blaB

metallo-beta-lactamase

Validation StatusCandidate

Overview

Mechanism: hydrolysis of β-lactam ring
Validation Method: PCR and hybridization assays
Drug Classes: carbapenems, penicillins, cephalosporins
Organisms: Chryseobacterium (Flavobacterium) meningosepticum, Chryseobacterium meningosepticum, Escherichia coli
Geographic Location: United Kingdom|USA|France
Papers: 2
Databases: Reslit

Papers2

Carbapenemases of Chryseobacterium (Flavobacterium) meningosepticum: distribution of blaB and characterization of a novel metallo-beta-lactamase gene, blaB3, in the type strain, NCTC 10016.

PMID 10817691 · 2000

The study characterizes the blaB, blaB2, and blaB3 genes, which encode metallo-beta-lactamases in Chryseobacterium (Flavobacterium) meningosepticum, contributing to carbapenem resistance.

Gene Information

Gene Name: blaB
Allele: blaB
Encodes: metallo-beta-lactamase
Source Database: Reslit
Confers Resistance To: carbapenems
Organisms Tested In: • Chryseobacterium (Flavobacterium) meningosepticum
Geographic Location: United Kingdom|USA|France
Validation Method: PCR and hybridization assays
Sequence Accession: AF126542|AF162284

Overproduction and biochemical characterization of the Chryseobacterium meningosepticum BlaB metallo-beta-lactamase.

PMID 12019109 · 2002

The study characterizes the BlaB metallo-beta-lactamase from Chryseobacterium meningosepticum, demonstrating its ability to hydrolyze various β-lactam antibiotics including penicillins, carbapenems, and cephalosporins.

Gene Information

Gene Name: blaB
Allele: blaB
Encodes: metallo-beta-lactamase
Source Database: Reslit
Mechanism: hydrolysis of β-lactam ring
Confers Resistance To: penicillinscarbapenemscephalosporins
Organisms Tested In: • Chryseobacterium meningosepticum
• Escherichia coli
Validation Method: overproduction and biochemical characterization

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