rpsJ, PorB, PonA, GyrA, ParC, and bla. These genetic elements contribute to resistance against various antibiotics such as ceftriaxone, cefixime, azithromycin, tetracycline, ciprofloxacin, and penicillin.

The study shows that commensal bacteria producing functional beta-lactamase (BLA) can degrade ampicillin, reducing its efficacy against pathogens like Listeria monocytogenes and Clostridioides difficile.

The study identifies several genes upregulated in eravacycline-resistant Acinetobacter baumannii strains, including multidrug efflux RND transporter permease subunit, MSF transport, M1 family peptidase, Ade B pump, membrane protein, and class C extended-spectrum beta-lactamase ADC-26, indicating their potential role in eravacycline resistance.

The study identified beta-lactamase-producing Enterococcus faecalis and vancomycin-resistant Enterococcus faecium isolates, highlighting the presence of specific clones carrying resistance genes such as bla, vanA, and vanB.

The study identifies numerous antibiotic resistance genes (ARGs) in migratory birds, highlighting the presence of mcr-1, beta-lactamases, tetracycline resistance genes, and other resistance mechanisms. These findings suggest that migratory birds could serve as reservoirs and potential vectors for spreading ARGs into the environment.

The study identifies a beta-lactamase gene in Enterococcus faecalis that confers resistance to ampicillin, demonstrating that resistant populations can exhibit density-dependent effects on drug efficacy, leading to population survival or collapse based on initial conditions and drug influx rates.

The study identified extended-spectrum beta-lactamase (ESBL)-producing bacterial uropathogens, particularly Escherichia coli and Enterobacter cloacae, which exhibited resistance to third-generation cephalosporins and penicillins. Nitrofurantoin, gentamicin, and amikacin were found to be effective against these pathogens.

ETX1317 is a potent inhibitor of class A, C, and D serine beta-lactamases, restoring the antibacterial activity of β-lactams against multidrug-resistant Enterobacterales.

The study identified putative beta-lactamase genes in the metagenomes of Polok and Reshi hot springs, suggesting the presence of antibiotic resistance mechanisms in the microbial communities of these geothermal environments.

QPX7728 enhances the potency of meropenem against carbapenem-resistant Acinetobacter baumannii, particularly when combined with mutations in PBP3.

The study isolates and characterizes a novel Sphingobium yanoikuyae strain variant, CC4533, which exhibits resistance to certain antibiotics and can utilize various hydrocarbons and aromatic compounds as sole carbon sources.

The study identified that prophage-encoded antibiotic-resistance genes (ARGs) such as bla (ampicillin resistance), cat (chloramphenicol resistance), and neo (kanamycin resistance) confer resistance in Escherichia coli. The benefits of these ARGs and prophages vary depending on environmental conditions, with ARGs being more beneficial under antibiotic exposure and prophages being more beneficial when the lytic lifecycle is induced.

This review discusses various peptide antibiotics, including odilorhabdins, proline-rich antimicrobial peptides (PrAMPs), lipopeptides like daptomycin and polymyxins, and others, highlighting their mechanisms of action, in vivo efficacy, and potential for combating antimicrobial resistance.

Igni18, a metallo-beta-lactamase from Ignicoccus hospitalis, exhibits broad-spectrum beta-lactamase activity in the presence of Zn²⁺ and Ni²⁺, demonstrating its promiscuous enzymatic capabilities and metal-dependent substrate specificity.

The HMD-ARG framework accurately identifies antibiotic resistance genes (ARGs) and predicts their resistance mechanisms, antibiotic classes, and gene mobility without relying on sequence databases. It successfully identified novel ARGs in human gut microbiota and experimentally validated several predicted ARGs, demonstrating its effectiveness in detecting resistance genes.

The study identifies the role of beta-lactamase in mediating cooperative resistance in Enterococcus faecalis, demonstrating that resistant cells provide protection to sensitive cells over long distances under antibiotic stress.

