Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
subclass B3 metallo-beta-lactamase AIM-1, AIM beta-lactamase
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| blaAIM-1 | Card DatabaseReference Gene CatalogReslit | 11 | CARBAPENEM, Penicillin +10 | Pseudomonas aeruginosa +7 | Australia, India, Australia|Iraq|Asia|North America|Europe, Brazil, Asia/South Pacific|Europe|Latin America|Middle East/Africa|North America |
| 2012, 2017, 2019, 2020, 2021, 2022, 2024 |
| AM998375.1 |
| CAQ53840.1 |
| blaAIM | Reslit | 2 | Meropenem, Imipenem | Acinetobacter spp. +1 | Europe|Greece, China | 2024, 2025 | - | - |
| blaAIM-2 | Card DatabaseReference Gene Catalog | 2 | CARBAPENEM | uncultured bacterium | - | - | OK067203.1 | UBK05373.1 |
Genetic and biochemical characterization of an acquired subgroup B3 metallo-β-lactamase gene, blaAIM-1, and its unique genetic context in Pseudomonas aeruginosa from Australia.
Genetic and biochemical characterization of an acquired subgroup B3 metallo-β-lactamase gene, blaAIM-1, and its unique genetic context in Pseudomonas aeruginosa from Australia.
Genetic and biochemical characterization of an acquired subgroup B3 metallo-beta-lactamase gene, blaAIM-1, and its unique genetic context in Pseudomonas aeruginosa from Australia.
The study characterizes blaAIM-1, a novel subgroup B3 metallo-beta-lactamase gene found in Pseudomonas aeruginosa isolates from Australia, which confers resistance to various β-lactam antibiotics except aztreonam, cefepime, imipenem, and meropenem.
Insights into an evolutionary strategy leading to antibiotic resistance.
The study identifies mutations in the metallo-beta-lactamase AIM-1 that enhance resistance to beta-lactam antibiotics, particularly cefoxitin and imipenem, through alterations in substrate recognition and catalytic efficiency.
Suppression of β-Lactam Resistance by Aspergillomarasmine A Is Influenced by both the Metallo-β-Lactamase Target and the Antibiotic Partner.
The study characterizes the effectiveness of Aspergillomarasmine A (AMA) in suppressing β-lactam resistance mediated by various metallo-β-lactamases (MBLs), including NDM-1, VIM-2, CphA2, and AIM-1, demonstrating that AMA can restore meropenem activity against MBL-producing bacteria.
Metagenome of a polluted river reveals a reservoir of metabolic and antibiotic resistance genes.
The study identified a diverse range of antibiotic resistance genes in the Yamuna River, including metallo-beta-lactamases such as bla NDM-1, bla NDM-8, and others, indicating a significant reservoir of resistance in the river's microbial community.
Worldwide distribution and environmental origin of the Adelaide imipenemase (AIM-1), a potent carbapenemase in Pseudomonas aeruginosa.
The study identifies the blaAIM-1 gene as a major determinant for high-level carbapenem resistance in Pseudomonas aeruginosa. The gene was found to be widely distributed in local wastewater samples and globally, and its origin is linked to the non-pathogenic environmental organism Pseudoxanthomonas mexicana.
Structural Insights for Core Scaffold and Substrate Specificity of B1, B2, and B3 Metallo-β-Lactamases.
The study provides structural insights into the core scaffold and substrate specificity of B1, B2, and B3 metallo-beta-lactamases, highlighting their roles in hydrolyzing various beta-lactam antibiotics.
Exploring the Bacteriome and Resistome of Humans and Food-Producing Animals in Brazil.
The study identified various antimicrobial resistance genes (ARGs) in humans and food-producing animals in Brazil, including novel carbapenemase-encoding genes such as blaAIM-1, blaCAM-1, blaGIM-2, and blaHMB-1, which were not previously reported in Latin America. Other significant ARGs included aac(6')-Ib-cr, ermF, ermB, ermG, tetO, tetQ, tetW, qnrB10, qnrB19, qnrD1, and crpP.
Relative inhibitory activities of the broad-spectrum beta-lactamase inhibitor taniborbactam against metallo-beta-lactamases.
The study evaluates the inhibitory activity of taniborbactam against various metallo-beta-lactamases (MBLs), demonstrating that it effectively inhibits most NDM- and VIM-like enzymes but not SIM-1. Specific mutations in VIM-1 and NDM-1 were found to confer resistance to taniborbactam.
Cefepime-taniborbactam activity against antimicrobial-resistant clinical isolates of Enterobacterales and Pseudomonas aeruginosa: GEARS global surveillance programme 2018-22.
Cefepime-taniborbactam showed potent in vitro activity against Enterobacterales and P. aeruginosa, particularly effective against isolates with carbapenemase genes such as blaIMP, blaNDM, and blaVIM, as well as those with mutations in ftsI, ompK35, and ompK36.
Prevalence, Characterization, and Epidemiological Relationships between ESBL and Carbapenemase-Producing Escherichia coli, Klebsiella pneumoniae, and Acinetobacter spp. Isolated from Humans and the Kitchen Environment of Two Greek Hospitals.
The study identified various beta-lactamase genes, including bla SHV, bla CTX-M, bla TEM, bla KPC, bla NDM, bla OXA-48, bla OXA-23, and bla OXA-51, in ESBL and carbapenemase-producing E. coli, K. pneumoniae, and Acinetobacter spp. isolates from hospital kitchens and staff.
Antimicrobial multidrug resistance of Escherichia coli from broiler farms in Zhanjiang, China.
The study identified multiple AMR genes in E. coli isolates from broiler farms in Zhanjiang, China, including bla TEM, bla AIM, pexA, aadA1, ant(3")-I, sul2, and sul3, which were associated with multidrug resistance to various antibiotics.
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