blaA
class A beta-lactamase
NCBI Pathogen Isolates
Bacterial genomes carrying this gene
NCBI Reference Gene Catalog
Known alleles and reference sequences
UniProt
Protein entries specific to blaA
AMR Rules
Browse AMR rules for blaA
Validation StatusCandidate
Overview
- Mechanism
- mutated beta-lactamase enzyme conferring resistance to ceftazidime and clavulanic acid
- Validation Method
- cloning and enzyme kinetics analysis
- Drug Classes
- ceftazidime
- Organisms
- Burkholderia pseudomallei, Escherichia coli
- Geographic Location
- Thailand|Canada
- Papers
- 1
- Databases
- Reslit
- Mutations
- 1
Mutations
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| P167S | - | - | Burkholderia pseudomallei | ceftazidime | Reslit | Candidate |
Papers1
1
Burkholderia pseudomallei class a beta-lactamase mutations that confer selective resistance against ceftazidime or clavulanic acid inhibition.
The study identifies specific mutations in the class A beta-lactamase gene (blaA) of Burkholderia pseudomallei that confer resistance to ceftazidime and clavulanic acid. These mutations occur in conserved regions of the enzyme, affecting its ability to be inhibited by these antibiotics.
Gene Information
- Gene Name
- blaA
- Allele
- BlaA
- Encodes
- class A beta-lactamase
- Source Database
- Reslit
- Mechanism
- mutated beta-lactamase enzyme conferring resistance to ceftazidime and clavulanic acid
- Confers Resistance To
- ceftazidime
- Organisms Tested In
- • Burkholderia pseudomallei• Escherichia coli
- Geographic Location
- Thailand|Canada
- Validation Method
- cloning and enzyme kinetics analysis
- Sequence Accession
- AY032868|AY032869|AY032870|AY032871|AY032872|AY032873|AY032874
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