The study identified a high prevalence of multidrug-resistant Klebsiella spp., with resistance genes against beta-lactam, fosfomycin, and quinolone detected in most isolates. Misidentification of species by MALDI-TOF MS was common, highlighting the need for genomic methods for accurate species identification.

VNRX-5236 is a broad-spectrum beta-lactamase inhibitor that effectively rescues ceftibuten activity against Enterobacterales expressing various beta-lactamases, including ESBLs, KPC, and OXA-48.

Klebsiella pneumoniae-derived outer membrane vesicles (OMVs) facilitate horizontal gene transfer, particularly of plasmids carrying the beta-lactamase gene, leading to ampicillin resistance in various bacterial species.

The study identified several AMR genes in Salmonella enterica isolates from dead chick embryos in China, including aac(6')-Iaa, qnrB4, bla, and sul1, which confer resistance to various antibiotics.

The study reveals that the Ω-loop pocket in beta-lactamase influences penicillin hydrolysis. Mutations affecting the Ω-loop pocket dynamics correlate with changes in benzylpenicillin activity, highlighting the functional relevance of this cryptic pocket.

The study identified the presence of beta-lactamase genes in E. coli isolates from dairy farm soils, indicating resistance to cefepoxy and cefoxitin. These findings highlight the potential for antimicrobial resistance dissemination in agricultural environments.

The study characterizes the Tn3.1 MIN cassette, which reduces the production of TEM-1 beta-lactamase, thereby decreasing antibiotic consumption and improving plasmid performance in bacterial cell factories.

Penicillin-resistant mutants of Streptococcus cremoris were isolated and found to produce beta-lactamase, leading to resistance against penicillin G and other beta-lactam antibiotics.

The study identified multidrug-resistant Escherichia coli strains from backyard poultry farms, with high resistance rates to ampicillin, gentamicin, and tetracycline. ESBL-producing E. coli were also detected, highlighting the public health concern of antimicrobial resistance in poultry.

Membrane vesicles (MVs) from methicillin-resistant Staphylococcus aureus (MRSA) can transfer beta-lactam resistance to antibiotic-susceptible Escherichia coli (RC85). MVs from RC85-T showed significantly higher beta-lactamase activity compared to MVs from the parent strain, contributing to increased resistance against beta-lactam antibiotics.

The study identifies cfiA and cepA as key carbapenem resistance genes in Bacteroides fragilis sensu stricto, and bla and cfx as important beta-lactam resistance genes in non-fragilis Bacteroides species. It also highlights the role of insertion sequences in activating cfiA-mediated carbapenem resistance.

The study identified several putative antimicrobial resistance genes within prophages of Lactobacillaceae, including vanZ, bla, and aph, which were analyzed for their potential role in resistance mechanisms.

The study identified a single beta-lactamase gene (bla) in S. aureus phages, which confers resistance to beta-lactam antibiotics through experimental validation.

The study identifies a high diversity of actinomycetoma pathogens, including three new Streptomyces species and one new Actinomadura species. It highlights the resistance profiles of these isolates, particularly noting the high resistance of Actinomadura madurae to various antibiotics, with rifampicin resistance genes detected in these strains.

The study identifies beta-lactam resistance genes in Enterobacter bugandensis and Bacillus cereus using a deep learning model and experimental validation through AST.

The study identified Oxa-376 and Oxa-530 variants of beta-lactamase in Acinetobacter baumannii, which exhibit increased resistance to carbapenems. Computational analyses and molecular docking suggested that point mutations in these variants enhance their enzymatic activity and resistance capabilities.

The study identifies various AMR genes and mutations in soil samples, highlighting the active resistome in agricultural and natural soils. Key findings include the detection of genes like gyrA, bcrA, and macB, which confer resistance to antibiotics such as ciprofloxacin and meropenem. The research emphasizes the importance of phenotypic resistance assessment in environmental AMR monitoring.

The study found that 94.1% of the 1939 Gram-negative isolates were susceptible to polymyxin B, and the sensitivity of the strains to polymyxin B was highly correlated with their sensitivity to colistin.

