Browse AMR Genes

Explore antimicrobial resistance genes from the literature

blaAMZ

beta-lactamase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to blaAMZ

Browse AMR rules for blaAMZ

Validation StatusConfirmed2+ DBs

Overview

Mechanism: antibiotic inactivation
Validation Method: cloning in E. coli + MIC testing
Drug Classes: Amoxicillin, Penicillin, Ampicillin, Cephalothin, Cefoxitin, CEPHALOSPORIN, Meropenem, Imipenem
Organisms: Achromobacter mucicolens Y3, Escherichia coli DH5α, Escherichia coli BL21 (DE3), Achromobacter mucicolens
Geographic Location: United States, Wenzhou, Zhejiang Province, China
Alleles: 2
Papers: 2
Databases: Card DatabaseReference Gene CatalogReslit

Allele Variants2

Allele	Database	Papers	Drug Classes	Organisms	Countries	Years	Sequence Accession	Protein Accession
bla(AMZ-1)	Reslit	1	Amoxicillin, Penicillin +3	Achromobacter mucicolens Y3 +2	Wenzhou, Zhejiang Province, China	2023	CP123364\|OQ948417	-
blaAMZ-1

Papers2

1

Identification and characterization of a novel beta-lactamase gene, bla(AMZ-1), from Achromobacter mucicolens.

PMID 37808287 · 2023

A novel beta-lactamase gene, bla(AMZ-1), was identified and characterized from Achromobacter mucicolens Y3. This gene confers resistance to several β-lactam antibiotics, including amoxicillin, penicillin G, ampicillin, cephalothin, and cefoxitin.

Gene Information

Gene Name: blaAMZ
Allele: bla(AMZ-1)
Encodes: beta-lactamase
Source Database: Reslit
Confers Resistance To: AmoxicillinPenicillinAmpicillinCephalothinCefoxitin
Organisms Tested In: • Achromobacter mucicolens Y3
• Escherichia coli DH5α
• Escherichia coli BL21 (DE3)
Geographic Location: Wenzhou, Zhejiang Province, China
Validation Method: cloning in E. coli + MIC testing
Sequence Accession: CP123364|OQ948417

2

Identification and characterization of a novel β-lactamase gene, bla(AMZ-1), from Achromobacter mucicolens.

PMID 37808287 · 2023

Gene Information

Gene Name: blaAMZ
Allele: blaAMZ-1
Encodes: class C beta-lactamase AMZ-1
Source Database: Reference Gene Catalog
Mechanism: antibiotic inactivation
Confers Resistance To: CEPHALOSPORIN
Organisms Tested In: • Achromobacter mucicolens
Sequence Accession: CP123364.1
Protein Accession: WGJ88903.1
Notes: ARO:3007694

3

Identification and characterization of a novel β-lactamase gene, bla(AMZ-1), from Achromobacter mucicolens.

PMID 37808287 · 2023

Gene Information

Gene Name: blaAMZ
Allele: blaAMZ-1
Encodes: class C beta-lactamase AMZ-1
Source Database: Card Database
Mechanism: antibiotic inactivation
Confers Resistance To: CEPHALOSPORIN
Organisms Tested In: • Achromobacter mucicolens
Sequence Accession: CP123364.1
Protein Accession: WGJ88903.1
Notes: ARO:3007694

4

Defining antimicrobial susceptibility testing methods and breakpoints among Achromobacter species.

PMID 40304527 · 2025

The study identifies several beta-lactamase genes, including bla OXA-114, bla AXC, bla VIM-4, and bla AMZ-1, which confer resistance to carbapenems in Achromobacter species. These findings are crucial for establishing antimicrobial susceptibility testing breakpoints.

Gene Information

Gene Name: blaAMZ
Allele: blaAMZ-1
Encodes: beta-lactamase
Source Database: Reslit
Confers Resistance To: MeropenemImipenem
Organisms Tested In: • Achromobacter mucicolens
Geographic Location: United States
Validation Method: whole-genome sequencing

5

Gene Information

Gene Name: blaAMZ
Allele: blaAMZ-1
Encodes: AMZ beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Organisms Tested In: • Achromobacter mucicolens
Sequence Accession: OQ948417.1
Protein Accession: WHL54874.1
Notes: ARO:3007694