Browse AMR Genes

Explore antimicrobial resistance genes from the literature

blaACI

extended-spectrum class A beta-lactamase ACI-1

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to blaACI

Browse AMR rules for blaACI

Validation StatusConfirmed2+ DBs

Overview

Mechanism: Enzymatic inactivation
Validation Method: cloning in E. coli + MIC testing
Drug Classes: TICARCILLIN, AMOXICILLIN, AMPICILLIN, CEFTAZIDIME, CEFOTAXIME, CEPHALOSPORIN, Penicillin, Amoxicillin, Ticarcillin, Cefotaxime, Ceftazidime, Cephalosporin, Beta-lactams, Cefoxitin, Ceftriaxone, Ampicillin
Organisms: Acidaminococcus fermentans, Escherichia coli, Salmonella, Enterobacteriaceae
Geographic Location: Europe, United States
Alleles: 3
Papers: 4
Databases: Card DatabaseReference Gene CatalogResFinder DatabaseReslit

Allele Variants3

Allele	Database	Papers	Drug Classes	Organisms	Countries	Years	Sequence Accession	Protein Accession
blaACI-1	Card DatabaseReference Gene CatalogResFinder DatabaseReslit	5	TICARCILLIN, AMOXICILLIN +9	Acidaminococcus fermentans +1

Papers4

1

ACI-1 from Acidaminococcus fermentans: characterization of the first beta-lactamase in Anaerobic cocci.

PMID 11036038 · 2000

Gene Information

Gene Name: blaACI
Allele: blaACI-1
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: TICARCILLINAMOXICILLINAMPICILLINCEFTAZIDIMECEFOTAXIME
Organisms Tested In: • Acidaminococcus fermentans
Sequence Accession: AJ007350

2

ACI-1 from Acidaminococcus fermentans: characterization of the first beta-lactamase in Anaerobic cocci.

PMID 11036038 · 2000

Gene Information

Gene Name: blaACI
Allele: blaACI-1
Encodes: extended-spectrum class A beta-lactamase ACI-1
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: TICARCILLINCEPHALOSPORINAMOXICILLINAMPICILLINCEFTAZIDIMECEFOTAXIME
Organisms Tested In: • Acidaminococcus fermentans
Sequence Accession: AJ007350.1
Protein Accession: CAB51471.1
Notes: ARO:3004359

3

ACI-1 from Acidaminococcus fermentans: characterization of the first beta-lactamase in Anaerobic cocci.

PMID 11036038 · 2000

Gene Information

Gene Name: blaACI
Allele: blaACI-1
Encodes: extended-spectrum class A beta-lactamase ACI-1, ACI beta-lactamase
Source Database: Card Database
Mechanism: Enzymatic inactivation, antibiotic inactivation
Confers Resistance To: TICARCILLINCEPHALOSPORINAMOXICILLINAMPICILLINCEFTAZIDIMECEFOTAXIME
Organisms Tested In: • Acidaminococcus fermentans
Sequence Accession: AJ007350.1
Protein Accession: CAB51471.1
Notes: ARO:3004359

4

ACI-1 from Acidaminococcus fermentans: characterization of the first beta-lactamase in Anaerobic cocci.

PMID 11036038 · 2000

The study characterizes ACI-1, a novel class A beta-lactamase from Acidaminococcus fermentans, which confers resistance to penicillins and expanded-spectrum cephalosporins.

Gene Information

Gene Name: blaACI
Allele: blaACI-1
Encodes: beta-lactamase
Source Database: Reslit
Mechanism: beta-lactamase
Confers Resistance To: PenicillinAmoxicillinTicarcillinCefotaximeCeftazidime
Organisms Tested In: • Acidaminococcus fermentans
• Escherichia coli
Validation Method: cloning in E. coli + MIC testing
Sequence Accession: AJ007350

5

ACI-1 from Acidaminococcus fermentans: characterization of the first beta-lactamase in Anaerobic cocci.

PMID 11036038 · 2000

Gene Information

Gene Name: blaACI
Allele: blaACI-1
Encodes: extended-spectrum class A beta-lactamase ACI-1
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: TICARCILLINCEPHALOSPORINAMOXICILLINAMPICILLINCEFTAZIDIMECEFOTAXIME
Organisms Tested In: • Acidaminococcus fermentans
Sequence Accession: AJ007350.1
Protein Accession: CAB51471.1
Notes: ARO:3004359

6

Effects of Ceftiofur and Chlortetracycline on the Resistomes of Feedlot Cattle.

PMID 29728379 · 2018

The study found that tetracycline resistance genes, particularly tet(Q) and tet(40), were significantly enriched in cattle fed chlortetracycline. β-lactam resistance genes such as bla_CFX-A6 and bla_ACI-1 were also identified, but no significant changes were observed in their relative abundances. Aminoglycoside resistance genes showed an increase despite no aminoglycoside administration.

Gene Information

Gene Name: blaACI
Allele: bla_ACI-1
Encodes: beta-lactamase
Source Database: Reslit
Confers Resistance To: Cephalosporin
Organisms Tested In: • Escherichia coli
• Salmonella
Geographic Location: United States
Validation Method: metagenomic sequencing

7

Longitudinal study of the short- and long-term effects of hospitalisation and oral trimethoprim-sulfadiazine administration on the equine faecal microbiome and resistome.

PMID 36850017 · 2023

Oral trimethoprim-sulfadiazine (TMS) administration leads to a significant and long-lasting increase in the relative abundance of resistance genes sul2, tetQ, ant6-1a, aph(3"-lb, and lnuC in the equine faecal microbiome.

Gene Information

Gene Name: blaACI
Allele: blaACI
Encodes: beta-lactam resistance
Source Database: Reslit
Confers Resistance To: Beta-lactams
Geographic Location: Europe
Validation Method: metagenomic assembly

8

Abundance and prevalence of ESBL coding genes in patients undergoing first line eradication therapy for Helicobacter pylori.

PMID 37561723 · 2023

The study identified several ESBL coding genes, including bla OXY, bla ADC, bla IMP, bla OXA, bla L1, bla LRA, bla EC, bla ACI, and bla FAR, which were found to be prevalent in patients undergoing H. pylori eradication therapy. The abundance of these genes varied between pre- and post-eradication states.

Gene Information

Gene Name: blaACI
Allele: blaACI
Encodes: beta-lactamase
Source Database: Reslit
Confers Resistance To: CefoxitinCefotaximeCeftriaxoneAmpicillinPenicillin
Organisms Tested In: • Enterobacteriaceae
Geographic Location: Europe
Validation Method: metagenomic sequencing