The study evaluated the probiotic properties of Pediococcus pentosaceus 1101, focusing on its resistance to acidic conditions and bile salts, as well as its antimicrobial activity against various bacteria. The strain exhibited high resistance to acidity (87% logarithmic survival rate at pH 2) and bile salts (99% logarithmic survival rate at 0.5% w/v), along with proteolytic and inhibitory activities. However, no specific AMR genes or mutations were identified in this paper.

The study characterizes various antibiotic resistance genes (ARGs) using a novel functional metagenomics approach called DEEPMINE, which enables the identification of ARGs in multiple bacterial hosts, revealing species-specific resistance profiles and expanding the understanding of antibiotic resistance mechanisms.

The study presents an optogenetic toolkit enabling light-inducible antibiotic resistance in Escherichia coli, utilizing genes such as bla, knt, cat, and tetA, which confer resistance to carbenicillin, kanamycin, chloramphenicol, and tetracycline, respectively.

The study identifies antimicrobial resistance genes (ARGs) in viruses inhabiting surfaces frequently touched by occupants and in viruses inhabiting occupants' skin, highlighting the presence of beta-lactamases, erythromycin resistance genes, vancomycin resistance genes, and tetracycline resistance genes in built environment viromes.

The study identifies the bla gene as a key factor in the development of plasmid-free cheater cells during laboratory growth, highlighting its role in beta-lactam resistance and the subsequent emergence of cells that exploit the detoxification of antibiotics.

The essential oil of Piper tuberculatum fruits inhibits beta-lactamase and efflux pumps (NorA, Tet(K), and MepA) in multidrug-resistant Staphylococcus aureus strains, enhancing antibiotic activity.

The study identified several antibiotic resistance genes in Staphylococcus equorum strains from cheese, including blaR1-blaZI, bla, mph(C), msr(A), norA, fosB/fosD, and cat, which confer resistance to various antibiotics such as beta-lactams, macrolides, fluoroquinolones, fosfomycin, and chloramphenicol.

The study explores the use of membrane-active metallopolymers as adjuvants to enhance the efficacy of existing antibiotics against multidrug-resistant (MDR) Gram-negative bacteria, including biofilm disruption and overcoming resistance mechanisms.

The study identifies the carbapenemase gene blaIMP-11 as responsible for meropenem resistance in Bacillus sp. FW 1, and shows that this resistance is not transferable.

The study characterizes TEM-1 beta-lactamase variants with specific mutations (G238S, E104K, M182T) that enhance cefotaxime hydrolysis, demonstrating their role in cross-protection against β-lactam antibiotics.

The study identified multiple antibiotic resistance genes in Pseudomonas aeruginosa strain S3, including beta-lactamases, fosfomycin resistance gene fosA, aminoglycoside resistance gene aph, chloramphenicol resistance gene catB, and multiple efflux pump genes such as mexAB-oprM, mexCD-oprJ, mexEF-oprN, mexXY, mexVW-oprM, mexJK-oprM, mexHI-opmD, mexPQ-opmE, acrAB-tolC, oqxAB, and mcr. Additionally, hemolysin genes like plcH, choE, and papA were also identified.

The study identified seven novel Ralstonia species and characterized their antimicrobial resistance patterns, revealing widespread beta-lactam resistance.

The study found that 64.4% of E. coli isolates produced β-lactamases, with penicillinase production being the most common resistance mechanism. Extended-spectrum β-lactamase (ESBL) production was observed in 6.1% of isolates.

Phage predation increases the spread of plasmid-encoded antibiotic resistance by slowing the spatial demixing of different microbial populations during surface-associated growth.

The study demonstrates that the private benefit of beta-lactamase production influences the selection dynamics of combination antibiotic treatment, with higher private benefits leading to increased selection for resistance.

The study identified 448 drug resistance genes in the goat-derived K. oxytoca strain KOHN1, including genes conferring resistance to beta-lactams, tetracyclines, fluoroquinolones, and fosfomycins. It also identified 146 virulence genes, including vgrG, hcp, clpV, and fimA.

