The study identified plasmid-encoded beta-lactamases TEM-4, SHV-2a, and ACC-1a in Salmonella enterica serotype Mbandaka isolates resistant to broad-spectrum cephalosporins.

The study developed a multiplex asymmetric PCR-based microarray for detecting drug resistance genes containing single mutations in Enterobacteriaceae, focusing on beta-lactamase genes such as bla SHV, bla TEM, bla CTX-M-3, bla CTX-M-9, bla DHA-1, bla CMY-2, bla MOX-1, bla ACC-1, bla FOX-5, and bla MIR-1. It also identified six point mutations in the bla SHV gene.

The study identified several acquired AmpC beta-lactamases, including CMY-2, CMY-25, CMY-27, CMY-40, DHA-1, and ACC-1, in Enterobacteriaceae strains from a Spanish hospital between 1999 and 2007. These enzymes conferred resistance to various beta-lactam antibiotics and other drugs.

The study identifies the presence of blaACC-1 and blaTEM-1 beta-lactamase genes in a multidrug-resistant Salmonella enterica serovar Typhi isolate from India, which exhibited resistance to several beta-lactam antibiotics.

The study characterizes the carbapenem-hydrolyzing activities of five plasmid-borne AmpC beta-lactamases (CMY-2, ACT-1, DHA-1, FOX-1, and ACC-1) and shows that CMY-2, ACT-1, and DHA-1 confer resistance to imipenem, while FOX-1 and ACC-1 do not.

The study presents the complete nucleotide sequence of the IncB plasmid pR3521 from Escherichia coli, which contains three beta-lactamase genes: blaACC-4, blaSCO-1, and blaTEM-1. These genes confer resistance to various beta-lactam antibiotics.

The study identified various plasmid-borne antimicrobial resistance genes in multi-drug-resistant Enterobacteriaceae isolates from a newly opened hospital in Iraq, including aminoglycoside, beta-lactam, sulfamethoxazole/trime-thoprim, tetracycline, and chloramphenicol resistance genes.

The study detected Amp C genes in 29.87% of the study isolates, with the majority co-producing ESBL. The most common Amp C was the CIT family.

The study identified 13 pAmpC-producing Enterobacteriaceae isolates, including 9 CMY-2, 3 DHA-1, and 1 ACC-1 type in E. coli isolates. The prevalence of pAmpC was found to be 2.6% among group I Enterobacteriaceae.

The study characterized β-lactamase genes in baseline pathogens from patients enrolled in phase 2 trials for ceftazidime-avibactam, identifying CTX-M-14, CTX-M-15, OXA-1, TEM-1, OXA-1/30, SHV-12, ACC-4, CMY-42, NDM-1, VIM-2, PER-1, and OXA-23 as key resistance determinants against ceftazidime.

The study identified various beta-lactamase genes, including blaSHV-1, blaTEM-1, blaCTX-M-55, blaCTX-M-65, blaDHA-1, blaCMY-2, blaACC-1, and blaCIT, which confer resistance to multiple beta-lactam antibiotics in Enterobacteriaceae isolated from retail food and water samples in Guangzhou, China.

The study developed and evaluated the REBA-EAC assay for the rapid detection of clinically relevant antibiotic resistance genes in blood cultures positive for Gram-negative bacteria. The assay successfully identified various beta-lactamase genes, including ESBLs (CTX-M, TEM, SHV), AmpC beta-lactamases (DHA, CMY-2-like, ACT), and carbapenemases (IMP, VIM, NDM, KPC, OXA-48-like, SPM).

The study identified several antibiotic resistance genes, including MOX, ACC, bla CTX-M, and Int1, in pathogenic bacteria isolated from freshwater shrimp and Kung Ten salad, indicating potential risks for foodborne diseases.

Two resistance mechanisms to BASA were identified in S. aureus: deletion of pc and a missense mutation in bpl (D200E). The low spontaneous resistance rate suggests BPL is a promising antibacterial target.

The study identifies blaVIM-1 and blaVIM-2 as the primary metallo-beta-lactamase genes in clinical and environmental Enterobacteriaceae isolates in Ontario, Canada. Additionally, blaACC-1, blaCTX-M-15, and blaOXA-1 were found to contribute to antimicrobial resistance.

The study identified multiple ESBL genes, including bla CTX-M-14, bla CTX-M-15, bla CTX-M-55, bla CMY-2, bla ACC-1, and bla TEM-1, along with PMQR genes such as qnrA, qnrB, qnrS, and aac(6′)-Ib-cr, contributing to resistance against cephalosporins and fluoroquinolones in Salmonella Choleraesuis isolates from Thailand.

The study evaluated two phenotypic methods for detecting plasmid-mediated AmpC beta-lactamases in Enterobacteriaceae isolates and identified several plasmid-mediated AmpC genes including ACC, FOX, MOX, DHA, CIT, and EBC using multiplex PCR.

The study identifies plasmid-mediated AmpC β-lactamase genes (ACC, FOX, MOX, DHA, CIT, EBC) in clinical isolates of Enterobacteriaceae in Bahrain, highlighting their association with multidrug resistance.

