blaAST

beta-lactamase

Validation StatusConfirmed2+ DBs

Overview

Mechanism: hydrolysis of beta-lactam antibiotics
Validation Method: expression in E. coli JM109 and MIC testing
Drug Classes: Penicillin, Cephalosporins, BETA-LACTAM, TICARCILLIN, AMOXICILLIN, AMPICILLIN+CLAVULANIC ACID, AMPICILLIN, AMOXICILLIN+CLAVULANIC ACID, PIPERACILLIN+TAZOBACTAM, PIPERACILLIN, Amoxicillin/clavulanic acid
Organisms: Nocardia asteroides sensu stricto, Escherichia coli, Nocardia asteroides, Nocardia cyriacigeorgica
Geographic Location: Venezuela
Papers: 2
Databases: Card DatabaseReference Gene CatalogResFinder DatabaseReslit

Papers2

Molecular and biochemical analysis of AST-1, a class A beta-lactamase from Nocardia asteroides sensu stricto.

PMID 11181374 · 2001

The study characterizes AST-1, a class A beta-lactamase from Nocardia asteroides sensu stricto, which confers resistance to penicillins and narrow-spectrum cephalosporins.

Gene Information

Gene Name: blaAST
Allele: blaAST-1
Encodes: beta-lactamase
Source Database: Reslit
Mechanism: hydrolysis of beta-lactam antibiotics
Confers Resistance To: PenicillinCephalosporins
Organisms Tested In: • Nocardia asteroides sensu stricto
• Escherichia coli
Validation Method: expression in E. coli JM109 and MIC testing
Sequence Accession: AF279904

Molecular and biochemical analysis of AST-1, a class A beta-lactamase from Nocardia asteroides sensu stricto.

PMID 11181374 · 2001

Gene Information

Gene Name: blaAST
Allele: blaAST-1
Encodes: broad-spectrum class A beta-lactamase AST-1
Source Database: Reference Gene Catalog
Mechanism: antibiotic inactivation
Confers Resistance To: BETA-LACTAM
Organisms Tested In: • Nocardia asteroides
Sequence Accession: AF279904.1
Protein Accession: AAG44836.1
Notes: ARO:3004740

Molecular and biochemical analysis of AST-1, a class A beta-lactamase from Nocardia asteroides sensu stricto.

PMID 11181374 · 2001

Gene Information

Gene Name: blaAST
Allele: blaAST-1
Encodes: broad-spectrum class A beta-lactamase AST-1, AST Beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Confers Resistance To: BETA-LACTAM
Organisms Tested In: • Nocardia asteroides
Sequence Accession: AF279904.1
Protein Accession: AAG44836.1
Notes: ARO:3004740

Molecular and biochemical analysis of AST-1, a class A beta-lactamase from Nocardia asteroides sensu stricto.

PMID 11181374 · 2001

Gene Information

Gene Name: blaAST
Allele: blaAST-1
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: TICARCILLINAMOXICILLINAMPICILLIN+CLAVULANIC ACIDAMPICILLINAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Nocardia asteroides
Sequence Accession: AF279904
Notes: Chromosomal class A beta-lactamase

Molecular Characterization and Antimicrobial Susceptibilities of Nocardia Species Isolated from the Soil; A Comparison with Species Isolated from Humans.

PMID 32549367 · 2020

The study identified various antimicrobial resistance genes in Nocardia species isolated from soil, including beta-lactamase, aminoglycoside modifying enzymes, macrolide resistance genes, chloramphenicol resistance proteins, vancomycin resistance, and multidrug efflux pumps. Some soil N. cyriacigeorgica strains exhibited distinct genetic profiles suggesting possible new subspecies or species.

Gene Information

Gene Name: blaAST
Allele: blaAST-1
Encodes: beta-lactamase
Source Database: Reslit
Confers Resistance To: Amoxicillin/clavulanic acid
Organisms Tested In: • Nocardia cyriacigeorgica
Geographic Location: Venezuela
Validation Method: genomic analysis
Sequence Accession: JAAGVC000000000|JAAGVB000000000|JAAGVA000000000|JAAGUZ000000000|JAAGUY000000000|JAAGUX000000000

Browse AMR Genes

blaAST

Gene Information

Gene Information

Gene Information

Gene Information

Gene Information