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bla TEM-1

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to bla TEM-1

Browse AMR rules for bla TEM-1

Overview

Drug Classes: Co-amoxiclav
Organisms: Escherichia coli
Papers: 1
Mutations: 2

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
-	C32T	increases expression	Escherichia coli	Co-amoxiclav	Reslit	Candidate
-	G175A	increases expression	Escherichia coli	Co-amoxiclav	Reslit	Candidate

Papers1

1

Escherichia coli phylogeny drives co-amoxiclav resistance through variable expression of TEM-1 beta-lactamase.

PMID 41028731 · 2025

Promoter mutations C32T and G175A increase bla TEM-1 expression and co-amoxiclav resistance.

Mutation Information

bla TEM-1: c.C32T bla TEM-1: c.G175A

Nucleotide Change: C32T, G175A
Organisms: Escherichia coli
Confers Resistance To: Co-amoxiclav
Effect on Function: increases expression
Source Database: Reslit