The study identifies a beta-lactamase gene (bla) in Enterococcus faecalis that confers resistance to ampicillin through enzymatic degradation, demonstrating cooperative resistance mechanisms in spatially structured bacterial communities.

The study identifies that the pBMN-I-GFP plasmid had an inverted beta-lactamase (bla) gene and promoter, leading to lack of ampicillin and carbenicillin resistance. Correcting the orientation restored resistance.

The study identified a variety of antimicrobial and metal resistance genes in bacteria isolated from mine water in Austria, highlighting the prevalence of multidrug efflux pumps and beta-lactamase genes. It also noted the presence of specific metal resistance genes such as ruvB, copA, recGM, and mgtA, as well as co-resistance genes like arsBM, acrD, and the mer operon.

The study identified carbapenem-resistant Acinetobacter baumannii (CRAB) as the causative agent of an outbreak in an ICU during the COVID-19 epidemic. Whole genome sequencing revealed the presence of the intrinsic carbapenem resistance gene oxa-51 and bla genes, which conferred resistance to carbapenems.

The study introduces dynamically chiral phosphonic acid-based inhibitors that effectively inhibit metallo-beta-lactamase enzymes VIM-2, GIM-1, and NDM-1, providing a novel approach to combat β-lactam resistance.

The study identified extended-spectrum beta-lactamase (ESBL) and carbapenemase-producing gram-negative bacteria on healthcare workers' mobile phones, highlighting the need for improved infection control measures.

The study characterizes mutations in the bla gene of E. coli that confer resistance to cefotaxime, highlighting the fitness costs and trade-offs associated with these resistance mutations.

The study identifies seven beta-lactamase genes (bla ampC, bla TEM-1, bla CTX-M-15, bla CMY-2, bla NDM-5, bla KPC-2, and bla OXA-181) in E. coli that contribute to cooperative resistance, with varying levels of efficacy in rescuing susceptible cells and facilitating cross-protection against β-lactam antibiotics.

The study evaluated the effectiveness of cefepime-taniborbactam against cefepime-resistant Enterobacterales and Pseudomonas aeruginosa, identifying the presence of various beta-lactamase genes such as blaNDM-1, blaVIM-1, blaVIM-4, blaKPC-2, and blaOXA-48, which contribute to resistance against beta-lactam antibiotics.

The study identified several antimicrobial resistance (AMR) genes in a dairy wastewater sample, including beta-lactamases, aminoglycoside acetyltransferases, tetracycline resistance proteins, quinolone resistance proteins, and macrolide ribosome methyltransferases. These genes were found in various bacterial species such as Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, and Pseudomonas aeruginosa.

APC24-7, a compound combining a boronic acid and a Zn2+-chelator, effectively restores meropenem susceptibility in metallo-beta-lactamase (MBL)-producing bacteria, including those resistant to taniborbactam.

Klebsiella pneumoniae and Bacillus paranthracis degrade cefotaxime (CTX) through beta-lactamase activity, enabling Pseudomonas aeruginosa to expand spatially despite CTX treatment.

The paper discusses the emergence and characteristics of antibiotic-resistant Staphylococcus aureus, focusing on resistance mechanisms such as beta-lactamase production for penicillin resistance.

The study describes the construction of pACYC-derived plasmid vectors containing the bla gene encoding ampicillin resistance.

The study identified and characterized the bla gene encoding the BRO-1 beta-lactamase in Moraxella (Branhamella) catarrhalis, demonstrating that it is solely responsible for beta-lactam resistance.

The study explores the molecular evolution of bacterial beta-lactam resistance, focusing on the structural similarities and differences between beta-lactamases and DD-peptidases, suggesting that beta-lactamases evolved from ancestral proteins involved in cell wall synthesis.

A penicillin-sensitive, non-beta-lactamase producing strain of Neisseria gonorrhoeae acquired beta-lactamase activity after treatment with ethidium bromide.