The study identified blaSHV, blaTEM, blaCTX-M, blaFOX, blaDHA, and blaACC genes as the primary contributors to extended-spectrum beta-lactamase and AmpC beta-lactamase production in Enterobacteriaceae isolated from humans, cattle, and poultry in Egypt.

The study identifies several β-lactamase genes, including SHV-12, CTX-M group variants, TEM, OXA, and PMAβ, as well as the mcr-1 gene responsible for polymyxin resistance in E. coli isolates from broilers raised in intensive and extensive systems. The prevalence of reduced susceptibility to antibiotics is higher in isolates from the intensive system.

The study established a multiplex PCR method to detect six families of AmpC beta-lactamase genes (ACC, EBC, CIT, DHA, MOX, and FOX) in gram-negative bacteria, demonstrating high sensitivity and specificity.

The study identified various antibiotic resistance genes and virulence genes in Vibrio cholerae and Vibrio mimicus isolates from seafood samples in South Africa, highlighting the presence of resistance to multiple antibiotics including polymyxin B, ampicillin, and fluoroquinolones.

The study identified numerous antibiotic resistance genes (ARGs) and metal resistance genes (MRGs) in the metagenomes of Lake Afdera and the Assale salt plain in the Danakil Depression. Key ARGs included beta-lactamases (ACC-1, OXA-58, OXA-363, OXA-212, NDM-17, OXA-134, ACT-29, LRA-19), efflux pumps (emrB, abeM, abeS, mgrA, adeJ, MexC, adeL, adeH), sulfonamide resistance genes (sul1, sul2), tetracycline resistance genes (tet39, tetX, tetK), and others. MRGs included copper resistance genes (copC, copD), cadmium resistance gene (cadD), mercury resistance gene (merA), chromate resistance genes (chrB, chrA), nickel-cobalt-cadmium resistance genes (nccA, nccB), cobalt-zinc-cadmium resistance gene (czcD), arsenic resistance gene (arsO), lead resistance gene (pbrA), and mercury resistance genes (merB, merR, MIR).

The paper discusses the prevalence of antimicrobial resistance in Aeromonas species, highlighting the presence of various beta-lactamase genes such as blaTEM-24, blaIMP-19, blaVIM-4, blaKPC-2, blaNDM-1, blaVIM-2, blaOXA-48, blaIMP-13, blaGES-5, blaTEM-1, blaSHV-12, blaVEB-9, blaMOX, blaFOX, blaACC, and others. It also identifies genes like cphA, vat, mcr-3.41, mcr-7.1, sul, dfr, tetA, rsmA, and adeF associated with resistance to sulfonamides, trimethoprim, tetracycline, polymyxin, and other antibiotics. The study emphasizes the role of horizontal gene transfer and mobile genetic elements in the dissemination of these resistance genes.

The study evaluates the inhibitory activities of various beta-lactamase inhibitors against a wide range of AmpC beta-lactamases, identifying the effectiveness of certain inhibitors like durlobactam and zidebactam in reducing the MIC values of β-lactam antibiotics against AmpC-producing strains.

The study identified the presence of bla CTX-M, bla SHV, qnr B, and bla ACC-1 genes among P. aeruginosa isolates, indicating the presence of multiple antibiotic resistance mechanisms.

The study presents a massive culture-based approach for the screening of AmpC, ESBL, and carbapenemase producers from rectal swabs, demonstrating improved specificity for detecting ESBL producers compared to conventional methods. It identifies various beta-lactamase genes, including bla CTX-M-1/2-like, bla CTX-M-8-like, bla CTX-M-9-like, bla SHV-like, bla TEM-like, bla GES-like, bla MOX, bla CIT, bla DHA, bla ACC, bla EBC, bla FOX, bla CMY-2, and bla NDM.

The study identifies multiple beta-lactamase resistance genes in ESBL-PE strains, including blaCTX-M-14, blaCTX-M-1, blaCTX-M-3, blaCTX-M-15, blaCTX-M-65, blaSHV, blaTEM, blaEC, blaACC, blaCMY, blaACT, blaDHA, and efflux pump genes such as acrF, emrD, mdtM, silA, kdeA, oqxA, oqxB, arsB, oqxA10, oqxB5, oqxB19, arsA, and hugA, which contribute to multidrug resistance in these isolates.

CAI0019 is a carbonic anhydrase inhibitor that shows efficacy against Enterococcus faecium in a mouse model, with minimal impact on the gut microbiome. The α-carbonic anhydrase was identified as the primary target of CAI0019.

The study identified various ESBL and AmpC genes, including bla CTX-M-1, bla CTX-M-9, bla TEM, bla SHV, bla OXA, bla CIT, bla MOX, bla DHA, bla ACC, bla EBC, and bla FOX, in ESBL-producing E. coli isolates from broiler neck skin. These genes were associated with resistance to beta-lactam antibiotics such as cefotaxime, ceftazidime, and cefoxitin.